Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population

Lappé, Jason M.; Horne, Benjamin D.; Shah, Svati H.; May, Heidi T.; Muhlestein, Joseph B.; Lappé, Donald; Kfoury, Abdallah G.; Carlquist, John F.; Budge, D.; Alharethi, Rami; Bair, Tami L; Kraus, William E.; Anderson, Jeffrey L.

doi:10.1016/j.cca.2011.07.018

Cited by 169 publications

(147 citation statements)

References 13 publications

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“…Similar to unstable cardiac events, RDW has been shown to have prognostic value also in stable cardiovascular conditions. For example, Lappe et al [2] demonstrated that RDW was associated with mortality in patients with stable CAD. Increased RDW levels have been demonstrated to have prognostic implication not only in cardiac conditions, but also in many non-cardiac events even in healthy and elderly populations [17].…”

Section: Discussionmentioning

confidence: 99%

“…Like in the case when a car which gets out of control may cause undesirable conditions, over increased inflammation and oxidative stress in our body leads to undesirable outcomes. As a result of changes, they exerted on erythrocytes; increased inflammation [2,3], oxidative stress [5] and neurohormonal activation [18] lead to different size of erythrocytes to involve in the circulation, namely anisocytosis. Possible contribution of inflammation to anisocytosis results from inhibition of the response production against erythropoietin, impaired iron metabolism, and shortened time of red blood cell survival [19].…”

Section: Discussionmentioning

confidence: 99%

“…RDW which is a measure of the variation in the size of circulating erythrocytes (anisocytosis) has been utilized in differential diagnosis of anemia [1]. In addition, increased levels of RDW are closely associated with inflammation [2][3][4], oxidative stress [5] and are related with poor prognoses in stable and unstable cardiac events [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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The impact of admission red cell distribution width on long-term cardiovascular events after primary percutaneous intervention: A four-year prospective study

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The impact of admission red cell distribution width on long-term cardiovascular events after primary percutaneous intervention: A four-year prospective study

et al. 2016

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“…Many studies have reported that the increased levels of RDW are closely associated with inflammation [24][25][26][27] and oxidative stress [28]. All recent data have shown a strong and independent association between RDW and cardiovascular, brain vascular and peripheral artery diseases.…”

Section: Introductionmentioning

confidence: 99%

Medical significance of simultaneous application of red blood cell distribution width (RDW) and neopterin as diagnostic/prognostic biomarkers in clinical practice

Zvetkova

Fuchs²

2017

Pteridines

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In our individual and collaborative studies, we have played a part in pioneering investigations on the usefulness of biomarkers -red blood cell distribution width (RDW) and neopterin. This mini review includes historical data on the topic and is related to the first contributions in this field, as well as to the possibilities for further improvement and simultaneous application of RDW and neopterin measurements in the prevention, prognosis and treatment of a great number of socially important disease conditions (arterial, cardiovascular, brain vascular, peripheral artery diseases, inflammations, autoimmune states, cancers and leukemias, addictions, etc.). When comparing the results obtained with the immunobiochemical biomarker neopterin with RDW, they are reported to be very similar as independent predictors of the same pathological states in the human body although their biomedical origins are very different. Both the parameters were until now successfully, but only separately used in medical practice. The combined use of these two biomarkers can shed some more light on their interrelationships and provide some clues as to how the interaction between immune system activation and red blood cells biology are intertwined.

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“…RDW is widely available, inexpensive and included in blood panel. Studies have been reported that the elevated RDW levels are associated with poor prognosis in the setting of stable angina (1,2), acute myocardial infarction (3,4), heart failure (5, 6), stroke (7), peripheral arterial disease (8), older age (9) and in the patient without coronary artery disease (10,11). One study demonstrated that high RDW values are associated with an increased risk of all-cause mortality in the intensive care unit (12).…”

Section: Introductionmentioning

confidence: 99%

Interrelation of RDW and coronary flow reserve in patient with idiopathic dilated cardiomyopathy

Özülkü¹,

Çalışkan²,

Güllü³

et al. 2014

Anadolu Kardiyol Derg

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Objective: Idiopathic dilated cardiomyopathy (IDC) impairs and reduces coronary flow reserve (CFR). High level of red cell distribution width (RDW) is an independent risk factor for cardiovascular diseases. Therefore, in this observational case-control study we have aimed to determine whether RDW level is associated with CFR impairment in patients with IDC. Methods: We examined 36 patients with IDC and 35 healthy subjects formed as a control group. In addition to this, patients with IDC were divided into two subgroups according to their CFR levels [normal CFR group (CFR value ≥2) and lower CFR group (CFR value<2)]. Control and patients groups were compared using the student t-test for multiple comparisons. The subgroups were compared using the Mann-Whitney U test for continuous variables and chi-square for categorical variables. The Pearson's and Spearman correlation analysis was used to test the possible associations between CFR and the study variables as appropriate. The receiver-operating characteristic (ROC) curve was determined to evaluate the predictive performance of RDW to detect low CFR. Results: There were no significantly differences between the lower and higher CFR groups' clinical data, baseline hemodynamic, medication and biochemical data except RDW and high-sensitivity C-reactive protein levels. We found that RDW level was a good predictor of low CFR at the receiver-operating characteristic curve. The area under the curve (AUC) was 73% (95% confidence interval between 0.56-0.90 is 95%, p: 0.018) After adjusting potential confounders include age, body-mass index, blood pressure, lipid and glucose, RDW independently associated with CFR level (Beta:-0.374; p=0.015) and hsCRP value (Beta:-0.520; p=0.001) were the independent predictors of lower CFR. Conclusion: Results showed that there was an independent correlation between RDW level and CFR level in patients with IDC.

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Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population

Cited by 169 publications

References 13 publications

The impact of admission red cell distribution width on long-term cardiovascular events after primary percutaneous intervention: A four-year prospective study

The impact of admission red cell distribution width on long-term cardiovascular events after primary percutaneous intervention: A four-year prospective study

Medical significance of simultaneous application of red blood cell distribution width (RDW) and neopterin as diagnostic/prognostic biomarkers in clinical practice

Interrelation of RDW and coronary flow reserve in patient with idiopathic dilated cardiomyopathy

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