Red cell distribution width (RDW) changes in pregnancy

Shehata, Hassan; Ali, Mariam; Evans-Jones, J.; Upton, Graham; Manyonda, Isaac

doi:10.1016/s0020-7292(98)00069-1

Cited by 39 publications

(29 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Third, elevated RDW levels are observed in many clinical settings including increased red cell destruction after transfusion, hemolysis and in the setting of ineffective red cell production such as that of iron deficiency, vitamin B12 or folate. Levels of RDW are also elevated during several clinical conditions such as inflammatory bowel diseases, thrombotic thrombocytopenic purpura and pregnancy [28][29][30]. Hemoglobin was the only measured factor in this study, while other factors were not measured, including vitamin B12, iron and folate.…”

Section: Limitations Of the Studymentioning

confidence: 61%

The impact of admission red cell distribution width on long-term cardiovascular events after primary percutaneous intervention: A four-year prospective study

et al. 2016

View full text Add to dashboard Cite

show abstract

Section: Limitations Of the Studymentioning

confidence: 61%

The impact of admission red cell distribution width on long-term cardiovascular events after primary percutaneous intervention: A four-year prospective study

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In the literature, there is only limited data on the influence of normal pregnancy on RDW. Between 16 and 34 weeks of gestation, it is stable (27), but between 34 weeks of gestation and the onset of labor, high RDW values have been reported (28). Similar to the relationship of inflammation with increased RDW values in hypertensive non-pregnant women, inflammatory theory has been also blamed for increased RDW values preeclamptic women.…”

Section: Discussionmentioning

confidence: 92%

Erythrocyte Indices in Patients with Preeclampsia

Avcıoğlu¹,

Sezer²,

Altınkaya³

et al. 2015

meandros

View full text Add to dashboard Cite

Objective: The purpose of study was to investigate erythrocyte indices in patients with preeclampsia. Materials and Methods:The study population consisted of 102 patients with preeclampsia (49 mild, 53 severe preeclampsia) and 98 control pregnant patients. For the entire study population, red blood cell indices, including baseline mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), and red blood cell (RBC) were measured by using an automatic blood counter. Results: In the preeclampsia group, the median RDW was 15% (13.8-16.57), whereas in the control group it was 13.9% (13-15.6) (p<0.01). On the other hand, the mean MCV value was 80.42±7.86 (fL) in preeclampsia group and 83.88±2.31 (fL) in control group (p=0.003). Besides, the mean MCHC value was 33.66±1.71 (g/dL) in preeclampsia group and 33.09±1.48 (g/dL) in control group (p=0.012). However MCH and RBC values were not statistically different between the groups. (p>0.05) Moreover, subgroup analysis revealed that RDW levels were significantly increased in preeclampsia subjects than in mild preeclampsia patients (15.4% (13.9-17.45) vs 14.3% (13.7-15.7), p=0.031), MCV levels were decreased (78.81±7.91 (fL) vs 82.16± 7.43 (fL), p=0.03), RBC values were increased (4.16 (3.79-4.85)x(10 12 /L) vs 3.82 (3.45-4.34)x(10 12 /L), (p=0.006)) in patients with severe preeclampsia when compared to the patients with mild preeclampsia. In the receiver operator characteristic (ROC) analysis of subjects with and without preeclampsia, RDW and MCV showed high predictive values (p<0.01). Besides, in ROC analysis of preeclampsia patients with different severities, RDW and RBC showed the ideal predictive values (p=0.006, p=0.031, respectively). Conclusion: Our study results revealed that among the red blood cell indices, only increased RDW values were associated with both the presence and the severity of preeclampsia.Amaç: Bu çalışmanın amacı preeklampsi tanısı konmuş hastalarda eritrosit indekslerini araştırmaktır. Gereç ve Yöntemler: Bu çalışmaya 102 preeklampsi (49 hafif ve 53 şiddetli preeklampsi olmak üzere) ve 98 kontrol hastası dahil edilmiştir. Tüm çalışma grubunda eritrosit indeksleri olan ortalama korpuskular hacim (MCV), ortalama korpuskular hemoglobin (MCH), ortalama korpuskular hemoglobin konsantrasyonu (MCHC), eritrosit sayımı ve eritrosit dağılım genişliği değerleri otomatik kan sayım cihazı ile ölçüldü.Ad dress for Cor res pon den ce/Ya zış ma Ad re si:

show abstract

“…Finally, the study primary endpoint-related ROC curves parameters of NYHA functional class, LVEF, PWT, LV mass index, age, mitral regurgitation grade, eGFR, left atrial volume, E/A ratio, LVEDD, and RDW>14.45% variation of the red cell mean corpuscular volume (MCV) and its normal values range from 12 to 17% [1]. Typically, RDW increases in haemolytic diseases, conditions causing reticulocytosis, thrombotic thrombocytopenic purpura, inflammatory bowel diseases, and pregnancy [2][3][4][5][6]. However, recently, RDW has been found a good predictor marker for heart failure (HF) patients with reduced left ventricular ejection fraction (LVEF) (CHARM study) [7], with preserved LVEF [8], and for subject with prior myocardial infarction without HF (CARE study) [9].…”

Section: Resultsmentioning

confidence: 99%

Red cell distribution width and chronic heart failure: prognostic role beyond echocardiographic parameters

Vizzardi

Sciatti

Bonadei

et al. 2016

Monaldi Arch Chest Dis

View full text Add to dashboard Cite

Aim. Red cell distribution width (RDW) is a measure of anisocytosis. Higher values are robustly associated to adverse outcome in several conditions, including chronic heart failure (HF). The present study aimed to compared its prognostic role with that of echocardiographic parameters in this kind of patients.Methods. 232 stable and optimally treated chronic HF patients were enrolled. We excluded subjects suffering from valvular diseases or atrial fibrillation. They underwent blood sampling and echocardiographic examination. The primary endpoint of the study was cardiovascular death and/or HF hospitalization in the first year after enrolment.Results. 49 patients reached the primary endpoint. RDW best cut-off at ROC curve was 14.45%. Univariate analysis associated mitral regurgitation grade, left ventricular ejection fraction (LVEF), posterior wall thickness (PWT), LV mass index, and RDW>14.45% to the primary endpoint. Multivariate regression analysis showed that LVEF, PWT, and RDW>14.45% predict the primary endpoint. Area under ROC curve was 0.808 for LVEF, 0.762 for NYHA class, and 0.761 for RDW.Conclusion. In chronic HF patients RDW is a better predictor of adverse outcome than several echocardiographic parameters associated to outcome itself (LV mass index, mitral regurgitation grade), predicts prognosis even adjusting for those parameters, age and NYHA class, and is associated to several echocardiographic measurements. In conclusion, RDW can expand our tool bag in order to better follow-up these patients. RiassuntoScopo. Il red cell distribution width (RDW) è una misura di anisocitosi. Valori elevati sono fortemente associati ad esiti sfavorevoli in plurime condizioni, tra cui lo scompenso cardiaco (SC) cronico. Lo scopo di questo studio era paragonare il suo ruolo prognostico con quello dei parametri ecocardiografici in questo tipo di pazienti.Metodi. Sono stati arruolati 232 pazienti affetti da SC cronico, stabili e con terapia ottimizzata. Sono stati esclusi i soggetti con valvulopatie o fibrillazione atriale. I pazienti sono stati sottoposti a prelievo di sangue ed ecocardiogramma. L'endpoint primario dello studio consisteva in morte cardiovascolare e/o ospedalizzazione per SC entro un anno dall'arruolamento.Risultati. 49 pazienti hanno raggiunto l'endpoint primario. Il miglior cut-off di RDW alla curva ROC è stato 14.45%. L'analisi uni variata ha associato il grado di insufficienza mitralica, la frazione di eiezione ventricolare sinistra (FEVS), lo spessore della parete posteriore del ventricolo sinistro (PP), la massa ventricolare sinistra indicizzata e RDW>14.45% all'endpoint primario. La regressione multivariata ha mostrato che FEVS, PP e RDW>14.45% predicono l'endpoint primario. L'area sotto la curva ROC è risultata 0.808 per la FEVS, 0.762 per la classe NYHA e 0.761 per l'RDW.Conclusione. In pazienti con SC cronico l'RDW è un miglior predittore di outcome sfavorevole rispetto a numerosi parametri ecocardiografici associati allo stesso outcome (massa ventricolare sinistra indicizzata, grado d...

show abstract

Red cell distribution width (RDW) changes in pregnancy

Cited by 39 publications

References 7 publications

The impact of admission red cell distribution width on long-term cardiovascular events after primary percutaneous intervention: A four-year prospective study

The impact of admission red cell distribution width on long-term cardiovascular events after primary percutaneous intervention: A four-year prospective study

Erythrocyte Indices in Patients with Preeclampsia

Red cell distribution width and chronic heart failure: prognostic role beyond echocardiographic parameters

Contact Info

Product

Resources

About