Redox-Dependent Mechanisms in Coronary Collateral Growth: The “Redox Window” Hypothesis

Yun, June; Ročić, Petra; Pung, Yuh Fen; Belmadani, Souâd; Carrao, Ana Catarina Ribeiro; Ohanyan, Vahagn; Chilian, William M.

doi:10.1089/ars.2009.2476

Cited by 69 publications

(57 citation statements)

References 117 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mild, but not severe, increases in reactive oxygen and nitrogen species are needed to transduce VEGF's angiogenic signal. This concept is now known as the redox window 42 ( Figure 3) and might be one explanation for the angiogenic paradox (increased versus impaired angiogenesis) in different vascular beds in diabetes as well as the reason why 'therapeutic angiogenesis trials' failed. 42,62 Several studies provided evidence as to how the redox window modulates VEGF-A signaling in diabetic retinopathy.…”

Section: Diabetes and Neovascularizationmentioning

confidence: 99%

Cerebral Neovascularization in Diabetes: Implications for Stroke Recovery and beyond

Ergul

Abdelsaid

Fouda

et al. 2014

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Neovascularization is an innate physiologic response by which tissues respond to various stimuli through collateral remodeling (arteriogenesis) and new vessel formation from existing vessels (angiogenesis) or from endothelial progenitor cells (vasculogenesis). Diabetes has a major impact on the neovascularization process but the response varies between different organ systems. While excessive angiogenesis complicates diabetic retinopathy, impaired neovascularization contributes to coronary and peripheral complications of diabetes. How diabetes influences cerebral neovascularization remained unresolved until recently. Diabetes is also a major risk factor for stroke and poor recovery after stroke. In this review, we discuss the impact of diabetes, stroke, and diabetic stroke on cerebral neovascularization, explore potential mechanisms involved in diabetes-mediated neovascularization as well as the effects of the diabetic milieu on poststroke neovascularization and recovery, and finally discuss the clinical implications of these effects.

show abstract

Section: Diabetes and Neovascularizationmentioning

confidence: 99%

Cerebral Neovascularization in Diabetes: Implications for Stroke Recovery and beyond

Ergul

Abdelsaid

Fouda

et al. 2014

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

show abstract

“…Resting distal coronary pressure consistently falls as stenosis severity exceeds 70% (13). Myocardial ischemia, growth factors and shear stress are likely the factors that contributes to initiating and remodeling for collateral development during the tissue hypoxia (15). The severity of CAD and the duration of myocardial ischemic symptoms were described as influencing the development of coronary collaterals (16).…”

Section: Discussionmentioning

confidence: 99%

Increased gamma-glutamyl transferase level is associated with absence of coronary collateral vessels in patients with acute coronary syndrome: an observational study

Duran¹,

Günebakmaz²,

Uysal³

et al. 2012

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

Increased gamma-glutamyl transferase level is associated with absence of coronary collateral vessels in patients with acute coronary syndrome: an observational study Akut koroner sendromlu hastalarda artmış gamma-glutamyl transferase seviyesi koroner kollateral damar yokluğu ile ilişkilidir: Gözlemsel bir çalışma ABSTRACTObjective: Elevated serum gamma-glutamyl transferase (GGT) level has been proposed as a risk factor for coronary artery disease and is associated with poor clinical outcome in acute coronary syndrome (ACS). We aimed to evaluate the relationship between GGT level and presence of coronary collateral vessels (CCV) patients with ACS. Methods: We evaluated 178 patients with ACS in this cross-sectional-observational study. Traditional laboratory and clinical parameters and serum GGT levels were measured. All patients underwent coronary angiography on the first day after admission and patients who had >80% stenosis of coronary artery were included in the study. The CCVs graded according to the Rentrop scoring system and Rentrop 0, 1, 2 and 3 were determined in respectively 76 (42.7%), 32 (18.0%), 33 (18.5%), and 37 (20.8%) patients. Rentrop grade 0 was accepted as no CCV development (Group 1), Rentrop grades 1-2-3 were accepted as presence of CCV development (Group 2). Statistical analysis was performed using independent-samples t , Mann-Whitney U and Chi-squared tests, logistic regression and receiver operator curve analyses. Results: Mean age was 62±10 years and 134 (75.3%) of patients were male. Group 1 consisted of 76 (42.7%) patients and Group 2 consisted of 102 (57.3%) patients. The median and minimum-maximum values of serum GGT were 33.5 (8-128) U/L for Group 1 and 23 (2-83) U/L for Group 2. Absence of CCV was significantly associated with high levels of GGT (p<0.001), alanine-aminotransferase (p=0.001), glucose (p=0.011) and low levels of total protein (p=0.020). At multivariate analysis, high levels of GGT were independent predictors of absence of CCV (OR=0.953, p=0.031). Conclusion: High levels of GGT on admission were associated with absence of CCV in patients with ACS. (Anadolu Kardiyol Derg 2012; 12: 652-8) Key words: Gamma-glutamyl transferase, coronary collateral vessel, acute coronary syndrome, regression analysis, sensitivity, specificity Original Investigation Özgün Araşt›rma 652ÖZET Amaç: Yüksek serum gamma-glutamyl transferase (GGT) düzeyi koroner arter hastalığı için risk faktörü olarak tanımlanmıştır ve akut koroner sendromlu (AKS) hastalarda kötü klinik sonuçlarla ilişkilidir. Bu çalışmada AKS olan hastalarda serum GGT düzeyi ile koroner kollateral damar (KKD) varlığı arasındaki ilişki incelendi. Yöntemler: Kesitsel ve gözlemsel çalışmamıza 178 AKS'li alındı. Rutin laboratuvar, GGT düzeyleri ve klinik parametreleri ölçüldü. Hastalar ilk 24 saat içinde anjiyografiye alındı ve >%80 lezyonu olanlar çalışmaya dahil edildi. KKD sınıflaması Rentrop skoruna göre yapıldı. Rentrop 0: 76 (%42.7), 1: 32 (%18.0), 2: 33 (%18.5), ve 3: 37 (%20.8) hastada tespit edildi. Rentrop 0 kollateral da...

show abstract

“…On the opposite side of the spectrum, too little ROS and the consequential reductive stress, also inhibits coronary collateral growth. This optimal "level" of ROS has been dubbed "redox window" [24], which is the level of the redox state that is optimal for growth factor signaling. p53 is thought to be the connection between redox dependent and growth factor dependent signaling.…”

Section: The "Good Side" Of Rosmentioning

confidence: 99%

“…As a result, this particular species is exclusively deleterious when produced within a cell. When the ROS levels deviate away from the "redox widow," imbalance in these systems occurs and detrimental consequences can be triggered [24].…”

Section: The "Good Side" Of Rosmentioning

confidence: 99%

Reactive Oxygen Species: The Good and the Bad

Patel¹,

Rinker²,

Peng³

et al. 2018

Reactive Oxygen Species (ROS) in Living Cells

Self Cite

View full text Add to dashboard Cite

This chapter summarizes recent research on the biology of reactive oxygen species (ROS). The chapter is focused on the bimodal actions of ROS, which can be summarized as both beneficial and negative. The beneficial aspects of ROS are related to their effects on the redox state of cells and the important role that some ROS play in signaling cascade. The detrimental effects of ROS are related excess amounts of these chemical moieties, which are caused by excessive production and/or insufficient actions of endogenous antioxidants. The generation of these species is also discussed.

show abstract

Redox-Dependent Mechanisms in Coronary Collateral Growth: The “Redox Window” Hypothesis

Cited by 69 publications

References 117 publications

Cerebral Neovascularization in Diabetes: Implications for Stroke Recovery and beyond

Cerebral Neovascularization in Diabetes: Implications for Stroke Recovery and beyond

Increased gamma-glutamyl transferase level is associated with absence of coronary collateral vessels in patients with acute coronary syndrome: an observational study

Reactive Oxygen Species: The Good and the Bad

Contact Info

Product

Resources

About