Red ginseng-derived saponin fraction suppresses the obesity-induced inflammatory responses via Nrf2-HO-1 pathway in adipocyte-macrophage co-culture system

Kim, Chae Young; Kang, Bobin; Suh, Hyung Joo; Hyun-Min, Choi

doi:10.1016/j.biopha.2018.09.169

Cited by 26 publications

(15 citation statements)

References 41 publications

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“…Ginsenoside Re enhanced the activation of Nrf2 in Aβ-induced SH-SY5Y cells [76]. The activation of the Nrf2-HO-1 pathway for M2 macrophage polarization is also supported by the findings that a red ginseng-derived saponin fraction suppressed inflammatory responses via the Nrf2-HO-1 pathway in an adipocyte-macrophage co-culture system [42], and that saponins from Panax notoginseng acted as an extrinsic regulator that activates the Nrf2 antioxidant defense system and inhibits NF-κB inflammatory signaling to attenuate LPS-induced monocyte adhesion on cerebral endothelial cells [77].…”

Section: Perspectivementioning

confidence: 65%

“…For the mechanism of ginseng anti-inflammation, several targets were proposed: (1) activation of the glucocorticoid receptor, the target of steroidal anti-inflammatory drugs such as cortisol and dexamethasone (compound K, ginsenosides Rg1 and Re) [36][37][38][39]; (2) an anti-oxidation-related mechanism, i.e., inhibition of ROS production and activation of Nrf-2 and HO-1 (compound K, ginsenosides Rg1, Rb1, Ro, and Rg5) [27,33,36,[40][41][42]; (3) blocking of TLR4 interaction with LPS (ginsenosides Re and Rg5) [43,44]; (4) activation of anti-inflammatory PPARγ (ginsenosides Rg3, Re, Rb1, Rg1, and Rf) [40,[45][46][47][48][49][50].…”

Section: Ginsenosides In Anti-inflammationmentioning

confidence: 99%

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Pro-Resolving Effect of Ginsenosides as an Anti-Inflammatory Mechanism of Panax ginseng

2020

Biomolecules

120

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Panax ginseng, also known as Korean ginseng, is a famous medicinal plant used for the treatment of many inflammatory diseases. Ginsenosides (ginseng saponins) are the main class of active constituents of ginseng. The anti-inflammatory effects of ginseng extracts were proven with purified ginsenosides, such as ginsenosides Rb1, Rg1, Rg3, and Rh2, as well as compound K. The negative regulation of pro-inflammatory cytokine expressions (TNF-α, IL-1β, and IL-6) and enzyme expressions (iNOS and COX-2) was found as the anti-inflammatory mechanism of ginsenosides in M1-polarized macrophages and microglia. Recently, another action mechanism emerged explaining the anti-inflammatory effect of ginseng. This is a pro-resolution of inflammation derived by M2-polarized macrophages. Direct and indirect evidence supports how several ginsenosides (ginsenoside Rg3, Rb1, and Rg1) induce the M2 polarization of macrophages and microglia, and how these M2-polarized cells contribute to the suppression of inflammation progression and promotion of inflammation resolution. In this review, the new action mechanism of ginseng anti-inflammation is summarized.

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Section: Perspectivementioning

confidence: 65%

Section: Ginsenosides In Anti-inflammationmentioning

confidence: 99%

Pro-Resolving Effect of Ginsenosides as an Anti-Inflammatory Mechanism of Panax ginseng

2020

Biomolecules

120

View full text Add to dashboard Cite

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“…HO-1 upregulation has also been linked to increased insulin sensitivity, improvement in phosphorylation of insulin receptors, and improved adipocyte function [35]. Previously published studies have shown the protective role of HO-1 in inhibiting the inflammatory effect of several mediators; inflammatory and oxidative transcription factors, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κβ) and c-Jun N-terminal kinase (JNK), which are primarily involved in inflammatory insult, stimulate inflammatory pathways, creating a feedback mechanism of inflammation [35,54,56]. Evidence from the literature suggests a potential interaction between HO-1 and adiponectin.…”

Section: The Na/k-atpase Oxidant Amplification Loop and Ho-1: Implicamentioning

confidence: 99%

Section: Approaches To Targeted Upregulation Of Ho-1mentioning

confidence: 99%

“…Cobalt protoporphyrin (CoPP) is an exogenous inducer of HO-1 that theoretically acts through the FoxO1 protein [54,56,69]. Current literature hypothesizes that FoxO1 negatively regulates adipogenesis by preventing transcription of PPARγ; decreased adipogenesis leads to a decrease in systemic oxidative stress and inflammatory cytokines [36,56]. Previous studies have shown that HO-1 induction by CoPP reduces visceral adiposity and attenuates metabolic imbalance, increases levels of phosphorylated AKT, AMPK, mTOR in adipocytes, improved oxidative stress, decreased release of inflammatory cytokines, decreased lipid accumulation and increased adiponectin levels [36,55,70].…”

Section: Approaches To Targeted Upregulation Of Ho-1mentioning

confidence: 99%

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Mechanistic Insight of Na/K-ATPase Signaling and HO-1 into Models of Obesity and Nonalcoholic Steatohepatitis

Pratt

Lakhani

Zehra

et al. 2019

IJMS

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Obesity is a multifaceted pathophysiological condition that has been associated with lipid accumulation, adipocyte dysfunction, impaired mitochondrial biogenesis and an altered metabolic profile. Redox imbalance and excessive release of inflammatory mediators have been intricately linked in obesity-associated phenotypes. Hence, understanding the mechanisms of redox signaling pathways and molecular targets exacerbating oxidative stress is crucial in improving health outcomes. The activation of Na/K-ATPase/Src signaling, and its downstream pathways, by reactive oxygen species (ROS) has been recently implicated in obesity and subsequent nonalcoholic steatohepatitis (NASH), which causes further production of ROS creating an oxidant amplification loop. Apart from that, numerous studies have also characterized antioxidant properties of heme oxygenase 1 (HO-1), which is suppressed in an obese state. The induction of HO-1 restores cellular redox processes, which contributes to inhibition of the toxic milieu. The novelty of these independent mechanisms presents a unique opportunity to unravel their potential as molecular targets for redox regulation in obesity and NASH. The attenuation of oxidative stress, by understanding the underlying molecular mechanisms and associated mediators, with a targeted treatment modality may provide for improved therapeutic options to combat clinical disorders.

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The effects of ginseng on the metabolic syndrome: An updated review

Aminifard

Razavi

Hosseinzadeh

2021

Food Science & Nutrition

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Metabolic syndrome or syndrome X is the name given to the collection of clinical conditions including overweight, high blood pressure, high blood glucose (or type 2 diabetes mellitus), and hyperlipidemia (Chen et al., 2017).Metabolic syndrome is the most important risk factor for atherosclerosis in response to chronic inflammation and vascular endothelial dysfunction. Metabolic syndrome increases the risk of cardiovascular diseases. Cardiovascular diseases are the main reasons for mortality around the world . The metabolic syndrome is rising due to a sedentary lifestyle. Children, adolescents, and young women with polycystic ovary syndrome are at risk for metabolic syndrome (Vassallo et al., 2016).Medicine herbs, because of their potential efficacy in improving and holding human health, low cost, and adverse effects, have been the focus of attention. Studies have been shown that several plants and their active constituents can exert beneficial effects on metabolic syndrome. For example, grapes (Vitis vinifera), a source of polyphenol antioxidants, is useful for preventing the risk factors involved in metabolic syndromes such as hyperlipidemia, hypertension, and hyperglycemia (Akaberi & Hosseinzadeh, 2016). Garlic (Allium sativum) has been documented in the treatment of metabolic syndrome as it showed hypoglycemic, hypotensive, and hypolipidemic activities (Hosseini & Hosseinzadeh, 2015). Rosemary (Rosmarinus officinalis L.) is a source of phenolic phytochemicals having considerable anti-inflammatory, antioxidant, hypoglycemic, hypolipidemic, and hypotensive effects (Hassani et al., 2016).

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Red ginseng-derived saponin fraction suppresses the obesity-induced inflammatory responses via Nrf2-HO-1 pathway in adipocyte-macrophage co-culture system

Cited by 26 publications

References 41 publications

Pro-Resolving Effect of Ginsenosides as an Anti-Inflammatory Mechanism of Panax ginseng

Pro-Resolving Effect of Ginsenosides as an Anti-Inflammatory Mechanism of Panax ginseng

Mechanistic Insight of Na/K-ATPase Signaling and HO-1 into Models of Obesity and Nonalcoholic Steatohepatitis

The effects of ginseng on the metabolic syndrome: An updated review

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