Red light of a helium-neon laser reactivates superoxide dismutase

Gorbatenkova, E A; Vladimirov, Yu. A.; Paramonov, N. V.; Азизова, О. А.

doi:10.1007/bf00842048

Cited by 10 publications

(5 citation statements)

References 6 publications

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“…The most interesting experimental result obtained in the middle-IR region for certain irradiated samples was the increased absorption in the region 945-1280 cm -1 (Fig. 10c) [15] in bands at 965, 1047, 1081, and 1241 cm ) is due to a reduced contribution from the α-helical conformation and a possible configuration change of disulfide bridges in the protein molecules.…”

Section: Spectral Manifestations Of Photochemical Reactions Induced Bmentioning

confidence: 82%

“…The concentrations of free radicals formed chemically and new substances may be small because of the low photodissociation yields and the involvement of initially formed compounds in subsequent reactions. The content of triglycerides in plasma increased, the concentration of phospholipids decreased, and the concentration of cholesterol esters and certain other substances increased during a study of the products of secondary reactions of phototherapy [14,15,61]. It was expected that the concentration changes of certain molecular blood components would be sufficient to be evident in IR absorption spectra.…”

Section: Spectral Manifestations Of Photochemical Reactions Induced Bmentioning

confidence: 98%

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Molecular mechanisms of photochemotherapy (Review)

Zalesskayaa¹,

Улащик²

2009

J Appl Spectrosc

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Mechanisms of photophysical, photobiological, and therapeutic action of light on blood in vivo are discussed based on results of spectral and clinical studies of blood, plasma, and erythrocytes. Spectral manifestations of photochemical reactions initiated in blood by therapeutic doses of radiation in vivo with light of different wavelengths are considered. Spectral and clinical results of blood investigations are compared for patients whose complex treatment included intravenous blood irradiation and magnetotherapy. Mechanisms for secondary (dark) reactions induced by the action of light on blood in vivo are discussed. The radiation of laser and non-laser light sources used at present for intravenous blood irradiation (365, 405, 450, 530, 632, 635, 808 nm) is shown to fall within hemoglobin absorption bands. The conclusion is made that blood absorption of laser and non-laser light radiation results in functional alteration of hemoglobin as a possible primary photoacceptor absorbing light radiation of the above wavelengths. The therapeutic effect of intravenous blood irradiation is initiated by hemoglobin functional activity modulation. Phototherapy is a means to correct it. Intravenous phototherapy should be considered as a therapeutic method that changes (provided that the dosage is correct) the balance of active oxygen species production and their inhibition by antioxidants.

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Section: Spectral Manifestations Of Photochemical Reactions Induced Bmentioning

confidence: 82%

Section: Spectral Manifestations Of Photochemical Reactions Induced Bmentioning

confidence: 98%

Molecular mechanisms of photochemotherapy (Review)

Zalesskayaa¹,

Улащик²

2009

J Appl Spectrosc

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“…The resulting reduction of the pH-level in the myocardium tissues inhibits SOD activity. Low-intensive He-Ne laser radiation enhances SOD activity in vitro 17,18 . Relatively wide band luminescent red light (λ peak = 630 nm) could cause the similar effects.…”

Section: Discussionmentioning

confidence: 99%

“…Ischemia of heart muscle causes dramatic changes of the functional activity of myocardium 12 , damages of membranes of cardiac myocytes [13][14][15] and the increase of LPO level in the heart tissues [14][15][16] . At the same time, it is well known 17,18 that red laser light can reactivate the SOD enzyme and control activity of the lipid peroxidation processes in the sample tissues. These phenomena might be considered as the key mechanisms of the observed photo therapeutic effect of red light on living tissues.…”

Section: Introductionmentioning

confidence: 98%

Low-power light and isolated rat hearts after ischemia of myocardium

et al. 2010

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Total ischemia of myocardium has been simulated on isolated hearts of rats. Effects of a low-power HeNe laser (λ=632.8 nm) and a fiber optic photo-luminescent radiation source of red light ( λ of the spectral peak is equal to 630 nm) on isolated heart contractile function characteristics and on lipid peroxidation (LPO) level in myocardium tissues have been investigated. Two groups of the specimens have been irradiated with red light during the postischemia (reperfusion) period of time. The first group has been treated with laser light and the second one with the luminescent radiation. More rapid restoration of the speed of contraction, of the force of contraction, of the relaxation speed and of the heart rate with respect to the data of the control group has been observed in both experimental groups. The similar tendency was observed in the laser treated specimens. The effects of fibrillation of myocardium of isolated hearts irradiated by lowpower He-Ne laser light were observed. These effects could be caused by the local light fluence rate excess in the interference pattern of laser light diffracted on the heart muscle structures.

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“…Излучение в видимой области спектра, помимо тепловых эффектов, обеспечивает условия для стимуляции фотохимических реакций [22]. Пример активации каталазы в результате поглощения красного света гелий-неоновым лазером его хромофорной группой уже стал классическим [23,24]. При облучении глаз кроликов гелий-неоновым лазерным излучением (10 дней) в сетчатке и эпителиальном пигменте наблюдалось увеличение общего содержания групп SH и, соответственно, соотношения SH/SS, а также активности ферментов глутатионредуктазы, супероксиддисмутазы и каталазы в 1,5-2,5 раза [25].…”

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Adverse Health Effects of Exposure to Visible Laser Radiation in the General Population: A Review

Петрова¹,

Малькова²

2021

PH&LE

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Introduction: With the spread of laser technologies in various spheres of human activity, the number of exposures to laser radiation of a wide range of users unfamiliar with specifics of its health effects, including those in everyday life, has increased, thus resulting in an increased number of traumas in the general population in recent years. Objectives: To search for data on the biological mechanisms of action of visible laser radiation in Russian and foreign scientific literature and to analyze adverse health effects of this exposure encountered in domestic and international practice. Methods: We searched for Russian and foreign full-text open access literary sources in Russian Science Citation Index (RSCI) and PubMed databases of biomedical publications for 1969–2019 and selected the most appropriate ones for review. Results: Both Russian and foreign researchers note that human exposure to laser radiation induces specific and non-specific responses at all tissue levels of organization. The extent and nature of developing morphological changes depend on the radiation wavelength, exposure time, power, energy and its density per unit of the irradiated surface. Conclusions: Our findings suggest that portable laser pointers and powerful laser projectors may cause retinal damage, traumatic macular holes and, in some cases, loss of vision. Despite frequently registered good visual recovery, general availability of commercial laser devices poses potential danger, especially for minors, and substantiates the need to raise public awareness of laser safety.

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Red light of a helium-neon laser reactivates superoxide dismutase

Cited by 10 publications

References 6 publications

Molecular mechanisms of photochemotherapy (Review)

Molecular mechanisms of photochemotherapy (Review)

Low-power light and isolated rat hearts after ischemia of myocardium

Adverse Health Effects of Exposure to Visible Laser Radiation in the General Population: A Review

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