Red cell distribution width and mean platelet volume in rheumatoid arthritis patients: Its association with disease activity

Atwa, Essam; Omar, Hisham; Amin, Asmaa; Hammad, Marwa

doi:10.1016/j.reuma.2021.04.011

Cited by 8 publications

(6 citation statements)

References 29 publications

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“…Red blood cell distribution width (RDW) and mean platelet volume (MPV) in relation to RA disease activity have been studied previously and a significant correlation was found between RA disease activity and RDW. Also, Atwa et al 31 found RDW was better than ESR and CRP in detecting RA disease activity. The lymphocyte‐monocyte ratio (LMR) is a systemic inflammatory marker for prediction of disease development, progress, and survival.…”

Section: Discussionmentioning

confidence: 99%

The assessment of rheumatoid factor levels and hemogram parameters as predictors for rheumatologic disease

Limon

2023

Int J of Rheum Dis

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Aim Many markers are used for clinical diagnosis in rheumatic diseases; rheumatoid factor (RF) is the most frequently used marker. However, RF is not specific to rheumatoid arthritis (RA). RF positivity is widely observed in patients with advanced age, infectious, autoimmune, and lymphoproliferative diseases. In this context, the objective of this study is to investigate the demographic characteristics, frequency of antinuclear antibody (ANA) and anti‐cyclic citrullinated peptide (anti‐CCP) positivity, hemogram parameters and distribution of the diagnoses in RF‐positive patients followed at the rheumatology clinic. Methods The population of this retrospective study consisted of patients above 18 years of age who were referred to have RF positivity by nephelometric method at Kahramanmaraş Necip Fazıl City Hospital Rheumatology Clinic between January 2020 and June 2022. Results The mean age of the 230 patients with a positive RF test result, 155 (76%) male and 55 (24%) female, was 52.7 ± 15.5 years. There were 81 (35.2%), 54 (23.5%), 73 (31.7%) and 22 (9.6%) patients with RF levels between 20 and 50 IU/mL, 50 and 100 IU/mL, 100 and 500 IU/mL, and above 500 IU/mL, respectively. There was no significant difference detected between the groups that were created based on the RF titers regarding demographic characteristics (P > 0.05). The rate of being diagnosed with any rheumatic disease was significantly lower in the group with RF levels between 20 and 50 IU/mL compared to other groups (P = 0.001). The distribution of rheumatic and non‐rheumatic disease diagnoses according to RF levels did not reveal any significant difference between the groups (P = 0.369 and P = 0.147, respectively). RA was the most common (62.2%) rheumatic disease diagnosis among the patients included in the study. The leukocyte count was significantly higher in the group with RF levels above 500 IU/mL compared to the group with RF levels between 20 and 50 IU/mL (P = 0.024). There was no significant difference between the groups in other laboratory results, that is, hemogram, sedimentation, C‐reactive protein, platelet, and lymphocyte/monocyte ratio (P > 0.05). Conclusion The study findings indicate that RF positivity can be seen in the context of different rheumatological diseases; hence RF levels alone may not predict rheumatological disease. There was also no significant relationship between RF levels and ANA and anti‐CCP positivity. The most common diagnosis in patients presenting with elevated RF levels was RA. Nevertheless, it should be noted that RF can be found asymptomatically in the general population.

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Section: Discussionmentioning

confidence: 99%

The assessment of rheumatoid factor levels and hemogram parameters as predictors for rheumatologic disease

Limon

2023

Int J of Rheum Dis

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“…Previous studies have demonstrated a correlation between RDW and inflammatory markers, including C-reactive protein, erythrocyte sedimentation rate and interleukin-6, suggesting that RDW may serve as a new marker of inflammation. [33][34][35][36] It has been increasingly recognized that inflamma-…”

Section: Discussionmentioning

confidence: 99%

“…Although RDW has been established as an effective predictor of in‐hospital mortality in VAP, the underlying mechanisms responsible for this association remains unclear. Previous studies have demonstrated a correlation between RDW and inflammatory markers, including C‐reactive protein, erythrocyte sedimentation rate and interleukin‐6, suggesting that RDW may serve as a new marker of inflammation 33–36 . It has been increasingly recognized that inflammation can disrupt iron metabolism, impair erythropoietin (EPO) production, and hinder RBC maturation, resulting in elevated RDW values 11 .…”

Section: Discussionmentioning

confidence: 99%

Association of mean RDW values and changes in RDW with in‐hospital mortality in ventilator‐associated pneumonia (VAP): Evidence from MIMIC‐IV database

Nan,

Li,

Wan

et al. 2023

Int J Lab Hematology

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IntroductionVentilator‐associated pneumonia (VAP) is a hospital‐acquired infection with high mortality, and remains a challenge for clinical treatment. Red blood cell distribution width (RDW) was associated with worse outcomes in several diseases. The purpose of this study was to investigate the relationship between mean RDW values, changes in RDW (delta RDW), and in‐hospital mortality among patients with VAP.MethodsIn the present study, we enrolled 1266 VAP patients from the Medical Information Mart for Intensive Care IV (MIMIC‐IV) database. All patients were categorized into low group, medium group, and high group according to tertiles of mean RDW values. The primary outcome was all‐cause in‐hospital mortality. Univariate logistic regression analysis, multivariate logistic regression analysis, and restricted cubic spline (RCS) curve were performed to determine the association between mean RDW values and in‐hospital mortality in VAP. Moreover, RCS curve was plotted to explore the dose–response relationship between delta RDW and in‐hospital mortality in VAP.ResultsAmong the VAP patients included in the study, the in‐hospital mortality was 20.85% with 264 non‐survivors and 1002 survivors. The non‐survivors exhibited significantly higher mean RDW values and delta RDW values compared to survivors. Multivariate logistic regression analysis indicated that mean RDW values were positively associated with in‐hospital mortality in VAP after adjusting for relevant covariates. The RCS curve demonstrated a dose–response relationship between mean RDW and the mortality in VAP. Moreover, a linear relationship was observed between delta RDW and in‐hospital mortality in VAP.ConclusionHigher mean RDW values were significantly associated with an increased risk of in‐hospital mortality in VAP. Additionally, a linear relationship was found between delta RDW values and in‐hospital mortality. These findings suggest that RDW can be used to identify high‐risk patients with poorer outcomes in VAP.

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“…RDW alone was strongly correlated with SLE activity. Furthermore, RDW outperformed CRP and ESR (erythrocyte sedimentation rate) for the activity detection for RA disease (Atwa et al, 2022). Independent of the types of IBS, RDW, and MPV were increased in patients with IBS.…”

Section: The Application Of Rdw In the Diagnosis Of Nonanemic Diseasesmentioning

confidence: 99%

Promising applications of red cell distribution width in diagnosis and prognosis of diseases with or without disordered iron metabolism

Yang

Wang

Gao

et al. 2023

Cell Biology International

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Many indicators, including red cell distribution width (RDW) and iron metabolism, are sensitive to a variety of risk factors, and are associated with the pathological alterations and disease onset. RDW reflects the degree of heterogeneous volumes of peripheral red blood cells (RBCs). It has been well‐known that increased RDW indicates iron deficiency anemia, hemolytic anemia, ineffective erythropoiesis, and shorten lifespan of RBCs. Increased RDW is also prevalent in various non‐anemic pathological conditions and diseases. We here review the factors affecting RDW, particularly disordered iron metabolism, chronic inflammation, and oxidative stress, and recapitulate the interplays among these factors. Furthermore, we review the application of increased RDW together with disordered iron homeostasis and the deregulations of hepcidin expression and ferritin levels in the diagnoses and prognosis of anemic and nonanemic diseases. RDW is inexpensive and readily available and may be valuable in adding to the diagnosis and monitoring of many pathological conditions. RDW combined with other indicators, for example, hepcidin and ferritin levels, should be utilized more frequently in clinical practice.

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Red cell distribution width and mean platelet volume in rheumatoid arthritis patients: Its association with disease activity

Cited by 8 publications

References 29 publications

The assessment of rheumatoid factor levels and hemogram parameters as predictors for rheumatologic disease

The assessment of rheumatoid factor levels and hemogram parameters as predictors for rheumatologic disease

Association of mean RDW values and changes in RDW with in‐hospital mortality in ventilator‐associated pneumonia (VAP): Evidence from MIMIC‐IV database

Promising applications of red cell distribution width in diagnosis and prognosis of diseases with or without disordered iron metabolism

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