Redefining the functional roles of the gastrointestinal migrating motor complex and motilin in small bacterial overgrowth and hunger signaling

Deloose, Eveline; Tack, Jan

doi:10.1152/ajpgi.00212.2015

Cited by 23 publications

(10 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During fasting, the gastrointestinal tract exerts a cyclic activity, alternating between periods of quiescence and periods of intense motor and secretory activity. The function of this stereotyped pattern, known as the migrating motor complex (MMC), appears to be the propulsion of residues from the lumen of the small intestine into the colon; thus, it is considered to be the intestinal housekeeper [2].…”

Section: Physiological Responses To Meal Ingestionmentioning

confidence: 99%

Food, Eating, and the Gastrointestinal Tract

2020

View full text Add to dashboard Cite

Food ingestion induces a metered response of the digestive system. Initially, the upper digestive system reacts to process and extract meal substrates. Later, meal residues not absorbed in the small bowel, pass into the colon and activate the metabolism of resident microbiota. Food consumption also induces sensations that arise before ingestion (e.g., anticipatory reward), during ingestion (e.g., gustation), and most importantly, after the meal (i.e., the postprandial experience). The postprandial experience involves homeostatic sensations (satiety, fullness) with a hedonic dimension (digestive well-being, mood). The factors that determine the postprandial experience are poorly understood, despite their potential role in personalized diets and healthy eating habits. Current data suggest that the characteristics of the meal (amount, palatability, composition), the activity of the digestive system (suited processing), and the receptivity of the eater (influenced by multiple conditioning factors) may be important in this context.

show abstract

Section: Physiological Responses To Meal Ingestionmentioning

confidence: 99%

Food, Eating, and the Gastrointestinal Tract

2020

View full text Add to dashboard Cite

show abstract

“…It is well-established that nutrient intake activates a neurohumoral feedback mechanism with extensive effects on gastrointestinal motility to limit the delivery of nutrients to the duodenum (5). Phasic contractile waves associated with the interdigestive fasted state cease (1,22) while the proximal stomach (fundus and proximal part of the corpus) relaxes to facilitate the intake of a substantial meal volume, without an increase in intragastric pressure, known as gastric accommodation (23,24).…”

Section: Discussionmentioning

confidence: 99%

“…This cyclic pattern has three distinctive phases and repeats itself every 90-150 min. The physiological function of the MMC is incompletely elucidated (1).…”

Section: Introductionmentioning

confidence: 99%

Repeated Gastric Motility Measurement Affects Gastric Motility and Epigastric Symptom Sensation

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: Gastric motility is an important determinant of gastric emptying, epigastric symptom generation, and intolerance to food. Motility is classically assessed directly using manometry or an intragastric balloon. These diagnostic methods are perceived as stressful and invasive, which, by itself might influence the readout of these assessments. Our hypothesis was that with repeated exposure to an invasive motility test the outcome would be different. Methods: Gastric motility was assessed with a custom-made orogastric balloon catheter in 10 healthy subjects naive to intubation. A motility index ranging from 0 (no motility) to 1 (maximum motility) was calculated in the fasted state for 3.5 h. Symptoms were surveyed with visual analog scales of 100 mm. Results are presented as median (interquartile range). Results: Motility index during visit 1 [0.40 (0.37-0.59)] was lower compared to visit 2 [0.50 (0.45-0.66); not significant] and 3 [0.63 (0.50-0.71); p = 0.016]. Nausea and pain scores were significantly higher during visit 1 (35 (2.8-126) and 103 (88-125) mm, respectively) compared with visit 3 [1 (2.8-26) mm (p = 0.016) and 75 (30-100) mm (p = 0.008), respectively]. No adverse events were observed. Conclusions: Repeated exposure to an invasive method to assess motility resulted in more vigorous motility and lower symptom scores. Caution is warranted when interpreting functional assessments, as prior exposure to invasive tests might confound the obtained results through habituation.

show abstract

“…One motor event, the migrating motor complex (MMC), a cyclic motor pattern that occurs during the interdigestive state, plays an important role in preventing the development of bacterial overgrowth within the small intestine (83). In fact, the MMC is commonly referred to as the “intestinal housekeeper,” emphasising its role in gastrointestinal health (84). Under physiological conditions, the MMC sustains the aboral progression of luminal content in the small intestine between meals, thereby preventing stasis and SIBO.…”

Section: Risk Factors For Sibomentioning

confidence: 99%

Small Intestinal Bacterial Overgrowth in Children: A State-Of-The-Art Review

et al. 2019

View full text Add to dashboard Cite

Small intestinal bacterial overgrowth (SIBO) is a heterogenous and poorly understood entity characterised by an excessive growth of select microorganisms within the small intestine. This excessive bacterial biomass, in turn, disrupts host physiology in a myriad of ways, leading to gastrointestinal and non-gastrointestinal symptoms and complications. SIBO is a common cause of non-specific gastrointestinal symptoms in children, such as chronic abdominal pain, abdominal distention, diarrhoea, and flatulence, amongst others. In addition, it has recently been implicated in the pathophysiology of stunting, a disease that affects millions of children worldwide. Risk factors such as acid-suppressive therapies, alterations in gastrointestinal motility and anatomy, as well as impoverished conditions, have been shown to predispose children to SIBO. SIBO can be diagnosed via culture-dependant or culture-independent approaches. SIBO's epidemiology is limited due to the lack of uniformity and consensus of its diagnostic criteria, as well as the paucity of literature available. Antibiotics remain the first-line treatment option for SIBO, although emerging modalities such as probiotics and diet manipulation could also have a role. Herein, we present a state-of-the-art-review which aims to comprehensively outline the most current information on SIBO in children, with particular emphasis on the gut microbiota.

show abstract

Redefining the functional roles of the gastrointestinal migrating motor complex and motilin in small bacterial overgrowth and hunger signaling

Abstract: Deloose E, Tack J. Redefining the functional roles of the gastrointestinal migrating motor complex and motilin in small bacterial overgrowth and hunger signaling.

Cited by 23 publications

References 57 publications

Food, Eating, and the Gastrointestinal Tract

Food, Eating, and the Gastrointestinal Tract

Repeated Gastric Motility Measurement Affects Gastric Motility and Epigastric Symptom Sensation

Small Intestinal Bacterial Overgrowth in Children: A State-Of-The-Art Review

Contact Info

Product

Resources

About