Red blood cell distribution width predicts 1-month complications after percutaneous transluminal angioplasty

Abstract

Summary Background The identification of patients at higher risk of developing percutaneous transluminal angioplasty (PTA)-related complications is pivotal for achieving better clinical outcomes. We carried out a single-center, observational, retrospective study to explore whether in-hospital changes of red blood cell distribution width (RDW) may help predicting early development of PTA-related complications. Methods The study population consisted of all consecutive patients who underwent PTA for severe peripheral artery occlusive disease (PAOD) during a 2-year period. RDW was measured at hospital admission and discharge, and the delta was calculated. Patient follow-up was routinely performed 1-month after hospital discharge, and was based on thoughtful medical assessment and arterial ultrasonography. The control population consisted of 352 ostensibly healthy subjects. Results The final PTA group consisted of 224 patients. Hemoglobin was lower, whilst mean corpuscular volume (MCV) and RDW were higher in PAOD cases than in controls. Overall, 11 PAOD patients (4.9%) developed clinically significant PTA-related complications 1-month after hospital discharge. Patients who developed 1-month PTA-related complications had lower hemoglobin concentration, but higher RDW and delta RDW than those who did not. Patients with delta RDW >1 had 60% higher risk of developing 1-month PTA-related complications and 88% higher risk of developing early reocclusion. Overall, RDW exhibited an area under the curve (AUC) of 0.68 and 0.74 for predicting 1-month PTA-related complications and early reocclusion, respectively. Conclusions The results of this study suggest that RDW may play a role for guiding the clinical decision making of PTA patients immediately after hospital discharge.

Red Blood Cell Distribution Width Predicts Myocardial Infarction and Mortality After Vascular Surgery–A Prospective Cohort Study

“…Recent studies show that high RDW values are associated with all‐cause mortality both in patients with and without known cardiac disease, as well as a greater mortality rate in older individuals in the presence or absence of major age‐associated diseases [4]. Moreover, some reveal that the RDW baseline value is a strong and independent predictor of poor prognostic outcomes following cardiovascular interventions, such as percutaneous coronary intervention [4, 9], carotid endarterectomy [8], or percutaneous transluminal angioplasty [9].…”

New Markers of Platelet Activation and Reactivity and Oxidative Stress Parameters in Patients Undergoing Coronary Artery Bypass Grafting

“…Oxidative stress, inflammation, and thrombosis are mutually involved in the atherosclerosis development, and progression of this features is evident as disease becomes irreversible [1,2]. Oxidative stress and chronic systemic low-level inflammation and neurohumoral activation could cause increase in heterogeneity of erythrocytes in circulation and influence platelet reactivity [3,4]. Previous studies have investigated the relationship between several simple and routine hematological parameters and atherosclerotic plaque gravity and complexity prediction of unwanted acute cardiovascular events, and acute myocardial infarction outcome [3][4][5][6].…”

“…Oxidative stress and chronic systemic low-level inflammation and neurohumoral activation could cause increase in heterogeneity of erythrocytes in circulation and influence platelet reactivity [3,4]. Previous studies have investigated the relationship between several simple and routine hematological parameters and atherosclerotic plaque gravity and complexity prediction of unwanted acute cardiovascular events, and acute myocardial infarction outcome [3][4][5][6]. Decreased platelet (PLT) count connected with increased mean platelet volume (MPV) could predict changes in platelet reactivity and aggregability [6,7].…”