Effects of Dextran and Pentoxifylline on Hemorrhagic Shock-Induced P-Selectin Expression

Role of Hypertonic Saline and Pentoxifylline on Neutrophil Activation and Tumor Necrosis Factor-α Synthesis: A Novel Resuscitation Strategy

“…Firm adhesion associated with potent chemotactic stimuli will eventually lead to migration of inflammatory cells to the interstitial space where degranulation occurs. 14,40,46,47,57 In the current study, we demonstrate that PTX treatment reduces neutrophil CD11b expression in LPS-stimulated whole blood. Furthermore, the addition of HS40 to PTX creates a synergistic effect on CD11b expression compared with PTX or HS40 alone.…”

“…In addition, PTX decreases neutrophil oxidative burst and adherence to endothelial cells, likely by a mechanism involving the regulation of adhesion molecule expression. [43][44][45][46][47] The mechanism by which neutrophils produce oxygen reactive species is stimulus-dependent. The cellular activation after LPS stimulation occurs when LPS is presented to a surface glycoprotein, CD14, after binding to the LPS-binding protein.…”

Effects of colloid solutions on ischemia-reperfusion-induced periosteal microcirculatory and inflammatory reactions: Comparison of dextran, gelatin, and hydroxyethyl starch*

“…By this approach, perfusion reactions and possible anti-inflammatory consequences could be examined unambiguously, without contributions from other, potentially modifying factors. Crystalloid solutions could induce inflammatory activation by affecting cell-cell interactions (16) and cause a hypercoagulable state, probably due to hyperchloremia (23).…”

Targeted renal therapies through microbubbles and ultrasound☆

“…Until now, targeted microbubbles in renal disease have been primarily aimed at P-selectin in experimental models of renal inflammation after ischemia-reperfusion injury. Furthermore, renal upregulation of P-selectin expression has been described for several other kidney diseases including renal allograft dysfunction [90-92], glomerulonephritis[93-95], renal shock[96,97] and diabetic nephropathy [98,99], indicating that microbubbles targeted to P-selectin may be applied in these kidney diseases. However, the selective targeting of microbubbles to leukocyte anchoring molecules in kidney disease may be compromised when the kidney disease is accompanied by a state of systemic inflammation such as sepsis, reperfusion injury, atheriosclerosis and metabolic dysfunction.…”