Red/Near‐Infrared Emissive Metalloporphyrin‐Based Nanodots for Magnetic Resonance Imaging‐Guided Photodynamic Therapy In Vivo

Wu, Fengshou; Chen, Jingwen; Li, Zhicong; Su, Huifang; Leung, Ken Cham‐Fai; Wang, Han; Zhu, Xia

doi:10.1002/ppsc.201800208

Cited by 56 publications

(35 citation statements)

References 43 publications

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“… 163 The Mn-doped CPDs assembly also could effectively generate 1 O 2 (QY of 0.40) and catalyze H 2 O 2 to produce oxygen under hypoxia environments further for simultaneous bimodal fluorescence/MR imaging and enhanced PDT ( Figure 7 b). 164 In addition, molecular dyes (e.g., porphyrin, 165 diketopyrrolopyrrole 166 ), Ru, 66 or Mn-functionalized 167 CDs were used for improving the PDT efficacy (e.g., QY, 1 O 2 yield) and/or multimodal imaging-guided PDT in vivo .…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications

2020

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Carbon dots (CDs), as a new type of carbon-based nanomaterial, have attracted broad research interest for years, because of their diverse physicochemical properties and favorable attributes like good biocompatibility, unique optical properties, low cost, ecofriendliness, abundant functional groups (e.g., amino, hydroxyl, carboxyl), high stability, and electron mobility. In this Outlook, we comprehensively summarize the classification of CDs based on the analysis of their formation mechanism, micro-/nanostructure and property features, and describe their synthetic methods and optical properties including strong absorption, photoluminescence, and phosphorescence. Furthermore, the recent significant advances in diverse applications, including optical (sensor, anticounterfeiting), energy (light-emitting diodes, catalysis, photovoltaics, supercapacitors), and promising biomedicine, are systematically highlighted. Finally, we envisage the key issues to be challenged, future research directions, and perspectives to show a full picture of CDs-based materials.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications

2020

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“…To solve the hypoxia problem, Wang's group [142] constructed the CDs/MnO 2 , MnO 2 can not only be reduced into Mn(II) by acidic H 2 O 2 as an T1 contrast agent for MRI but also generate oxygen within tumor to enhance the PDT efficiency. Magnetofluorescent Mn-CDs were prepared from Mn(II) phthalocyanine [143] and metal porphyrin [144][145][146]. After cooperative self-assembly with DSPE-PEG, the Mn-CDs aggregates can be used for bimodal contrast agent for MRI and fluorescence imaging agent.…”

Section: Fluorescent Cds Conjugated With Phototherapy Agent 521 Flmentioning

confidence: 99%

Recent advance of carbon dots in bio-related applications

Wang

Bao

et al. 2020

J. Phys. Mater.

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Carbon dots (CDs) is a kind of carbon nanoparticles with a plentiful of surface functional groups and tunable emission with different excitation wavelength. Broadly speaking, CDs include carbon nanodots, carbon quantum dots, graphene quantum dots, carbonized polymer dots. Due to the unique nature, they are explored for various applications in the bio-related fields such as bioimaging, sensor for ion and (bio)molecules, catalyst, LED and other fields. They are viewed as great alternative tracers to the current fluorescent biomarkers in personalized nanomedicine and surgery operation monitoring. In this review, we summarized the recent progress in the development of CDs, including improvement in fluorescence properties, two-photon fluorescence, and integration with other modalities as theragnostic agents. Specifically, we discussed the preparation of dual-modal imaging agents to improve the accuracy of diagnosis, the combination of imaging and targeting functionality for the effective accumulation of biomarkers, and the integration of imaging and therapeutic agents to effectively monitor the localization and concentration of therapeutic agents. Finally, the theragnostic agents composed of three functionalities (e.g. targeting, imaging, and therapy) were summarized to provide readers with future perspectives in this field.

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“…However, many of them are limited because of poor water solubility, prolonged cutaneous photosensitivity, inadequate selectivity, and their inability to be absorbed in the region (> 700 nm) where the skin is most transparent, which are encountered in clinical applications of numerous traditional chemicals. Therefore, numerous approaches have been proposed to incorporate PSs into carriers such as liposomes [ 12 ], polymeric nanoparticles [ 13 , 14 ], gold nanoparticles [ 15 – 17 ], carbon nanotubes [ 18 ], graphenes [ 19 ], and carbon nanodots [ 20 – 22 ].…”

Section: Introductionmentioning

confidence: 99%

Carbon Dots @ Platinum Porphyrin Composite as Theranostic Nanoagent for Efficient Photodynamic Cancer Therapy

Yue

et al. 2018

Nanoscale Res Lett

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Photosensitizers are light-sensitive molecules that are highly hydrophobic, which poses a challenge to their use for photodynamic therapy. Hence, considerable efforts have been made to develop carriers for the delivery of PSs. Herein, we synthesized a new theranostic nanoagent (CQDs@PtPor) through the electrostatic interaction between the tetraplatinated porphyrin complex (PtPor) and the negatively charged CQDs. The size and morphology of as-prepared CQDs and CQDs@PtPor were characterized by a series of methods, such as XRD, TEM, XPS, and FTIR spectroscopy. The CQDs@PtPor composite integrates the optical properties of CQDs and the anticancer function of porphyrin into a single unit. The spectral results suggested the effective resonance energy transfer from CQDs to PtPor in the CQDs@PtPor composite. Impressively, the CQDs@PtPor composite showed the stronger PDT effect than that of organic molecular PtPor, suggesting that CQDs@PtPor is advantageous over the conventional formulation, attributable to the enhanced efficiency of 1O2 production of PtPor by CQDs. Thus, this CQDs-based drug nanocarrier exhibited enhanced tumor-inhibition efficacy as well as low side effects in vitro, showing significant application potential in the cancer therapy.Electronic supplementary materialThe online version of this article (10.1186/s11671-018-2761-5) contains supplementary material, which is available to authorized users.

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Red/Near‐Infrared Emissive Metalloporphyrin‐Based Nanodots for Magnetic Resonance Imaging‐Guided Photodynamic Therapy In Vivo

Cited by 56 publications

References 43 publications

Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications

Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications

Recent advance of carbon dots in bio-related applications

Carbon Dots @ Platinum Porphyrin Composite as Theranostic Nanoagent for Efficient Photodynamic Cancer Therapy

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