Direct and modular access to allylic amines via nickel-catalyzed three-component coupling
Changyu Xu,
Jianchao Chang,
Zhan Dong
et al.
Abstract:We herein report direct and modular access to allylic amines via Ni(0)-catalyzed three-component coupling of commercially available and inexpensive aldehydes, amines, and alkenes, without the additional steps for isolation of unstable imines.
Recent years have witnessed the emergence of direct intermolecular C(sp3)–H bond functionalization using in situ generated aryl/alkyl radicals as a unique class of hydrogen atom transfer (HAT) agents.
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