Red Ginseng Extract Promotes the Hair Growth in Cultured Human Hair Follicles

Park, Gyeong-Hun; Park, Ki-young; Cho, Hong-Il; Lee, Sang‐Min; Han, Ji Su; Won, Chong Hyun; Chang, Sung Eun; Lee, Mi Woo; Choi, Jee Ho; Moon, Kee Chan; Shin, Hyun Sang; Kang, Yong‐Kook; Lee, Dong Hun

doi:10.1089/jmf.2013.3031

Cited by 53 publications

(40 citation statements)

References 50 publications

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“…The above results indicate that there is a close relationship between VEGF, P38 and ERK. P38 and ERK are two important proteins in the MAPK pathway, and AKT/PI3K has been associated with hair growth [ 32 , 33 ]. Thus, P38, ERK and AKT were chosen to assess the activation of P38/MAPK, ERK /MAPK and AKT/PI3K pathways in order to ascertain whether there is a relationship between Tβ4 and these signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

Thymosin Beta-4 Induces Mouse Hair Growth

et al. 2015

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Thymosin beta-4 (Tβ4) is known to induce hair growth and hair follicle (HF) development; however, its mechanism of action is unknown. We generated mice that overexpressed Tβ4 in the epidermis, as well as Tβ4 global knockout mice, to study the role of Tβ4 in HF development and explore the mechanism of Tβ4 on hair growth. To study Tβ4 function, we depilated control and experimental mice and made tissue sections stained with hematoxylin and eosin (H&E). To explore the effect of Tβ4 on hair growth and HF development, the mRNA and protein levels of Tβ4 and VEGF were detected by real-time PCR and western blotting in control and experimental mice. Protein expression levels and the phosphorylation of P38, ERK and AKT were also examined by western blotting. The results of depilation indicated that hair re-growth was faster in Tβ4-overexpressing mice, but slower in knockout mice. Histological examination revealed that Tβ4-overexpressing mice had a higher number of hair shafts and HFs clustered together to form groups, while the HFs of control mice and knockout mice were separate. Hair shafts in knockout mice were significantly reduced in number compared with control mice. Increased Tβ4 expression at the mRNA and protein levels was confirmed in Tβ4-overexpressing mice, which also had increased VEGF expression. On the other hand, knockout mice had reduced levels of VEGF expression. Mechanistically, Tβ4-overexpressing mice showed increased protein expression levels and phosphorylation of P38, ERK and AKT, whereas knockout mice had decreased levels of both expression and phosphorylation of these proteins. Tβ4 appears to regulate P38/ERK/AKT signaling via its effect on VEGF expression, with a resultant effect on the speed of hair growth, the pattern of HFs and the number of hair shafts.

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Section: Discussionmentioning

confidence: 99%

Thymosin Beta-4 Induces Mouse Hair Growth

et al. 2015

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“…Mey. has been revealed to promote HG [52][53][54]. Treatment of mice with RGO upregulates Wnt/β-catenin and Shh/Gli-pathways-mediated expression of genes such as β-catenin, Lef-1, sonic hedgehog, Cyclin D1, and Cyclin E [55].…”

Section: Panax Ginseng Ca Meymentioning

confidence: 99%

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Bassino

Gasparri

Munaron

2020

IJMS

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Hair loss is a disorder in which the hair falls out from skin areas such as the scalp and the body. Several studies suggest the use of herbal medicine to treat related disorders, including alopecia. Dermal microcirculation is essential for hair maintenance, and an insufficient blood supply can lead to hair follicles (HF) diseases. This work aims to provide an insight into the ethnohistorical records of some nutritional compounds containing flavonoids for their potential beneficial features in repairing or recovering from hair follicle disruption. We started from a query for “alopecia” OR “hair loss” AND “Panax ginseng C.A. Mey.“ (or other six botanicals) terms included in Pubmed and Web of Sciences articles. The activities of seven common botanicals introduced with diet (Panax ginseng C.A. Mey., Malus pumila Mill cultivar Annurca, Coffea arabica, Allium sativum L., Camellia sinensis (L.) Kuntze, Rosmarinum officinalis L., Capsicum annum L.) are discussed, which are believed to reduce the rate of hair loss or stimulate new hair growth. In this review, we pay our attention on the molecular mechanisms underlying the bioactivity of the aforementioned nutritional compounds in vivo, ex vivo and in vitro studies. There is a need for systematic evaluation of the most commonly used plants to confirm their anti-hair loss power, identify possible mechanisms of action, and recommend their best adoption.

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“…Dihydrotestosterone (DHT) is known to induce androgenic alopecia by shortening the hair follicle growth phase, resulting in hair loss. DHT damages DPCs by upregulation of Dickkopf 1 (DKK‐1), induction of cell death, increase in ROS and senescence in DPCs .A variety of compounds have demonstrated protective effect against DHT induced stress in DPCs .…”

Section: Protective Effect In Hair Growth Against Stressmentioning

confidence: 99%

Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth

Madaan

Verma

Singh

et al. 2018

Intern J of Cosmetic Sci

100

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Hair disorders such as hair loss (alopecia) and androgen dependent, excessive hair growth (hirsutism, hypertrichosis) may impact the social and psychological well-being of an individual. Recent advances in understanding the biology of hair have accelerated the research and development of novel therapeutic and cosmetic hair growth agents. Preclinical models aid in dermocosmetic efficacy testing and claim substantiation of hair growth modulators. The in vitro models to investigate hair growth utilize the hair follicle Dermal Papilla cells (DPCs), specialized mesenchymal cells located at the base of hair follicle that play essential roles in hair follicular morphogenesis and postnatal hair growth cycles. In this review, we have compiled and discussed the extensively reported literature citing DPCs as in vitro model to study hair growth promoting and inhibitory effects. A variety of agents such as herbal and natural extracts, growth factors and cytokines, platelet-rich plasma, placental extract, stem cells and conditioned medium, peptides, hormones, lipid-nanocarrier, light, electrical and electromagnetic field stimulation, androgens and their analogs, stress-serum and chemotherapeutic agents etc. have been examined for their hair growth modulating effects in DPCs. Effects on DPCs' activity were determined from untreated (basal) or stress induced levels. Cell proliferation, apoptosis and secretion of growth factors were included as primary end-point markers. Effects on a wide range of biomolecules and mechanistic pathways that play key role in the biology of hair growth were also investigated. This consolidated and comprehensive review summarizes the up-to-date information and understanding regarding DPCs based screening models for hair growth and may be helpful for researchers to select the appropriate assay system and biomarkers. This review highlights the pivotal role of DPCs in the forefront of hair research as screening platforms by providing insights into mechanistic action at cellular level, which may further direct the development of novel hair growth modulators.

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Red Ginseng Extract Promotes the Hair Growth in Cultured Human Hair Follicles

Cited by 53 publications

References 50 publications

Thymosin Beta-4 Induces Mouse Hair Growth

Thymosin Beta-4 Induces Mouse Hair Growth

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth

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