Redistribution of organ blood flow after hemorrhage and resuscitation in full-term piglets

Resveratrol Rescues Kidney Mitochondrial Function Following Hemorrhagic Shock

“…Although it accounts for only 2% of total body weight, the kidney receives approximately 25% of the cardiac output (2). With acute blood loss, however, cardiac output drops dramatically and the kidney is subjected to profound vasoconstriction in an attempt to preserve blood flow to more vital organs such as the heart and brain (25). As such, hemorrhagic shock significantly decreases renal perfusion.…”

Effects of Dextran and Pentoxifylline on Hemorrhagic Shock-Induced P-Selectin Expression

“…creas, stomach, intestines) has shown that resuscitation of hemorrhagic shock with a pure solution of dextran 40 restores blood flow to these organs better than Ringer's lactate [30].…”

“…While no-reflow phenomenon and MODS persist despite crystalloid fluid resuscitation, resuscitation with solutions containing dextran have been shown to prevent leukocyte-endothelium adherence and, thus, no-reflow phenomenon and MODS [13,14,19,30]. Additionally, pentoxifylline infusion during resuscitation has also been shown to exert similar effects [31][32][33][34][35][36][37].…”

Near‐infrared spectroscopy: exposing the dark (venous) side of the circulation

“…Increased systemic vascular resistance maintains perfusion of heart and brain, at the expense of perfusion to the kidneys and mesenteric organs, with subsequent development of organ dysfunction and increased mortality . Two‐site NIRS is valuable in the identification of somatic hypoperfusion in early compensated shock, as reduced renal/mesenteric perfusion may be clinically silent until organ dysfunction occurs .…”