Red Cell Polymorphisms in Sardinia

Rickards, Olga; Biondi, G.; Fuciarelli, Maria; Capucci, Enrico; Walter, H.; Stefano, G. F. De

doi:10.1159/000153810

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…This is corroborated by the statistical analysis of Rickards et al, 1988;Walter et al, 1989) thus indicating a considerable genetic heterogeneity of the Sardinian population. This confirms, too, the observations of Piazza et al (1985) and Ulizzi et al (1988), who investigated the distribution of numerous genetic markers on this island and showed that the genetic differentiation within Sardinia is relatively high.…”

Section: Methodssupporting

confidence: 57%

“…As part of a joint research project on the regional variability of genetic markers in Italy, we typed four Sardinian population samples for various red cell enzyme (AcP, EsD, PGM,) and serum protein (Hp, Tf-, Gc-, Pi-subtypes) polymorphisms (De Stefan0 et al, 1987;Rickards et al, 1988;Walter et al, 19891, including Gm and Km allotypes. The results of these Gm and Km typings will be presented here, followed by a critical review of the hitherto reported Gm-and Km-data from Italy.…”

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confidence: 99%

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Gm and Km allotypes in four Sardinian population samples

Walter

Matsumoto

Stefano

1991

American J Phys Anthropol

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Serum samples of 683 unrelated male and female individuals of four Sardinian population samples (Sassari, Nuoro, Oristano and Cagliari) were typed for G 1 m (1,2,3,17), G 3 m (5,6,10,11,13,14,15,16,21,26), and Km (1). Phenotype, haplotype (Gm), and allele frequencies (Km), respectively, show a remarkable variability between these four population samples. Comparisons with other Italian populations reveal the considerable genetic difference of the Sardinians, which is in particular caused by the presence of the haplotype Gm1,3;5,10,11,13,14,26 in them. This haplotype is quite uncommon in Europeans and may reflect gene flow from Eastern populations (Phoenicians?) who came to this island in ancient-history times.

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Section: Methodssupporting

confidence: 57%

mentioning

confidence: 99%

Gm and Km allotypes in four Sardinian population samples

Walter

Matsumoto

Stefano

1991

American J Phys Anthropol

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“…Sardinians may constitute a unique pre-Indo-European population (Rickards et al, 1988). According to Contu et al (1992) by an intrinsic internal heterogeneity.…”

Section: Genetic Variability and Differentiation Of Sardiniamentioning

confidence: 99%

Review Synthetic Article: Sardinian Population (Italy): a Genetic Review

Calò¹,

Melis²,

Vona³

et al. 2010

Int.J.Mod.Anthrop

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-For years the population of Sardinia has been object of numerous studies in the fields of anthropology and population genetics. Researches on genetic structure of Sardinian population, performed with of both classical and DNA markers, revealed an extremely complex picture of the relationships between Sardinian and other Italian and Mediterranean populations, that can be explained by Sardinian's historical and demographic past. A high degree of internal heterogeneity was also found and it can be attributed first to strict isolation and consequent high levels of endogamy and consanguinity, secondly, to selective factor linked to endemic malaria that influenced the distribution of some gene frequencies. Finally an influence on Sardinian's biological history could be attributed to the demographic events such as low population density and scant matrimonial movement, which triggered off phenomena of genetic drift.

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