Red cell metabolism in iron deficiency anemia. II. The relationship between red cell survival and alterations in red cell metabolism

Macdougall, Lorna G.; Judisch, Janifer M.; Mistry, Silloo B.

doi:10.1016/s0022-3476(70)80283-9

Cited by 30 publications

(22 citation statements)

References 47 publications

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“…Both parameters are closely associated and may be regarded as reliable parameters for guidance of iron therapy . In studies of pediatric anemia following blood loss, elevated hypochromic RBC was associated with shortened RBC survival, indicating the relevance of RBC Hb content for RBC survival times …”

Section: Discussionmentioning

confidence: 99%

“…33,34 In studies of pediatric anemia following blood loss, elevated hypochromic RBC was associated with shortened RBC survival, indicating the relevance of RBC Hb content for RBC survival times. 35 In patients with very low Hb and high EPO requirements, hypochromic RBC and reticulocytes can be examined in response to graded doses of vitamin C, in order to establish a dose-response for rational use of vitamin C in anemia management. Vitamin C can be measured prior to start of therapy, and patients with chronically low levels of vitamin C are of special interest in this regard, which highlights the utility of adding routine vitamin C assessment to the ESRD clinical panel.…”

Section: Discussionmentioning

confidence: 99%

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Plasma vitamin C levels in ESRD patients and occurrence of hypochromic erythrocytes

Seibert

Richter²,

Kuhlmann

et al. 2016

Hemodialysis International

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Plasma vitamin C levels in ESRD patients and occurrence of hypochromic erythrocytes

Seibert

Richter²,

Kuhlmann

et al. 2016

Hemodialysis International

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“…On the other hand, several glycolytic enzymes as well as hexose mono phosphate shunt enzymes, which ensure adequate NADH and NADPH levels, have increased activity, with possible implication in antioxidant defense mechanisms [16]. Some of the patients have reduced red-cell survival, demon strated by radioactive tagging studies [17]. The direct cause for the shortened survival is not known.…”

Section: Discussionmentioning

confidence: 99%

Iron Deficiency Anemia: Recovery from in vitro Oxidative Stress

et al. 1993

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Red blood cells in iron deficiency anemia (IDA) have a decreased activity of essential antioxidant enzymes. The present study examined the effect of in vitro exposure to oxidative agents in IDA cells and their recovery capacity. Red cells of 26 IDA patients and 10 healthy subjects were examined. Cells of IDA patients had higher levels of reduced glutathione (GSH), and normal methemoglobin and malonyldialdehyde (MDA) levels. Exposure to butyl hydro-peroxide revealed a dose-dependent sensitivity in IDA cells, with extensive GSH depletion and increased MDA levels. These changes were partially reversible by incubation with dithiothreitol. Exposure to phenazine methosulfate, to produce intracellular superoxide ions, resulted in moderate GSH depletion and methemoglobin production. IDA cells were more sensitive than control cells to high concentrations of this substance. This effect was further augmented by preincubation with a superoxide dismutase inhibitor. Our data demonstrate that IDA cells are more susceptible to oxidation but have good capacity for recovery.

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“…Iron deficiency anemia is caused by a decrease in Hb production, but also by a shortening of the red cell life span [1,2], Previous studies suggest that the de creased red cell survival is secondary to an increased susceptibility of the red cell to oxidant stress [3,4].…”

Section: Introductionmentioning

confidence: 99%