The Lebanese Red Algae Jania rubens: Promising Biomolecules against Colon Cancer Cells

Rifi, Mariam; Radwan, Zeina; AlMonla, Reem; Fajloun, Ziad; Sabatier, Jean‐Marc; Kouzayha, Achraf; El-Sabban, Marwan; Mawlawi, Hiba; Dassouki, Zeina

doi:10.3390/molecules27196617

Cited by 3 publications

(1 citation statement)

References 78 publications

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“…Coralline seaweeds have shown potential as a dietary calcium supplement to promote bone health [60][61][62]. Other authors have unveiled the antimicrobial potential of dichloromethane extracts of C. officinalis against E. coli [96], the antioxidant [97,98], anti-inflammatory and anticancer potential of methanolic extracts of J. rubens and E. elongata (formerly C. elongata) [98], and the insecticidal [99], anti-tumour [100] and anti-bacterial [101] potential of the methanolic, organic and ethanolic extracts, respectively, of J. rubens.…”

Section: Species-specific Notesmentioning

confidence: 99%

Antioxidant and Antimicrobial Properties of Selected Red Seaweeds from Central Portugal

et al. 2022

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Throughout the ages, macroalgae have provided humankind with elements beneficial to human health, and often with bioactive abilities. Yet, while today we fully acknowledge such potential, especially that of the most widely known species, an even greater number of species remain unaknowledged. This holds particularly true for the highly diverse phylum Rhodophyta (red seaweeds) and, therefore, the present study aims to unveil the antioxidant and the antimicrobial potential of twelve red seaweed species collected in central Portugal. Results obtained from the antioxidant assays ABTS and TPC highlighted the high scavenging capacity of the coralline algae Corallina officinalis, Ellisolandia elongata and Amphiroa rigida, and the high phenolic content of Porphyra umbilicalis, whereas the antimicrobial analyses through MIC determination emphasized the activities of Sphaerococcus coronopifolius and Mesophyllum lichenoides against, respectively, Bacillus subtilis and Saccharomyces cerevisiae. This study raised awareness of the bioactive potential waiting to be discovered regarding less known Rhodophyta species, such as Amphiroa rigida and Mesophyllum lichenoides. Therefore, we believe this study provides extra steps in pinpointing Rhodophyta species with bioactive potential, encouraging further studies tailored toward a biotechnological perspective, and, ultimately, influencing current perspectives regarding the exploration of seaweeds.

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Section: Species-specific Notesmentioning

confidence: 99%

Antioxidant and Antimicrobial Properties of Selected Red Seaweeds from Central Portugal

et al. 2022

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Effect of Apis mellifera syriaca Bee Venom on Glioblastoma Cancer: In Vitro and In Vivo Studies

Chahla,

Rima,

Mouawad

et al. 2024

Molecules

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Glioblastoma multiforme (GBM) is a highly aggressive and fatal primary brain tumor. The resistance of GBM to conventional treatments is attributed to factors such as the blood–brain barrier, tumor heterogeneity, and treatment-resistant stem cells. Current therapeutic efforts show limited survival benefits, emphasizing the urgent need for novel treatments. In this context, natural anti-cancer extracts and especially animal venoms have garnered attention for their potential therapeutic benefits. Bee venom in general and that of the Middle Eastern bee, Apis mellifera syriaca in particular, has been shown to have cytotoxic effects on various cancer cell types, but not glioblastoma. Therefore, this study aimed to explore the potential of A. mellifera syriaca venom as a selective anti-cancer agent for glioblastoma through in vitro and in vivo studies. Our results revealed a strong cytotoxic effect of A. mellifera syriaca venom on U87 glioblastoma cells, with an IC50 of 14.32 µg/mL using the MTT test and an IC50 of 7.49 µg/mL using the LDH test. Cells treated with the bee venom became permeable to propidium iodide without showing any signs of early apoptosis, suggesting compromised membrane integrity but not early apoptosis. In these cells, poly (ADP-ribose) polymerase (PARP) underwent proteolytic cleavage similar to that seen in necrosis. Subsequent in vivo investigations demonstrated a significant reduction in the number of U87 cells in mice following bee venom injection, accompanied by a significant increase in cells expressing caspase-3, suggesting the occurrence of cellular apoptosis. These findings highlight the potential of A. mellifera syriaca venom as a therapeutically useful tool in the search for new drug candidates against glioblastoma and give insights into the molecular mechanism through which the venom acts on cancer cells.

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Development of Bioactive Peptides Derived from Red Algae for Dermal Care Applications: Recent Advances

et al. 2023

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Bioactive peptides produced from proteinaceous red algae biomass with varied structures have garnered much attention in biological applications and production. Unfortunately, there have been few studies on developing approaches to feasible bioactive peptide production and purification. Our goal with this article is to explore the latest trends in easily applicable approaches for extracting bioactive peptides for cutaneous applications. Bibliometric statistics show that the number of scientific publications is growing, with Asia ranking as the highest producer. Peptide purity and bioactivity are the most important factors to consider while extracting and identifying peptides using various separation techniques. To generate novel bioactive peptides with high yield and low cost, future research should focus on increasing the yields and improving the separation methods. Moreover, human clinical trials should be conducted to validate their potential health benefits. Thus, the final objective of this literature review was to give an insight into the bioactive properties of red algae-derived peptides, which have proven potential for dermal application with anti-melanogenic, collagenogenic, antioxidant, antiaging, and photoprotective activities, etc. Moreover, it covers the algal peptides’ scope for use in nutraceuticals and pharmaceuticals, and future studies for their emerging applications.

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The Lebanese Red Algae Jania rubens: Promising Biomolecules against Colon Cancer Cells

Cited by 3 publications

References 78 publications

Antioxidant and Antimicrobial Properties of Selected Red Seaweeds from Central Portugal

Antioxidant and Antimicrobial Properties of Selected Red Seaweeds from Central Portugal

Effect of Apis mellifera syriaca Bee Venom on Glioblastoma Cancer: In Vitro and In Vivo Studies

Development of Bioactive Peptides Derived from Red Algae for Dermal Care Applications: Recent Advances

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