Red cell distribution width as a potential index to assess the severity of hepatitis <scp>B</scp> virus‐related liver diseases

Huang, Rui; Yang, Chenchen; Wu, Kangkang; Cao, Shufeng; Liu, Yong; Su, Ran; Xiong, Ye; Huang, Aijun; Wu, Chao

doi:10.1111/hepr.12342

Cited by 36 publications

(25 citation statements)

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“…The RDW has been shown to be an independent marker of mortality in multiple cardiovascular diseases and interventions (such as percutaneous coronary interventions), renal, and infectious disease [1][2][3][4]. Recent studies show that RDW values are significantly increased in hepatitis B patients and RDW is an independent 3-month mortality risk predictor in this population [5][6][7]. Other studies have shown that the RDWto-platelet ratio (RPR) can be a predictor of significant fibrosis and cirrhosis in patients with chronic hepatitis B, and it was hypothesized that the high RDW due to anemia and the low platelet count due to cirrhosis may explain this finding [8].…”

Section: Introductionmentioning

confidence: 99%

Red cell distribution width to platelet ratio, a useful indicator of liver fibrosis in chronic hepatitis patients

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Red cell distribution width to platelet ratio, a useful indicator of liver fibrosis in chronic hepatitis patients

et al. 2015

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“…Recently, markers obtained from or calculated using CBC indices, including RDW and/or RPR, were also considered as independent risk factors for studying liver diseases such as HBV-related diseases [8, 10, 15–17], PBC [11], and NAFLD [18]. However, only a few studies in the literature have investigated the relationship between RDW, RPR, and PLR and hepatitis C.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, they indicated that RDW was associated with the severity of hepatitis B in patients and could independently predict a 3-month mortality rate [8]. Huang et al found that the RDW values in patients with HBV-related liver disease were significantly higher than in healthy individuals and considered that RDW could be an independent risk factor for estimating the disease severity [17]. The RPR could also be used as an indicator predicting the presence of significant fibrosis and cirrhosis in chronic HBV patients [15].…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Inflammatory Marker Levels and Hepatitis C Virus Severity

Qin

et al. 2016

Gastroenterology Research and Practice

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Background. Red cell distribution width (RDW) and platelet-lymphocyte ratio (PLR) have been studied in a variety of etiological diseases. We aim to investigate the relationship between RDW and PLR and the severity of hepatitis C virus- (HCV-) related liver disease. Methods. We included fifty-two chronic HCV and 42 HCV-related cirrhosis patients and 84 healthy controls. Hematological and virological parameters and liver function biomarkers of HCV-related patients at admission were recorded. Results. RDW, RDW-to-platelet (RPR), and 1/PLR values in HCV-related cirrhosis patients were significantly higher than in chronic HCV patients and healthy controls (all P < 0.001). The aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AAR), AST-to-platelet ratio index (APRI), and fibrosis index based on the four factors (FIB-4) scores in HCV-related cirrhosis patients were significantly higher than in chronic HCV patients (all P < 0.001). The areas under the curve of the RDW, RPR, and 1/PLR for predicting cirrhosis were 0.791, 0.960, and 0.713, respectively. Bivariate logistic regression analysis showed that RDW could independently predict the presence of cirrhosis in chronic HCV patients. Conclusions. RDW, RPR, and PLR may be potential markers for estimating HCV severity.

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“…15 Huang dkk. 16 menyatakan bahwa red cell distribution width (RDW) meningkat pada hepatitis B kronik dan berpotensi sebagai salah satu indeks keparahan penyakit hepatitis B kronik. Untuk membuat model prediksi baru dengan komponen jumlah trombosit dan red cell distribution width (RDW), Chen dkk.…”

Section: Pembahasanunclassified

“…Rasio RDW/trombosit dalam penelitian ini memiliki kemampuan sedang untuk memprediksi derajat fibrosis (p=0,029 dengan AUC>70%). 16 Hasil penelitian ini memiliki tingkat akurasi sedang (AUC >70-80%), lebih rendah dibanding dengan penelitian dilakukan sebelumnya yang tingkat akurasinya adalah baik (AUC >80-90%). 9 Jumlah sampel merupakan kelemahan penelitian ini sehingga diperlukan penelitian lebih lanjut dengan skala yang lebih besar.…”

Section: Pembahasanunclassified

Akurasi Diagnostik Fibrosis Hati berdasarkan <i>Rasio Red Cell Distribution Width</i> (RDW) dan Jumlah Trombosit Dibanding dengan <i>Fibroscan</i> pada Penderita Hepatitis B Kronik

Jones

Sembiring

Zain

2016

GMHC

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AbstrakHepatitis B kronik merupakan masalah global dan Indonesia termasuk negara yang memiliki prevalensi tinggi. Keterbatasan biopsi hati untuk mendiagnosis fibrosis hati karena invasif membangkitkan penelitian metode noninvasif. Dilakukan penelitian uji diagnostik potong lintang untuk mengetahui akurasi rasio red cell distribution width (RDW) terhadap jumlah trombosit untuk memprediksi derajat fibrosis hati penderita hepatitis B kronik. Terhadap subjek penelitian dilakukan pemeriksaan HBsAg, darah rutin, dan fibroscan di RSUP H. Adam Malik, Medan sejak Januari sampai Maret 2015. Nilai rasio RDW terhadap trombosit dihitung dari hasil pemeriksaan darah rutin. Derajat fibrosis hati dinilai berdasarkan hasil fibroscan dari skala F0-F4. Prosedur analisis adalah receiver operating characteritic (ROC) dan area under the curve (AUC). Dari 34 kasus, 20 orang termasuk kelompok fibrosis hati ringan-sedang (F≤2) dan 14 orang kelompok fibrosis berat (F>2). Nilai akurasi sebesar 72,3% (IK 95%:84,1-97%). Dengan nilai cut-off 0,0591 didapatkan sensitivitas 71,4%; spesifisitas 60%; nilai prediksi positif (NPP) 55,6%; nilai prediksi negatif (NPN) 75%; rasio kemungkinan positif (RKP) 1,79; dan rasio kemungkinan negatif (RKN) 0,48. Simpulan, rasio RDW terhadap jumlah trombosit mampu memprediksi derajat fibrosis hati penderita hepatitis B kronik dengan tingkat akurasi sedang (72,3%). Kata kunci: Fibroscan, fibrosis hati, hepatitis B kronik, RDW, trombosit Diagnostic Accuracy of Liver Fibrosis based on Red Cell Distribution Width (RDW) to Platelet Count with Fibroscan in Chronic B Hepatitis AbstractChronic hepatitis B is a global problem and Indonesia has a high prevalence. Limitation of liver biopsy as an invasive method, initiates many studies on non invasive diagnosing method for liver fibrosis. The cross sectional study was conducted to determine the accuracy of red cell distribution width (RDW) to platelet count ratio (RPR) in predicting liver fibrosis degree in chronic hepatitis B. HBsAg, complete blood count, and fibroscan were examined in H. Adam Malik Hospital, Medan from January to March, 2015. RPR was calculated. The degree of liver fibrosis assessed by fibroscan on a scale of F0-F4. The accuracy was evaluated by constructing receiver operating characteritic (ROC) and area under the curve (AUC). From 34 cases, 20 subjects were in mild-moderate liver fibrosis (F≤2) and 14 subjects in severe liver fibrosis (F>2). The accuracy was 72.3% (95% CI: 84.1-97%) with a cut-off value 0.0591. Sensitivity was 71.4%, specificity 60%, positive predictive value (PPV) 55.6%, negative predictive value (NPV) 75%, positive predictive ratio (PPR) 1.79, and negative predictive ratio (NPR) was 0.48. RDW to platelet count ratio can predict liver fibrosis grade in chronic hepatitis B with a moderate degree of accuracy (72.3%).

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Red cell distribution width as a potential index to assess the severity of hepatitis B virus‐related liver diseases

Abstract: The RDW was elevated in CHB patients and patients with HBV-related liver cirrhosis and was positively correlated with the severity of HBV-related liver cirrhosis. RDW is a potential index to assess the severity of HBV-related liver diseases.

Cited by 36 publications

References 30 publications

Red cell distribution width to platelet ratio, a useful indicator of liver fibrosis in chronic hepatitis patients

Red cell distribution width to platelet ratio, a useful indicator of liver fibrosis in chronic hepatitis patients

The Relationship between Inflammatory Marker Levels and Hepatitis C Virus Severity

Akurasi Diagnostik Fibrosis Hati berdasarkan <i>Rasio Red Cell Distribution Width</i> (RDW) dan Jumlah Trombosit Dibanding dengan <i>Fibroscan</i> pada Penderita Hepatitis B Kronik

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