Red paprika (Capsicum annuum L.) and its main carotenoids, capsanthin and β-carotene, prevent hydrogen peroxide-induced inhibition of gap-junction intercellular communication

Kim, Jisun; Lee, Woo-Moon; Rhee, Han Cheol; Kim, Suna

doi:10.1016/j.cbi.2016.05.004

Cited by 35 publications

(14 citation statements)

References 37 publications

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“…However, the authors also detected other carotenoids specific for paprika, such as cryptocapsin, capsanthin, capsorubin (just found in paprika and lily pollen), cucurbitaxanthin A (found just in paprika and pumpkins), and finally capsanthone (a possible oxidative product of capsanthin). Paprika carotenoids, particularly capsanthin and capsorubin, have been reported to have a strong antioxidant activity [43, 44]. Based on these results, cucurbitaxanthin A, capsanthin, capsanthone, and cryptocapsin could be potential paprika-specific carotenoid biomarkers.…”

Section: Resultsmentioning

confidence: 97%

Herbs and Spices- Biomarkers of Intake Based on Human Intervention Studies – A Systematic Review

et al. 2019

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Culinary herbs and spices have been used as both food flavoring and food preservative agents for centuries. Moreover, due to their known and presumptive health benefits, herbs and spices have also been used in medical practices since ancient times. Some of the health effects attributed to herbs and spices include antioxidant, anti-microbial, and anti-inflammatory effects as well as potential protection against cardiovascular disease, neurodegeneration, type 2 diabetes, and cancer. While interest in herbs and spices as medicinal agents remains high and their use in foods continues to grow, there have been remarkably few studies that have attempted to track the dietary intake of herbs and spices and even fewer that have tried to find potential biomarkers of food intake (BFIs). The aim of the present review is to systematically survey the global literature on herbs and spices in an effort to identify and evaluate specific intake biomarkers for a representative set of common herbs and spices in humans. A total of 25 herbs and spices were initially chosen, including anise, basil, black pepper, caraway, chili pepper, cinnamon, clove, cumin, curcumin, dill, fennel, fenugreek, ginger, lemongrass, marjoram, nutmeg, oregano, parsley, peppermint and spearmint, rosemary, saffron, sage, tarragon, and thyme. However, only 17 of these herbs and spices had published, peer-reviewed studies describing potential biomarkers of intake. In many studies, the herb or spice of interest was administrated in the form of a capsule or extract and very few studies were performed with actual foods. A systematic assessment of the candidate biomarkers was also performed. Given the limitations in the experimental designs for many of the published studies, further work is needed to better evaluate the identified set of BFIs. Although the daily intake of herbs and spices is very low compared to most other foods, this important set of food seasoning agents should not be underestimated, especially given their potential benefits to human health. Electronic supplementary material The online version of this article (10.1186/s12263-019-0636-8) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 97%

Herbs and Spices- Biomarkers of Intake Based on Human Intervention Studies – A Systematic Review

et al. 2019

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“…Antioxidants such as vitamins (vitamin C and E) [ 63 , 64 ], β carotene [ 65 , 66 ], coenzyme Q10 (CoQ10), melatonin, glutathione, lipoic acid, resveratrol [ 67 ] have shown to scavenge exogenous ROS in various experimental settings (cells and exposure conditions), implicating decrease in oxidative stress which is prodromal to risk and progression of several chronic diseases caused independently or due to CS. Besides acting as direct scavengers of ROS, both vitamin C and E have also been reported to reduce lipid peroxidation [ 68 , 69 ], lymphocyte production, cytokine release, cellular adhesion molecule expression in monocytes [ 64 , 70 ] and histamine release [ 71 ] due to CS exposure thereby acting as an anti-inflammatory agent.…”

Section: Discussionmentioning

confidence: 99%

Unhealthy smokers: scopes for prophylactic intervention and clinical treatment

2017

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BackgroundGlobally, tobacco use causes approximately 6 million deaths per year, and predictions report that with current trends; more than 8 million deaths are expected annually by 2030. Cigarette smokings is currently accountable for more than 480,000 deaths each year in United States (US) and is the leading cause of preventable death in the US. On average, smokers die 10 years earlier than nonsmokers and if smoking continues at its current proportion among adolescents, one in every 13 Americans aged 17 years or younger is expected to die prematurely from a smoking-related illness. Even though there has been a marginal smoking decline of around 5% in recent years (2005 vs 2015), smokers still account for 15% of the US adult population. What is also concerning is that 41,000 out of 480,000 deaths results from secondhand smoke (SHS) exposure. Herein, we provide a detailed review of health complications and major pathological mechanisms including mutation, inflammation, oxidative stress, and hemodynamic and plasma protein changes associated with chronic smoking. Further, we discuss prophylactic interventions and associated benefits and provide a rationale for the scope of clinical treatment.ConclusionsConsidering these premises, it is evident that much detailed translational and clinical studies are needed. Factors such as the length of smoking cessation for ex-smokers, the level of smoke exposure in case of SHS, pre-established health conditions, genetics (and epigenetics modification caused by chronic smoking) are few of the criteria that need to be evaluated to begin assessing the prophylactic and/or therapeutic impact of treatments aimed at chronic and former smokers (especially early stage ex-smokers) including those frequently subjected to second hand tobacco smoke exposure. Herein, we provide a detailed review of health complications and major pathological mechanisms including mutation, inflammation, oxidative stress, and hemodynamic and plasma protein changes associated with chronic smoking. Further, we discuss about prophylactic interventions and associated benefits and provide a rationale and scope for clinical treatment.

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“…Carotenoids are not only exerted antioxidant properties, they are also facilitated in the modulation of cell cycle, apoptosis, and cell differentiation (Gloria et al, 2014 ), enhancement of immune system (Karadas et al, 2016 ), regulate of cell signaling pathways (Kim et al, 2016 ), promote growth factors (Diener and Rohrmann, 2016 ), and adhesion molecules (Llorente et al, 2017 ). Carotenoids are highly lipophilic molecules that reside intracellularly to shield the membrane from oxidative stress (Fiedor and Burda, 2014 ).…”

Section: Role Of Antioxidants In the Prevention Of Age-related Diseasmentioning

confidence: 99%

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

et al. 2018

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Aging is the progressive loss of organ and tissue function over time. Growing older is positively linked to cognitive and biological degeneration such as physical frailty, psychological impairment, and cognitive decline. Oxidative stress is considered as an imbalance between pro- and antioxidant species, which results in molecular and cellular damage. Oxidative stress plays a crucial role in the development of age-related diseases. Emerging research evidence has suggested that antioxidant can control the autoxidation by interrupting the propagation of free radicals or by inhibiting the formation of free radicals and subsequently reduce oxidative stress, improve immune function, and increase healthy longevity. Indeed, oxidation damage is highly dependent on the inherited or acquired defects in enzymes involved in the redox-mediated signaling pathways. Therefore, the role of molecules with antioxidant activity that promote healthy aging and counteract oxidative stress is worth to discuss further. Of particular interest in this article, we highlighted the molecular mechanisms of antioxidants involved in the prevention of age-related diseases. Taken together, a better understanding of the role of antioxidants involved in redox modulation of inflammation would provide a useful approach for potential interventions, and subsequently promoting healthy longevity.

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Red paprika (Capsicum annuum L.) and its main carotenoids, capsanthin and β-carotene, prevent hydrogen peroxide-induced inhibition of gap-junction intercellular communication

Cited by 35 publications

References 37 publications

Herbs and Spices- Biomarkers of Intake Based on Human Intervention Studies – A Systematic Review

Herbs and Spices- Biomarkers of Intake Based on Human Intervention Studies – A Systematic Review

Unhealthy smokers: scopes for prophylactic intervention and clinical treatment

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

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