Red cell distribution width in type 2 diabetic patients

Nada, Aml Mohamed

doi:10.2147/dmso.s85318

Cited by 72 publications

(89 citation statements)

References 41 publications

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“…MPV, PDW, or PCT values were not different between groups, similar to Nada [21]'s study, which observed that diabetic patients receiving aspirin or clopidogrel did not show significant differences in MPV when compared with controls [19]. Hyperglycaemia may decrease the effectiveness of antiplatelet therapy by increasing reactive oxidant species and lead to aspirin resistance by binding to thromboxane receptors, whereas hypercholesterolaemia may blunt aspirin's effect on thrombin [23,24].…”

Section: Discussionsupporting

confidence: 81%

“…Aspirin's effect on platelet aggregation is subject to inter-individual and intra-individual variability, which can be attributed to multifactorial reasons [20][21][22]. MPV, PDW, or PCT values were not different between groups, similar to Nada [21]'s study, which observed that diabetic patients receiving aspirin or clopidogrel did not show significant differences in MPV when compared with controls [19].…”

Section: Discussionmentioning

confidence: 51%

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Red cell distribution width, other hematological parameters and atherogenic index of plasma in patients with clopidogrel and aspirin resistance

et al. 2016

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Objectives. Chronic inflammation might favour platelet hyperactivity, which leads to inter-individual variability in antiplatelet resistance. The aim of this study was to test the hypothesis that there is a relationship between some hematological parameters reported as measures of systemic inflammation, the atherogenic index of plasma (AIP), and antiplatelet responsiveness. Methods. This retrospective study included patients receiving aspirin (100 mg) and clopidogrel (75 mg) daily before and after stenting. Platelet inhibition was assessed using the VerifyNow P2Y12 point-of-care test. Resistance to antiplatelet therapy was defined as P2Y12 reactivity exceeding 240 units (for clopidogrel) or aspirin reaction units exceeding 550 units (for aspirin). The AIP was calculated as the logarithm of triglyceride/high density lipoprotein cholesterol. The white blood cell (WBC), platelet (P), neutrophil (N), and lymphocyte (L) counts, red cell distribution width (RDW), hemoglobin (Hb), plateletcrit, mean platelet volume (MPV), platelet distribution width, and N/L and P/L ratios were evaluated. Results. Of 232 patients (73% male; median age, 63 years; range, 38-87 years), 52 (22%) were aspirin resistant and 82 (35%) were clopidogrel resistant; 7.7% were both aspirin and clopidogrel resistant. Median RDW levels were significantly higher (14.4% [interquartile rate (IQR) 3] vs. 13.9% [IQR 1.3]; p=0.01) and Hb levels significantly lower (12.0±1.6 g/dL vs. 13.2±1.7 g/dL; p<0.001) in the clopidogrel-resistant patients than in the clopidogrel responders. WBC, AIP, MPV, N/L, and P/L ratios were not statistically significant (p>0.05). Multivariate logistic regression showed that Hb (odds ratio [OR]=0.73; 95% confidence interval [CI], 0.60-0.88; p=0.001) and RDW (OR=1.26; 95% CI, 1.02-1.55; p=0.02) were independent predictors of clopidogrel resistance. Conclusions. Both RDW and Hb were independent variables associated with clopidogrel resistance, but antiplatelet resistance cannot be predicted based on other hematological parameters or AIP.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 51%

Red cell distribution width, other hematological parameters and atherogenic index of plasma in patients with clopidogrel and aspirin resistance

et al. 2016

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“…They discovered RDW was returned to normal after plasma glucose levels and metabolic acidosis were controlled. In a similar study conducted in 2015, it was reported that patients with diabetes had distinctively higher values of RDW compared with healthy individuals, and anisocytosis developed due to impaired erythropoiesis, agglutination, or eryth- rocyte degranulation with fragmentation [15]. Conversely, we found no difference in the RDW, MCV, and RDW/MCV values between groups in our study (p<0.05).…”

Section: Discussioncontrasting

confidence: 56%

Evaluation of Erythrocyte and Thrombocyte Parameters in Pediatric Patients with Diabetes Mellitus

Erdoğan¹

2017

Ann Clin Anal Med

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“…According to the available results, we didn't determine a statistically significant correlation between HbA1C and RDW in the control group, case group or in total.But hyperglycemia has several effects on red blood cells (RBC)s, besides formation of HbA1C. It leads to change in erythrocyte structure, hemodynamic parametres, increased osmotic fragility and also reduces RBC life span [20]. In studies made with much more patients, a close relation was found between RDW and HbA1C, the reason that we couldn't find such a relation may be the low number of patients in the groups and more extensive studies with more patients are needed on this subject.…”

Section: Discussionmentioning

confidence: 99%

Correlation between red blood cell distrubition width and glycated hemoglobin in diabetic and nondiabetic patients

Dilara¹,

Hülya²,

Kilinc³

et al. 2016

Russ Open Med J

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Aim -Our aim in this study is evaluating the red blood cell distrubition width (RDW) and glycated hemoglobin (HbA1C) relation in nondiabetic and diabetic people who applied to our hospital and showing the usability in disease follow-up. Material and Methods -Main data of this research is the data of patients (diabetic and nondiabetic) who applied to internal diseases polyclinic between July 1, 2013 and November 31, 2014 and whose RDW, HbA1C, white blood cell, hemoglobin, and hematocrit were controlled. 82 diabetic and 32 nondiabetic patients were included in this study. Results -No statistically significant difference was observed between the diabetic and nondiabetic groups in age, male and female distribution and RDW. No statistically significant correlation was observed between RDW and age and HbA1C in order in the nondiabetic group. While a correlation which is statistically significant and in the same direction was determine between age and RDW among the diabetic group, a statistically significant correlation was not between HbA1C and RDW. Among all cases a correlation which is statistically meaningful and in the same direction was detected between age and RDW. But a statistically significant correlation was not found between HbA1C and RDW among all cases. Conclusion -According to the available results, no statistically significant correlation was determined between HbA1C and RDW in the nondiabetic patients, diabetic group or in total. But in order to provide more clearance, we believe that studies with more patients would be useful.

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Red cell distribution width in type 2 diabetic patients

Cited by 72 publications

References 41 publications

Red cell distribution width, other hematological parameters and atherogenic index of plasma in patients with clopidogrel and aspirin resistance

Red cell distribution width, other hematological parameters and atherogenic index of plasma in patients with clopidogrel and aspirin resistance

Evaluation of Erythrocyte and Thrombocyte Parameters in Pediatric Patients with Diabetes Mellitus

Correlation between red blood cell distrubition width and glycated hemoglobin in diabetic and nondiabetic patients

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