Red cell distribution width is associated with incident venous thromboembolism (VTE) and case-fatality after VTE in a general population

Ellingsen, Trygve; Lappegård, Jostein; Skjelbakken, Tove; Brækkan, Sigrid Kufaas; Hansen, John‐Bjarne

doi:10.1160/th14-04-0335

Cited by 30 publications

(22 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results suggest that high body iron stores may increase the risk of VTE. In agreement with previous studies, 16,17 we demonstrated a doseresponse relationship between RDW and risk of VTE. Adjusting for hepcidin and FtL increased rather than reduced the risk estimates for VTE by RDW, suggesting that these parameters may, at least partly, reflect different pathways in VTE development.…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Plasma hepcidin is associated with future risk of venous thromboembolism

et al. 2018

Self Cite

View full text Add to dashboard Cite

Key Points• Iron deficiency may explain the association between RDW and risk of VTE.• Contrary to the hypothesis, increasing plasma levels of hepcidin, a biomarker of iron stores, were associated with increased risk of VTE.Red cell distribution width (RDW) is associated with venous thromboembolism (VTE), but the underlying mechanism(s) is unclear. Iron deficiency is associated with high RDW, and studies suggest an association between iron deficiency and VTE. To assess whether iron deficiency is a risk factor for VTE that explains the association between RDW and VTE, we conducted a nested case-control study of 390 patients with VTE and 802 age-and sex-matched controls selected from the population-based cohort of the Tromsø Study. Physical measurements and blood samples were collected from 1994 to 1995. Logistic regression models were used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) for VTE by RDW, hepcidin, and ferritin light chain (FtL). RDW was inversely associated with hepcidin, FtL, and hemoglobin. The risk of VTE increased linearly across categories of higher plasma hepcidin levels. Participants with hepcidin in the highest quartile had an OR for VTE of 1.32 (95% CI, 1.00-2.42), and those in the .90% percentile had an OR for VTE of 1.66 (95% CI, 1.14-2.42) compared with the reference group (quartiles 2 and 3).The risk estimates remained similar after adjustment for C-reactive protein. The risk of VTE increased by categories of higher RDW and was strengthened after inclusion of hepcidin and FtL in the multivariable model. Our findings reject the hypothesis that iron deficiency explains the association between RDW and VTE and suggest, in contrast, that high body iron levels might increase the risk of VTE.

show abstract

Section: Discussionsupporting

confidence: 93%

“…Red cell distribution width (RDW) has in recent years been associated with several diseases, 14 including VTE, [15][16][17] but the underlying mechanisms remain unknown. RDW is traditionally used in a classification system for anemia, 18 and iron deficiency anemia is strongly associated with high RDW.…”

Section: Introductionmentioning

confidence: 99%

Plasma hepcidin is associated with future risk of venous thromboembolism

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…The baseline RDW and increase in RDW during hospitalization are also compared in patients with sepsis and heart failure (16,17). It is reported that there is an increase in RDW from baseline during the first 72 hours after hospitalization and it is significantly associated with adverse clinical outcomes in sepsis.…”

Section: Discussionmentioning

confidence: 99%

“…It is reported that there is an increase in RDW from baseline during the first 72 hours after hospitalization and it is significantly associated with adverse clinical outcomes in sepsis. Therefore, it is suggested that a combination of baseline RDW value and an increase in RDW can be a promising independent prognostic marker in patients with severe sepsis or septic shock (17). It is also suggested that both initial RDW and change of RDW during hospitalization may be helpful in personalizing prognosis and treatment in patients with heart failure (16).…”

Section: Discussionmentioning

confidence: 99%

Serum RDW Level of COPD Patients and the Characteristics of the Exacerbation

Baris¹,

Önyılmaz²,

Ucar³

et al. 2016

West Indian Med J

View full text Add to dashboard Cite

show abstract

“…Uhm et al [30] from Korea performed to compare clinical and imaging parameters and prognosis of provoked and unprovoked acute PE patients and they found that provoked PE with irreversible risk factors has a poor prognosis for all-cause mortality and recurrent PE than unprovoked PE and provoked PE with reversible risk factors. Ellingsen et al [31] suggested that high RDW is a risk factor of incident VTE, and that RDW is a predictor of all-cause mortality in VTE patients. All of these studies show that VTE treatment needs to be rearranged according to associated risk factors.…”

Section: Discussionmentioning

confidence: 99%

Red Cell Distribution Width Has a Predictable Value for Differentiation of Provoked and Unprovoked Venous Thromboembolism

Ertop

Bilici

Engın

et al. 2015

Indian J Hematol Blood Transfus

View full text Add to dashboard Cite

Venous thromboembolism (VTE) is generally classified as provoked or unprovoked. This dichotomy is important for following patients, mortality rate, prognosis and whether more efficient therapy is needed. In VTE patients, during initial diagnosis, it is not known exactly whether red cell distribution width (RDW) have a predictable value for this differentiation and pathogenesis. In this study, 298 patients with VTE and 197 control subjects were included. Patients with VTE were defined as provoked or unprovoked with respect to physical examination findings and laboratory values. Changes in RDW were tested between VTE patients and control subjects, provoked and unprovoked VTE patients, and separately with control subjects. RDW was found to be high in provoked and unprovoked groups compared with control group (p \ 0.001, p = 0.003 respectively). RDW was significantly high in provoked VTE patients group compared with unprovoked patients (p \ 0.001) and a cut-off value was found to be 13.6 %. In ROC analysis, sensitivity was 90.19 % and specificity was 82 % (95 % CI 85. . RDW could be used as a simple, costeffective and a reliable test independent of age in differentiation of provoked and unprovoked VTE. In order to better understand its role, prospective large homogenized population studies in different regions are necessary.

show abstract

Red cell distribution width is associated with incident venous thromboembolism (VTE) and case-fatality after VTE in a general population

Cited by 30 publications

References 40 publications

Plasma hepcidin is associated with future risk of venous thromboembolism

Plasma hepcidin is associated with future risk of venous thromboembolism

Serum RDW Level of COPD Patients and the Characteristics of the Exacerbation

Red Cell Distribution Width Has a Predictable Value for Differentiation of Provoked and Unprovoked Venous Thromboembolism

Contact Info

Product

Resources

About