Redox nanoparticle increases the chemotherapeutic efficiency of pioglitazone and suppresses its toxic side effects

Thangavel, Sindhu; Yoshitomi, Toru; Sakharkar, Meena Kishore; Nagasaki, Yukio

doi:10.1016/j.biomaterials.2016.05.001

Cited by 20 publications

(9 citation statements)

References 36 publications

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“…[9, 25] Nanoparticles have been widely studied for delivery of drugs and vaccines. [36–40] Nanoparticles are able to maintain the activity of payloads and enhance delivery efficiency. In addition, high payload loading capacity, improved bioavailability, and controlled payload release can be achieved by nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

Rationalization of a nanoparticle-based nicotine nanovaccine as an effective next-generation nicotine vaccine: A focus on hapten localization

Zhao

Harmon

et al. 2017

Biomaterials

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A lipid-polymeric hybrid nanoparticle-based next-generation nicotine nanovaccine was rationalized in this study to combat nicotine addiction. A series of nanovaccines, which had nicotine-haptens localized on carrier protein (LPKN), nanoparticle surface (LPNK), or both (LPNKN), were designed to study the impact of hapten localization on their immunological efficacy. All three nanovaccines were efficiently taken up and processed by dendritic cells. LPNKN induced a significantly higher immunogenicity against nicotine and a significantly lower anti-carrier protein antibody level compared to LPKN and LPNK. Meanwhile, it was found that the anti-nicotine antibodies elicited by LPKN and LPNKN bind nicotine stronger than those elicited by LPKN, and LPNK and LPNKN resulted in a more balanced Th1-Th2 immunity than LPKN. Moreover, LPNKN exhibited the best ability to block nicotine from entering the brain of mice. Collectively, the results demonstrated that the immunological efficacy of the hybrid nanoparticle-based nicotine vaccine could be enhanced by modulating hapten localization, providing a promising strategy to combatting nicotine addiction.

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Section: Discussionmentioning

confidence: 99%

Rationalization of a nanoparticle-based nicotine nanovaccine as an effective next-generation nicotine vaccine: A focus on hapten localization

Zhao

Harmon

et al. 2017

Biomaterials

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“…Phototherapy is one of the promising non-invasive clinical approaches to eradicate cancer owing to its high efficiency and minimal side effects, which are achieved by using radiation energy to kill cancer [4]. Phototherapy will convert light energy into either chemical energy or heat energy in the body, resulting in a series of chemical reactions in the body to reach the therapeutic effect [5]. When represented by photodynamic (PDT) [4] or photothermal (PTT) [6] therapies, phototherapy requires light and photoactive agents to generate reactive oxygen species (ROS) or heat, respectively.…”

Section: Introductionmentioning

confidence: 99%

Recent progress in synergistic chemotherapy and phototherapy by targeted drug delivery systems for cancer treatment

Cao

Chen

Chi

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Although it's pharmacological effect for cancer therapy, conventional chemotherapy has been compromised by a series of shortcomings such as limited stability, nonspecific tumour targeting ability and severe toxic side effects. To overcome these limitations, multifunctional targeted drug delivery systems for combinatorial therapeutics have been widely explored as novel cancer therapy strategies, showing encouraging results in many pre-clinical animal experiments. Among them, synergistic phototherapy and chemotherapy have demonstrated their abilities to enhance therapeutic efficacies and reduce unwanted side effects via a variety of mechanisms. In this review, we will summarize the latest progress in the development of targeted drug delivery systems with combinations of phototherapy and chemotherapy and discuss the important roles of phototherapy agents involved in those non-conventional therapeutic strategies.

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“…Currently, the traditional surgery combined with chemoradiotherapy was widely applied during its therapy. However, the radiotherapy and chemotherapy would inevitably damage the normal cells and the patient’s immune systems (Ng and Lee, 2017), which more or less lead to the toxicity and severe effects in some tissues and organs (Thangavel et al, 2016). And the strong invasion ability of NPC cells and its inclination to distal metastasis made its treatments become more difficult (Jiang et al, 2014; Yang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Isolation and Purification of Active Antimicrobial Peptides from Hermetia illucens L., and Its Effects on CNE2 Cells

Tian

Feng

Sun

et al. 2018

Preprint

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Active antimicrobial peptide HI-3 was isolated and purified from the 5th instar larvae of Hermetia illucens L., and its effects on proliferation, apoptosis and migration of nasopharyngeal carcinoma (CNE2) cells were investigated. The expressions of telomerase reverse transcriptase (hTERT) in CNE2 cells were also studied in vitro to elucidate the mechanism involved in the action of HI-3 on CNE2 cells. Results showed that three fractions (HI-1, HI-2, HI-3) were isolated from the hemolymph of H. illucens larvae. After purified by RP-HPLC, only HI-3 showed the inhibitory activities to four strains of bacteria. It was also showed that HI-3 could effectively inhibit the proliferation of CNE2 cells in a dose- and time-dependent manner. Apoptosis of CNE2 cells was observed in the treatment with 160 μg/ml HI-3, and the early apoptosis rate up to 27.59 ± 1.14%. However, no significantly inhibitory effects and apoptosis were found on human umbilical vein endothelial cells (HUV-C). Moreover, HI-3 could significantly reduce the migration ability of CNE2 cells when compared with that of the control. On the other hand, the levels of mRNA and protein of hTERT in the HI-3 treatment were all significantly lower than that of the control. Results indicated that HI-3 could inhibit the proliferation of CNE2 cells and induce the apoptosis of CNE2 cells by down-regulating the telomerase activity in CNE2 cells, while no obvious effect was occurred on HUV-C. It inferred that HI-3 is a potential anti-tumor drug with low toxicity to normal cells.Summary StatementAn active antimicrobial peptide HI-3 was isolated and purified.Inhibitory proliferation of CNE2 cells, but no effect on normal cells.A potential antitumoral drug.

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Redox nanoparticle increases the chemotherapeutic efficiency of pioglitazone and suppresses its toxic side effects

Cited by 20 publications

References 36 publications

Rationalization of a nanoparticle-based nicotine nanovaccine as an effective next-generation nicotine vaccine: A focus on hapten localization

Rationalization of a nanoparticle-based nicotine nanovaccine as an effective next-generation nicotine vaccine: A focus on hapten localization

Recent progress in synergistic chemotherapy and phototherapy by targeted drug delivery systems for cancer treatment

Isolation and Purification of Active Antimicrobial Peptides from Hermetia illucens L., and Its Effects on CNE2 Cells

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