2020
DOI: 10.1038/s41589-019-0462-8
|View full text |Cite
|
Sign up to set email alerts
|

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

4
284
0
1

Year Published

2020
2020
2024
2024

Publication Types

Select...
8
2

Relationship

1
9

Authors

Journals

citations
Cited by 385 publications
(302 citation statements)
references
References 58 publications
4
284
0
1
Order By: Relevance
“…112 Ferroptosis also occurs in macrophages. [113][114][115] However, compared with cancer cells, macrophages exert higher resistance to ferroptosis. Erastin and deleting SLC7A11 expression were not sufficient to induce macrophage ferroptosis unless under high iron conditions.…”
Section: The Interaction Of Ferroptosis and Lipid Metabolism Modulatementioning
confidence: 99%
“…112 Ferroptosis also occurs in macrophages. [113][114][115] However, compared with cancer cells, macrophages exert higher resistance to ferroptosis. Erastin and deleting SLC7A11 expression were not sufficient to induce macrophage ferroptosis unless under high iron conditions.…”
Section: The Interaction Of Ferroptosis and Lipid Metabolism Modulatementioning
confidence: 99%
“…Another study reported that M1 phagocytes exert higher ferroptosis resistance than M2 phagocytes, but that inducible nitric oxide synthase (iNOS)/NO-enrichment of phagocytes can modulate the sensibility of phagocytes to ferroptosis. iNOS depletion/inactivation makes M1 cells sensitive to ferroptosis, while NO donors promote ferroptosis resistance of M2 cells (117). Combining immunotherapy with irradiation can even reverse the chemo-resistance of cancer cells.…”
Section: Clinical Application Of Ferroptosis In Immunotherapymentioning
confidence: 99%
“…Lastly, it is worth mentioning that NO is a potent inhibitor of lipid peroxidation, and therefore, it is expected to inhibit ferroptosis. Indeed, the antiferroptotic action of NO has recently been demonstrated [119].…”
Section: Ferroptosismentioning
confidence: 99%