Red Cell Deformability in Gestational Hypertension

Heilmann, L.; Hojnacki, B.; Tempelhoff, G.-F. von

doi:10.1159/000292547

Cited by 7 publications

(2 citation statements)

References 9 publications

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“…6]: 4 of 14 female patients]. Furthermore, rheologic studies [7]in pregnant women showed reduced erythrocyte deformability, which may worsen preeclampsia and preexisting diabetic retinopathy.…”

Section: Commentmentioning

confidence: 99%

Single Isolated Cotton-Wool Spots

Remky¹,

Arend²

2000

Ophthalmologica

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The presence of isolated cotton-wool spots in normal fundi may indicate serious systemic disease. In this presentation 4 patients were examined for blurred vision or scotomas with sudden onset. Two of them were pregnant. Funduscopic examination revealed soft-appearing white spots in the temporal arcades in 3 patients and in the papillomacular bundle in 1 patient. Due to the lack of other fundus lesions 3 of the patients were initially treated for toxoplasmosis. The patients were seronegative for typical viral (HIV), antinuclear antibodies, bacterial infections, or toxoplasmosis. Blood pressures, glycosylated hemoglobin and blood counts were in the normal range. At the follow-up examinations subjective symptoms had improved and the spots disappeared or were smaller and showed more distinct borders, and no new lesions were detected. These cases suggest that isolated cotton-wool spots may occur without serious systemic disease in otherwise healthy subjects and the spots may be misinterpreted as acute inflammatory retinochoroidal lesions.

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Section: Commentmentioning

confidence: 99%

Single Isolated Cotton-Wool Spots

Remky¹,

Arend²

2000

Ophthalmologica

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“…Namely, membrane fluidity of erythrocytes is significantly lower in both spontaneously hypertensive rats and patients with essential hypertension, in comparison to normotensive controls (Tsuda et al 1987;Tsuda 2010). It was observed that low erythrocyte membrane fluidity negatively affects erythrocyte deformability/blood viscosity (Cartwright et al 1985;Heilmann et al 1994). Finally, glucocorticoid excess may also disturb hemodynamics in advanced age, by contributing to the development of some MetS symptoms (Yanovski and Cutler 1994;Friedman et al 1996;Anagnostis et al 2009).…”

Section: Altered Hemodynamics In Advanced Agementioning

confidence: 99%

Glucocorticoid excess and disturbed hemodynamics in advanced age: the extent to which soy isoflavones may be beneficial

Ajdžanović¹,

Milošević²,

Spasojević³

2012

gpb

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Abstract. Advanced age is often accompanied by glucocorticoid excess which contributes to the pathogenesis of the metabolic syndrome associated with some hemodynamic disorders. Impaired central regulation of stress hormones secretion and increased glucocorticoids/adrenal androgens ratio trigger hyperglycemia, elevated blood lipids and visceral fat accumulation, associated with hypertension and increased blood viscosity, all of which represent cardiovascular morbidity factors in this age. Finding the adequate therapeutic solutions is set as an imperative in the treatment of listed symptoms. Biologically active soy isoflavones, exhibiting estrogen-and membrane-receptor agonistic/antagonistic activity, and antioxidative and tyrosine kinase/steroidogenic enzyme inhibiting effects, appear as alternative therapeutics for various ageing-related diseases. It has been shown that soy isoflavones reduce some of the listed risk factors, while affecting the hemodynamic group of cardiovascular parameters directly, as well as indirectly via endocrine perturbations. Soy isoflavones may reverse the glucocorticoids/adrenal androgens ratio, lower serum cholesterol, slow the development of atherosclerotic plaque formation, inhibit platelet aggregation, increase cardiac contractility, but they may have diverse effects on blood viscosity and may increase triglyceride levels. Herein, we present the projection of soy isoflavones-based therapy of glucocorticoid excess and disturbed hemodynamics in advanced age, concluding that although promising, it requires the impartial approach and certain precautions.

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