Changes of erythrocyte microrheology during normal pregnancy and after delivery

Lukacín, S; Rychnavský, J.; Mojžiš, Ján; Mirossay, Ladislav; Jurčová, E.; Nicák, A

doi:10.1016/0301-2115(96)02401-3

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…On studying the factors contributing to blood flow in the intervillous space, we found that during the gestation period of greatest fetal growth (from weeks 20 to 30) there is an increase in the rigidity of the maternal erythrocytes [10,21,26,28] (table I), a risk factor contributing to reduced fetal growth, lower birthweight [21] and lower gestational age at birth, probably due to a diminution in maternal-fetal perfusion arising from an J. Perinat. Med.…”

Section: Discussionmentioning

confidence: 98%

The influence of maternal erythrocyte deformability on fetal growth, gestational age and birthweight

Martínez-Morales

Bonillo-Perales²,

Muñóz-Hoyos³

et al. 1999

Journal of Perinatal Medicine

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The increase in blood viscosity during pregnancy reduces maternal-fetal blood flow, which can lead to fetal hypoxia and acidosis. These factors have been related to a reduction in fetal growth and to premature births. We carried out a longitudinal study of 36 normal-term gestations at different stages of the pregnancy. We analyzed the erythocyte deformability, the intraerythocyte viscosity and the plasma viscosity in the mother, as well as the relation of these parameters to fetal growth (biparietral diameter (BPD) and length of the femur), birthweight, gestational age at birth and the Agpar score. The results obtained were as follows: from weeks 25 to 36 of pregnancy (30.9 (SD 2 weeks)) there occurs a significant increase in maternal erythocyte rigidity (p < 0.05) (despite the compensatory decrease in intracellular viscosity). This increase is very significantly related to the fetal biparietral diameter (r = -0.50, p < 0.01), the length of the fetal femur (r = -0.48, p < 0.02), gestational age at birth (r = -0.73, p < 0.0001, birthweight (r = -0.63, p < 0.001) and the Agpar score 5 minutes after birth (r = 0.67, p < 0.001). Our conclusions are that the reduction in erythocyte deformability (which we attribute to alterations in the fluidity or elasticity of its membrane) and the factors that increase the aggregation capacity of the red cells (modulators of blood viscosity and of blood flow in the placental intervillous space) are risk factors for reduced fetal growth, lower birthweight and lower gestational age at birth. By avoiding maternal hematocrit levels higher than 36% we could improve uteroplacental perfusion, fetal growth and perinatal results.

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Section: Discussionmentioning

confidence: 98%

The influence of maternal erythrocyte deformability on fetal growth, gestational age and birthweight

Martínez-Morales

Bonillo-Perales²,

Muñóz-Hoyos³

et al. 1999

Journal of Perinatal Medicine

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“…Erythrocyte membrane deformability progressively decreases during pregnancy and only increases after delivery. Pregnancy-associated hormones have been implicated as the cause for these changes (Lukačín et al, 1996). Steroid hormones are lipophilic, suggesting they intercalate into the bilayer of membranes, potentially altering the fluidity (Whiting et al, 1995;Perez & Wolfe, 1988;Marra et al, 1998) and function of the membrane.…”

Section: Rbc Membranes During Hypercoagulability and Hormonal Changesmentioning

confidence: 99%

“…Blood hemorheology (Mandelli et al, 1984) and erythrocyte membrane deformability (Lukačín et al, 1996) undergo changes during pregnancy. Erythrocyte membrane deformability progressively decreases during pregnancy and only increases after delivery.…”

Section: Rbc Membranes During Hypercoagulability and Hormonal Changesmentioning

confidence: 99%

Erythrocyte–Platelet Interaction in Uncomplicated Pregnancy

Swanepoel

Pretorius

2014

Microsc Microanal

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Maternal and fetal requirements during uncomplicated pregnancy are associated with changes in the hematopoietic system. Platelets and erythrocytes [red blood cells (RBCs)], and especially their membranes, are involved in coagulation, and their interactions may provide reasons for the changed hematopoietic system during uncomplicated pregnancy. We review literature regarding RBC and platelet membrane structure and interactions during hypercoagulability and hormonal changes. We then study interactions between RBCs and platelets in uncomplicated pregnancy, as their interactions may be one of the reasons for increased hypercoagulability during uncomplicated pregnancy. Scanning electron microscopy was used to study whole blood smears from 90 pregnant females in different phases of pregnancy. Pregnancy-specific interaction was seen between RBCs and platelets. Typically, one or more platelets interacted through platelet spreading and pseudopodia formation with a single RBC. However, multiple interactions with RBCs were also shown for a single platelet. Specific RBC-platelet interaction seen during uncomplicated pregnancy may be caused by increased estrogen and/or increased fibrinogen concentrations. This interaction may contribute to the hypercoagulable state associated with healthy and uncomplicated pregnancy and may also play a fundamental role in gestational thrombocytopenia.

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Determination of erythrocyte membrane deformability after exercise by means of the haemolytic action of mercury ions

Marossy

Bohus

et al. 2003

Comparative Clinical Pathology

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Changes of erythrocyte microrheology during normal pregnancy and after delivery

Cited by 3 publications

References 13 publications

The influence of maternal erythrocyte deformability on fetal growth, gestational age and birthweight

The influence of maternal erythrocyte deformability on fetal growth, gestational age and birthweight

Erythrocyte–Platelet Interaction in Uncomplicated Pregnancy

Determination of erythrocyte membrane deformability after exercise by means of the haemolytic action of mercury ions

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