Redox-active alkyl xanthate esters enable practical C–S cross-coupling by nickel catalysis

Abstract

Sulfur-containing compounds are increasingly important for designing pharmaceutical candidates that have accumulated broad research efforts toward developing effective methods to forge C-S bonds from various sulfuration agents. However, most established...

Direct and modular access to allylic amines via nickel-catalyzed three-component coupling

“…Over the past decades, transition metal-catalyzed MCRs have been widely explored to construct valuable functionalized molecules, largely extending the chemical sphere of MCRs. 41,42 Within our continuing interest in the synthesis of important scaffolds via nickel catalysis, 43–46 we herein disclose a Ni(0)-catalyzed three-component reaction of commercially available aldehydes, amines, and alkenes (Fig. 1b).…”

EtOS2K as a C1 Source: Solvent- and Temperature-Controlled Selective Synthesis of Quinoline-2-thione and Quinoline-2-one Derivatives

“…Potassium ethyl xanthate (EtOS 2 K) is an crucial and desirable sulfur-containing reagent and has been widely used in academia and industry, and its popularity stems from its low toxicity, easy handling, bench stability, odorless nature, and commercial availability . Recently, Zard and his colleagues reported a versatile strategy to generate radicals from EtOS 2 K, and it have been well-studied as a inexpensive and nucleophilic organic catalyst .…”