Red cell metabolism in iron deficiency anemia

Macdougall, Lorna G.

doi:10.1016/s0022-3476(72)80130-6

Cited by 43 publications

(19 citation statements)

References 31 publications

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“…We identified that anemic dogs had significantly decreased whole blood activity of the antioxidant enzyme, glutathione peroxidase, when compared to healthy control dogs. This finding is similar to that in humans, in which a deficiency in GPx is associated with hemolytic anemia, iron deficiency anemia, and anemia of other causes . The mature erythrocyte depends upon nonoxidative metabolism for its major energy supply and is equipped with protective mechanisms against oxidant damage to its cell membrane, hemoglobin, and essential enzyme systems .…”

Section: Discussionsupporting

confidence: 82%

“…This finding is similar to that in humans, in which a deficiency in GPx is associated with hemolytic anemia, iron deficiency anemia, and anemia of other causes . The mature erythrocyte depends upon nonoxidative metabolism for its major energy supply and is equipped with protective mechanisms against oxidant damage to its cell membrane, hemoglobin, and essential enzyme systems . One such mechanism is GPx, which permits reversible oxidation of glutathione (GSH) when the erythrocyte is exposed to oxidant compounds.…”

Section: Discussionsupporting

confidence: 77%

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Glutathione Peroxidase Activity, Plasma Total Antioxidant Capacity, and Urinary F2‐ Isoprostanes as Markers of Oxidative Stress in Anemic Dogs

Kendall

Woolcock

Brooks

et al. 2017

Veterinary Internal Medicne

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BackgroundOxidative stress plays a role in the pathophysiology of several diseases and has been documented as a contributor to disease in both the human and veterinary literature. One at‐risk cell is the erythrocyte, however, the role of oxidative stress in anemia in dogs has not been widely investigated.Hypothesis/ObjectiveAnemic dogs will have an alteration in the activity of glutathione peroxidase (GPx), a decrease in of total antioxidant capacity (TAC), and an increased concentration of urinary 15‐F2‐isoprostanes (F2‐IsoP) when compared to healthy dogs.Animals40 client‐owned dogs with anemia (PCV <30%) age‐matched to 40 client‐owned healthy control dogs.MethodsProspective, cross‐sectional study. Whole blood GPx activity, plasma TAC, and urinary F2‐isoprostane concentrations were evaluated in each dog and compared between groups.ResultsAnemic dogs had significantly lower GPx activity (43.1 × 103 +/‐ 1.6 × 103 U/L) than did dogs in the control group (75.8 × 103 +/‐ 2.0 × 103 U/L; P < 0.0001). The GPx activity in dogs with hemolysis (103 +/‐ 0.8 × 103 U/L) was not significantly different (P = 0.57) than in dogs with nonhemolytic anemia (43.5 × 103 +/‐ 1.1 × 103 U/L). The TAC concentrations (P = 0.15) and urinary F2‐isoprostanes (P = 0.73) did not significantly differ between groups.Conclusions and Clinical ImportanceGlutathione peroxidase activity was significantly decreased in anemic dogs indicating oxidative stress. Additional studies are warranted to determine if antioxidant supplementation would improve survival and overall outcome as part of a therapeutic regimen for anemic dogs.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 77%

Glutathione Peroxidase Activity, Plasma Total Antioxidant Capacity, and Urinary F2‐ Isoprostanes as Markers of Oxidative Stress in Anemic Dogs

Kendall

Woolcock

Brooks

et al. 2017

Veterinary Internal Medicne

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“…However, most previous studies have been conducted in humans or animals with iron-deficiency anemia and not in subjects in the early stages of iron deficiency (i.e., with depleted stores and no anemia). Iron-deficiency anemia has been demonstrated to decrease tissue selenium concentrations in rats (20,25) and humans (36), as well as to decrease the activity and/or concentration of selenium-dependent glutathione peroxidase in rabbits (23), rats (20,25), and humans (19,22,27,36,37). Thus, it appears that in states of iron-deficiency anemia, in which typically both storage and functional iron deficits are present, selenium metabolism is affected, whereas in the present study with low iron stores, functional or transport iron appears to have been sufficient to maintain normal selenium metabolism.…”

Section: Discussionmentioning

confidence: 99%

“…Some effects of iron-deficiency anemia include impaired immune function and cognitive performance, and alterations in behavior, thermoregulation, energy metabolism, and exercise performance (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Additionally, irondeficiency anemia has been shown to alter tissue concentrations of minerals other than iron such as selenium and copper and to alter the activities or concentrations of non-iron-dependent enzymes, especially those with antioxidant functions (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). Moreover, iron-deficiency anemia has been found to increase red blood cell susceptibility to oxidation in vitro (28).…”

Section: Introductionmentioning

confidence: 99%

Iron Depletion without Anemia Is Not Associated with Impaired Selenium Status in College-Aged Women

McAnulty

Gropper

McAnulty

et al. 2003

BTER

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Iron-deficiency anemia has been shown to alter body mineral concentrations and activities of iron- and non-iron-containing enzymes, especially those with antioxidant functions. These effects, however, have been less studied in nonanemic iron-depleted individuals. Thus, this study assessed indices of selenium status in 12 college-aged females with adequate iron stores and 15 college-aged females with low iron stores before and after iron therapy. Blood samples were drawn at baseline for both groups and following iron supplementation in the low-iron-stores group. Hematocrit, hemoglobin, and serum ferritin concentrations of the low iron- stores group were significantly lower than those of the control group. The serum transferrin receptor-to-serum ferritin ratio in the low-iron stores group was significantly greater than that of the control group. Serum selenium and glutathione peroxidase concentrations of the low-iron-stores group were not significantly different from those of the controls. Iron supplementation significantly increased hemoglobin, hematocrit, and serum ferritin concentrations and significantly decreased the serum transferrin receptor concentration and serum transferrin receptor:serum ferritin ratio in the low-iron-stores group posttreatment compared to pretreatment. Serum selenium and glutathione peroxidase concentrations did not differ significantly from pretreatment to posttreatment in the low-iron-stores group. Results of this study indicate that low iron stores without anemia are not associated with impaired selenium status in college-aged females.

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“…The selenium-iron interaction is supported by many human and animal studies. A positive correlation was found between the plasma selenium level and * Correspondence: Dr Marja Mutanen, University of Helsinki, 00710 Helsinki, Finland. the haematocrit and haemoglobin concentrations in some population groups (Perona etal., 1977; Deguchi, 1985) and anaemic humans were shown to display a low erythrocyte glutathione peroxidase activity (MacDougall, 1972). Morris and coworkers (Morris et al, 1984) reported that selenium supplementation reduced the incidence of anaemia in grazing beef cattle, and iron deficiency in rabbits produced by phlebotomy resulted in lowered erythrocyte glutathione peroxidase activity (Rodvien, Gillum & Weintraub, 1974).…”

Section: Introductionmentioning

confidence: 99%

Selenium‐iron interaction in young women with low selenium status

Viita

Mutanen

Mykkänen

1989

J Human Nutrition Diet

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The effect of inorganic selenium (Se) supplementation on iron status and iron supplementation on selenium status was investigated in Finnish female students (=33). The students were divided into three groups and supplemented daily for four weeks either with 150 μg Se as sodium selenate, or 120 mg Fe as ferrous sulfate, or 120 mg Fe as ferrous sulfate and 150 μg Se as sodium selenate. Plasma selenium level was used as an indicator of body selenium status. Haematocrit and serum ferritin concentrations were measured to determine the changes in body iron status. The initial plasma selenium level of all subjects was 74.7 ± 2.9 ng/ml (mean ± SEM). The increase in the plasma Se level in the group receiving sodium selenate was significantly higher (P<0.05) than in the group having both sodium selenate and ferrous sulphate. The plasma selenium level in the group receiving ferrous sulphate decreased from 76.0 ± 2.8 ng/ml to 67.8 ± 2.3 (P<0.05) during the supplementation period, but returned to the initial level four weeks after the end of iron supplementation. The data indicate that the supplementary iron affected adversely the body selenium status of these subjects. On the other hand, Se supplementation had no effect on body iron status as indicated by the serum ferritin and haematocrit levels. It was also shown that there was no obvious interaction between the normal levels of selenium and iron in the body, since no correlations were found between plasma selenium and serum ferritin (r = 0.30, P>0.05) in the beginning of the study.

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Red cell metabolism in iron deficiency anemia

Cited by 43 publications

References 31 publications

Glutathione Peroxidase Activity, Plasma Total Antioxidant Capacity, and Urinary F2‐ Isoprostanes as Markers of Oxidative Stress in Anemic Dogs

Glutathione Peroxidase Activity, Plasma Total Antioxidant Capacity, and Urinary F2‐ Isoprostanes as Markers of Oxidative Stress in Anemic Dogs

Iron Depletion without Anemia Is Not Associated with Impaired Selenium Status in College-Aged Women

Selenium‐iron interaction in young women with low selenium status

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