Promising applications of red cell distribution width in diagnosis and prognosis of diseases with or without disordered iron metabolism

Yang, Yashuang; Wang, Quanshu; Gao, Ling; Liu, Sijin; Zhao, Jiajun; Liu, Guoliang; Zhang, Shuping

doi:10.1002/cbin.12029

Cited by 3 publications

(2 citation statements)

References 76 publications

(119 reference statements)

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“…6,7 Numerous studies have demonstrated that RDW is associated with aging, inflammation, oxidative stress, nutritional deficiency, erythropoiesis impairment, and telomere shortening. [8][9][10][11] To date, increasing evidence has shown that RDW is associated with worse outcomes in many diseases, including acute exacerbation of chronic obstructive pulmonary disease, COVID-19, multiple myeloma, heart failure, spontaneous intracerebral hemorrhage, and community-acquired pneumonia. [12][13][14][15][16][17] Recently, Deniz et al 18 revealed the significant predictive value of RDW in mortality among ICU patients.…”

Section: Introductionmentioning

confidence: 99%

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Association of mean RDW values and changes in RDW with in‐hospital mortality in ventilator‐associated pneumonia (VAP): Evidence from MIMIC‐IV database

Nan,

Li,

Wan

et al. 2023

Int J Lab Hematology

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IntroductionVentilator‐associated pneumonia (VAP) is a hospital‐acquired infection with high mortality, and remains a challenge for clinical treatment. Red blood cell distribution width (RDW) was associated with worse outcomes in several diseases. The purpose of this study was to investigate the relationship between mean RDW values, changes in RDW (delta RDW), and in‐hospital mortality among patients with VAP.MethodsIn the present study, we enrolled 1266 VAP patients from the Medical Information Mart for Intensive Care IV (MIMIC‐IV) database. All patients were categorized into low group, medium group, and high group according to tertiles of mean RDW values. The primary outcome was all‐cause in‐hospital mortality. Univariate logistic regression analysis, multivariate logistic regression analysis, and restricted cubic spline (RCS) curve were performed to determine the association between mean RDW values and in‐hospital mortality in VAP. Moreover, RCS curve was plotted to explore the dose–response relationship between delta RDW and in‐hospital mortality in VAP.ResultsAmong the VAP patients included in the study, the in‐hospital mortality was 20.85% with 264 non‐survivors and 1002 survivors. The non‐survivors exhibited significantly higher mean RDW values and delta RDW values compared to survivors. Multivariate logistic regression analysis indicated that mean RDW values were positively associated with in‐hospital mortality in VAP after adjusting for relevant covariates. The RCS curve demonstrated a dose–response relationship between mean RDW and the mortality in VAP. Moreover, a linear relationship was observed between delta RDW and in‐hospital mortality in VAP.ConclusionHigher mean RDW values were significantly associated with an increased risk of in‐hospital mortality in VAP. Additionally, a linear relationship was found between delta RDW values and in‐hospital mortality. These findings suggest that RDW can be used to identify high‐risk patients with poorer outcomes in VAP.

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Section: Introductionmentioning

confidence: 99%

“…tion can disrupt iron metabolism, impair erythropoietin (EPO) production, and hinder RBC maturation, resulting in elevated RDW values 11. Moreover, oxidative stress and hypoxia have been implicated in abnormal RDW levels.…”

mentioning

confidence: 99%

Association of mean RDW values and changes in RDW with in‐hospital mortality in ventilator‐associated pneumonia (VAP): Evidence from MIMIC‐IV database

Nan,

Li,

Wan

et al. 2023

Int J Lab Hematology

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The association of manganese levels with red cell distribution width: A population-based study

Dai,

Sun,

Lan

et al. 2024

PLoS ONE

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Objectives Experimental and acute exposure studies imply that manganese affects red blood cell production. Nevertheless, the association between environmental exposure and red blood cell distribution width (RDW) has yet to be explored. This research sought to assess the correlation between blood manganese levels and RDW within the general population of the United States. Materials and methods Employing weighted multiple linear regression models, data from the 2011–2018 National Health and Nutrition Examination Survey (NHANES) were utilized to assess the correlation between manganese levels in the blood and RDW. Restricted cubic spline plots and two-piecewise linear regression models were also employed. Result The analysis included a total of 15882 participants in which we determined an independent positive relationship between blood manganese levels and RDW among participants(β = 0.079, P<0.001). Moreover, we identified a J-shaped association between blood manganese levels and RDW in total participants (inflection point for blood manganese: 7.32 ug/L) and distinct subgroups following adjusted covariates. Women exhibited a more pronounced association, even after controlling for adjusted covariates. Conclusions We determined a J-shaped relationship between blood manganese levels and RDW with an inflection point at 7.32 ug/L for blood manganese. Nevertheless, fundamental research and large sample prospective studies are needed to determine the extent to which blood manganese levels correlate with RDW.

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Study on Red Blood Cell Distribution Width in Children with Severe Mycoplasma Pneumoniae Pneumonia

Wu,

Zhang,

Zhang

et al. 2024

Biomark. Med.

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Background: This study aimed to investigate the clinical value of the red blood cell distribution width (RDW) in severe Mycoplasma pneumoniae pneumonia (MPP). Methods: A total of 185 children with diagnosed severe MPP were included. The patients’ case records and laboratory examination data were analyzed retrospectively. The children were grouped into quartiles based on RDW. Results: Univariate analysis revealed that RDW was significantly correlated with the Pediatric Risk of Mortality (PRISM) III score, Sepsis-Related Organ Failure Assessment score, incidence of invasive intubation and 30-day in-hospital mortality. After adjustment for the severity of illness, multivariate analysis revealed that the PRISM III score and RDW were factors independently associated with 30-day in-hospital mortality. Conclusion: This study revealed that RDW could be correlated with the long-term prognosis and severity of severe MPP.

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Promising applications of red cell distribution width in diagnosis and prognosis of diseases with or without disordered iron metabolism

Cited by 3 publications

References 76 publications

Association of mean RDW values and changes in RDW with in‐hospital mortality in ventilator‐associated pneumonia (VAP): Evidence from MIMIC‐IV database

Association of mean RDW values and changes in RDW with in‐hospital mortality in ventilator‐associated pneumonia (VAP): Evidence from MIMIC‐IV database

The association of manganese levels with red cell distribution width: A population-based study

Study on Red Blood Cell Distribution Width in Children with Severe Mycoplasma Pneumoniae Pneumonia

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