Low-power light and isolated rat hearts after ischemia of myocardium

Monich, V. A.; Drugova, Olga V.; Lazukin, V F; Bavrina, A. P.

doi:10.1117/12.840841

Cited by 3 publications

(2 citation statements)

References 13 publications

(18 reference statements)

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“…Indeed, a recent study using red light found acceleration of myocardial contractility recovery and reduction in the amount of molecular products of lipid peroxidation after ischemia. 75 Future studies directed toward the understanding of the circadian rhythm in cardioprotection, therefore, bear the potential to uncover novel, powerful, and easy applicable treatment options to prevent or ameliorate the consequences of myocardial I/R injury in a perioperative setting or in the context of acute MI.…”

Section: Metabolismmentioning

confidence: 99%

Myocardial Ischemia Reperfusion Injury

Frank

Bonney

et al. 2012

Semin Cardiothorac Vasc Anesth

390

186

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Myocardial ischemia reperfusion injury contributes to adverse cardiovascular outcomes after myocardial ischemia, cardiac surgery or circulatory arrest. Primarily, no blood flow to the heart causes an imbalance between oxygen demand and supply, named ischemia (from the greek isch-, restriction and -haema, blood), resulting in damage or dysfunction of the cardiac tissue. Instinctively, early and fast restoration of blood flow has been established to be the treatment of choice to prevent further tissue injury. Indeed, the use of thrombolytic therapy or primary percutaneous coronary intervention is the most effective strategy for reducing the size of a myocardial infarct and improving the clinical outcome. Unfortunately, restoring blood flow to the ischemic myocardium, named reperfusion, can also induce injury. This phenomenon was therefore termed myocardial ischemia reperfusion injury. Subsequent studies in animal models of acute myocardial infarction suggest that myocardial ischemia reperfusion injury accounts for up to 50% of the final size of a myocardial infarct. Consequently many researchers aim to understand the underlying molecular mechanism of myocardial ischemia reperfusion injury to find therapeutic strategies ultimately reducing the final infarct size. Despite of the identification of numerous therapeutic strategies at the bench, many of them are just in the process of being translated to bedside. In the current review, we will discuss the most striking basic science findings made during the last decades that are currently under clinical evaluation, with the ultimate goal to treat patients who are suffering from myocardial ischemia and reperfusion associated tissue injury.

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Section: Metabolismmentioning

confidence: 99%

Myocardial Ischemia Reperfusion Injury

Frank

Bonney

et al. 2012

Semin Cardiothorac Vasc Anesth

390

186

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show abstract

“…These effects can be provoked by not only ionizing radiation, but also experimental ischemia and reperfusion [12,13] of the myocardium and asphyxia [1]. Previous experiments [4,10] have demonstrated that consequences of oxidative stress can be fully or partly compensated by the exposure to low-intensity red light. Under these conditions, the contractive activity of isolated heart recovered.…”

Section: Resultsmentioning

confidence: 99%

Method for Correction of Consequences of Radiation-Induced Heart Disease using Low-Intensity Electromagnetic Emission under Experimental Conditions

et al. 2015

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Effects of successive exposure to ionizing irradiation and low-intensity broadband red light on electrical activity of the heart and myocardium microstructure were studied in rats. Lowintensity red light corrected some ECG parameters, in particular, it normalized QT and QTc intervals and voltage of R and T waves. Changes in ECG parameters were followed by alterations in microstructure of muscle fi laments in the myocardium of treatment group animals comparing to control group.

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A Role for Photobiomodulation in the Prevention of Myocardial Ischemic Reperfusion Injury: A Systematic Review and Potential Molecular Mechanisms

Liebert

Krause²,

Goonetilleke

et al. 2017

Sci Rep

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Myocardial ischemia reperfusion injury is a negative pathophysiological event that may result in cardiac cell apoptosis and is a result of coronary revascularization and cardiac intervention procedures. The resulting loss of cardiomyocyte cells and the formation of scar tissue, leads to impaired heart function, a major prognostic determinant of long-term cardiac outcomes. Photobiomodulation is a novel cardiac intervention that has displayed therapeutic effects in reducing myocardial ischemia reperfusion related myocardial injury in animal models. A growing body of evidence supporting the use of photobiomodulation in myocardial infarct models has implicated multiple molecular interactions. A systematic review was conducted to identify the strength of the evidence for the therapeutic effect of photobiomodulation and to summarise the current evidence as to its mechanisms. Photobiomodulation in animal models showed consistently positive effects over a range of wavelengths and application parameters, with reductions in total infarct size (up to 76%), decreases in inflammation and scarring, and increases in tissue repair. Multiple molecular pathways were identified, including modulation of inflammatory cytokines, signalling molecules, transcription factors, enzymes and antioxidants. Current evidence regarding the use of photobiomodulation in acute and planned cardiac intervention is at an early stage but is sufficient to inform on clinical trials.

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Low-power light and isolated rat hearts after ischemia of myocardium

Cited by 3 publications

References 13 publications

Myocardial Ischemia Reperfusion Injury

Myocardial Ischemia Reperfusion Injury

Method for Correction of Consequences of Radiation-Induced Heart Disease using Low-Intensity Electromagnetic Emission under Experimental Conditions

A Role for Photobiomodulation in the Prevention of Myocardial Ischemic Reperfusion Injury: A Systematic Review and Potential Molecular Mechanisms

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