Red Seaweed Pigments from a Biotechnological Perspective

Freitas, Mário; Pacheco, Diana; Cotas, João; Mouga, Teresa; Afonso, Clélia; Pereira, Leonel

doi:10.3390/phycology2010001

Cited by 42 publications

(45 citation statements)

References 240 publications

(357 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, J. rubens was collected at 2–3 m deep, and this could explain the high amount of chlorophyll. The role of seaweed pigments is not only to characterize each group of algae but also it has an important role as an antioxidant, anti-inflammatory, and anticancer [ 47 , 48 , 49 , 50 ]. Previous studies showed that chlorophyll and carotenoids inhibit cancer proliferation and can induce apoptosis in different cell lines, including colon cancer cells (HT-29, Caco-2), breast cancer cells (MCF-7), T-cell leukemia, and others [ 51 , 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

The Lebanese Red Algae Jania rubens: Promising Biomolecules against Colon Cancer Cells

et al. 2022

View full text Add to dashboard Cite

Colorectal cancer (CRC) is ranked the second most lethal type of tumor globally. Thus, developing novel anti-cancer therapeutics that are less aggressive and more potent is needed. Recently, natural bioactive molecules are gaining interest as complementary and supportive antineoplastic treatments due to their safety, effectiveness, and low cost. Jania rubens (J. rubens) is a red coral seaweed abundant in the Mediterranean and bears a significant pharmacological essence. Despite its therapeutic potential, the natural biomolecules extracted from this alga are poorly identified. In this study, the proximal analysis revealed high levels of total ash content (66%), 11.3% proteins, 14.5% carbohydrates, and only 4.5% lipids. The elemental identification showed magnesium and calcium were high among its macro minerals, (24 ± 0.5 mg/g) and (33 ± 0.5 mg/g), respectively. The Chlorophyll of J. rubens was dominated by other pigments with (0.82 ± 0.02 mg/g). A 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay identified effective antioxidant activity in various J. rubens extracts. More importantly, a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) tetrazolium reduction and wound healing assays indicate that organic extracts from J. rubens significantly counteract the proliferation of colon cancer cell lines (HCT-116 and HT-29) and inhibit their migratory and metastatic properties in a dose and time-dependent manner. Overall, this study provides insight into the physicochemical properties of red seaweed, J. rubens, and identifies its significant antioxidant, cytotoxic, and anti-migratory potential on two colorectal cell lines, HCT-116 and HT-29.

show abstract

Section: Discussionmentioning

confidence: 99%

The Lebanese Red Algae Jania rubens: Promising Biomolecules against Colon Cancer Cells

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Such production is governed by their species and metabolism. In different species, the R-PE content might range from 0.14 mg g −1 to 54.3 mg g −1 [ 34 , 35 ]. Palmaria palmata has the highest content among the studies [ 34 ].…”

Section: C-pe Producer Speciesmentioning

confidence: 99%

A Review on a Hidden Gem: Phycoerythrin from Blue-Green Algae

et al. 2022

View full text Add to dashboard Cite

Phycoerythrin (PE) is a pink/red-colored pigment found in rhodophytes, cryptophytes, and blue-green algae (cyanobacteria). The interest in PE is emerging from its role in delivering health benefits. Unfortunately, the current cyanobacterial-PE (C-PE) knowledge is still in the infant stage. It is essential to acquire a more comprehensive understanding of C-PE. This study aimed to review the C-PE structure, up and downstream processes of C-PE, application of C-PE, and strategies to enhance its stability and market value. In addition, this study also presented a strengths, weaknesses, opportunities, and threats (SWOT) analysis on C-PE. Cyanobacteria appeared to be the more promising PE producers compared to rhodophytes, cryptophytes, and macroalgae. Green/blue light is preferred to accumulate higher PE content in cyanobacteria. Currently, the prominent C-PE extraction method is repeated freezing–thawing. A combination of precipitation and chromatography approaches is proposed to obtain greater purity of C-PE. C-PE has been widely exploited in various fields, such as nutraceuticals, pharmaceuticals, therapeutics, cosmetics, biotechnology, food, and feed, owing to its bioactivities and fluorescent properties. This review provides insight into the state-of-art nature of C-PE and advances a step further in commercializing this prospective pigment.

show abstract

“…(µg/kg fresh weight) (µg/mL of extract) phycoerythrin (R-PE) (red color), Rhodophyta phycocyanin (R-PC) (blue color) and allophycocyanin (APC), (2) carotenoids, (3) xanthophylls and (4) chlorophyll a (Chl a) (Freitas et al, 2021). These compounds have an important role in seaweed growth and development by harvesting solar energy and transforming it into chemical energy.…”

Section: Parameter *mentioning

confidence: 99%

“…Extraction optimization of pigments such as R-PE (Uju et al, 2020), b-carotene and chlorophyll (Baskararaj et al, 2019) and carrageenan (Mahyati and Azis, 2019) from K. alvarezii has been reported. (Freitas et al, 2021) provided an interesting review of the chemical diversity of the different pigments produced by red seaweeds and their biotechnological applications along with the number of patents registered.…”

Section: Kappaphycus Sppmentioning

confidence: 99%

Valorization of the chemical diversity of the tropical red seaweeds Acanthophora and Kappaphycus and their applications in aquaculture: A review

Guillen

Motti²,

Mangelinckx³

et al. 2022

Front. Mar. Sci.

View full text Add to dashboard Cite

The role that seaweeds play as primary producers and ecosystems engineers in marine coastal ecosystems is widely acknowledged. Seaweeds, however, are also important drivers in the development of the blue bioeconomy due to their vast diversity of unique chemicals with a broad range of industrial and biotechnological applications. In tropical regions, seaweed production has been focused on a few species only, because of their hydrocolloids used in the food industry. There is a strong need to identify new applications of red seaweed species in other sectors such as aquaculture. Therefore, to diversify the culture of red seaweeds, more tropical species need to be investigated for their chemical composition and potential application in aquaculture, and then, to develop a method for a sustainable cultivation of new seaweed candidates and enhance their economic potential. Based on this context, we analyze the potential value of the red edible seaweed Acanthophora spp., an under-valued seaweed species which is naturally abundant in tropical countries, and Kappaphycus spp., a commercially valuable seaweed commonly used for polysaccharide extraction. The vast chemical diversity of seaweeds (polysaccharides, phytohormones, amino acids, and pigments) has led to research on a wide range of applications in aquaculture, including pathogen control, immunostimulant, antioxidant, bioremediation, feed, UV protectants, increase in seafood shelf life, animal colorant, and growth regulator for microalga culture. This review hopes to stimulate the interest among seaweed researchers to investigate other local seaweed species and seek greater added value of their biomass and chemical compounds and their applications in the aquaculture sector. Additionally, this information will help stakeholders to benefit from these two red seaweeds by contributing to the diversification of the blue bioeconomy in tropical countries.

show abstract

Red Seaweed Pigments from a Biotechnological Perspective

Cited by 42 publications

References 240 publications

The Lebanese Red Algae Jania rubens: Promising Biomolecules against Colon Cancer Cells

The Lebanese Red Algae Jania rubens: Promising Biomolecules against Colon Cancer Cells

A Review on a Hidden Gem: Phycoerythrin from Blue-Green Algae

Valorization of the chemical diversity of the tropical red seaweeds Acanthophora and Kappaphycus and their applications in aquaculture: A review

Contact Info

Product

Resources

About