Red and near infrared light-stimulated angiogenesis mediated via Ca2+ influx, VEGF production and NO synthesis in endothelial cells in macrophage or malignant environments

Stepanov, Yurii V.; Golovynska, Iuliia; Golovynskyi, Sergii; Garmanchuk, L. V.; Gorbach, Oleksandr; Stepanova, L.І.; Khranovska, N.; Остапченко, Л. И.; Ohulchanskyy, Tymish Y.; Qu, Junle

doi:10.1016/j.jphotobiol.2022.112388

Cited by 16 publications

(17 citation statements)

References 88 publications

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“…To date, the most discussed photoacceptor is cytochrome c oxidase (CCO) (6,13). CCO absorbs red/NIR light within wavelengths ranging between 600 and 1000 nm, resulting in the activation of metabolic process as well as migration and proliferation of various cell types: neurons (650–660/808 nm at 3–90 J cm −2 (3,4,14), fibroblasts (660 nm at 5 J cm −2 (15), 660 nm at 3–8 J cm −2 (16), 809 nm at 1.96–7.84 J cm −2 (17)), endothelial cells (635 nm at 24 J cm −2 (18), 650 nm at 30 J cm −2 (19), 665 and 675 nm at 10 J cm −2 (20), 808 nm at 60 J cm −2 (21)), stem cells (660 nm (22,23) and 808 nm at 3 J cm −2 (24)), keratinocytes (780 nm at 0.45–0.95 J cm −2 (25)), lymphocytes (660 nm at 0–5.0 J cm −2 (26), 820 nm at 1.2–8.4 J cm −2 (27)), macrophages (650/808 nm at 3–90 J cm −2 (28)), cancer cells (650/808 nm at 3–90 J cm −2 (3,4), 830 nm at 2 J cm −2 (29)), rat pre‐odontoblast cells (980 nm at 0.65–6.5 J cm −2 (30)), rat satellite cells (632.8 nm at 0.18 J cm −2 (31)), myoblast cells (808 nm at 10–70 J cm −2 (32)) and other cells (33–35).…”

Section: Introductionmentioning

confidence: 99%

Comparing the Impact of NIR, Visible and UV Light on ROS Upregulation via Photoacceptors of Mitochondrial Complexes in Normal, Immune and Cancer Cells

Golovynska

Golovynskyi

2022

Photochem & Photobiology

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The effect of UV/visible/NIR light (380/450/530/650/808/ 1064 nm) on ROS generation, mitochondrial activity and viability is experimentally compared in human neuroblastoma cancer cells. The absorption of photons by mitochondrial photoacceptors in Complexes I, III and IV is in detail investigated by sequential blocking with selective pharmaceutical blockers. Complex I absorbs UV/blue light by heme P450, resulting in a very high rate (14 times) of ROS generation leading to cell death. Complex III absorbs green light, by cytochromes b, c1 and c, and possesses less ability for ROS production (seven times), so that only irradiation lower than 10 mW cm À2 causes an increase in cell viability. Complex IV is well-known as the primary photoacceptor for red/NIR light. Light of 650/808 nm at 10-100 mW cm À2 generates a physiological ROS level about 20% of a basal concentration, which enhance mitochondrial activity and cell survival, while 1064 nm light does not show any distinguished effects. Further, ROS generation induced by low-intensity red/NIR light is compared in neurons, immune and cancer cells. Red light seems to more rapidly stimulate ROS production, mitochondrial activity and cell survival than 808 nm. At the same time, different cell lines demonstrate slightly various rates of ROS generation, peculiar to their cellular physiology.

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Section: Introductionmentioning

confidence: 99%

Comparing the Impact of NIR, Visible and UV Light on ROS Upregulation via Photoacceptors of Mitochondrial Complexes in Normal, Immune and Cancer Cells

Golovynska

Golovynskyi

2022

Photochem & Photobiology

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“…Studies have shown that appropriate local photothermal effects can accelerate microcirculatory blood flow, stimulate angiogenesis and thus promote wound healing. 68 As illustrated in Fig. 4a, the temperature of the ZPTA-G/HMA group rose to 48.83 ± 0.84 °C within 30 min under NIR (1.0 W cm −2 ) irradiation, while that of the G/HMA group and PBS group only rose to 32.40 ± 0.98 °C and 28.54 ± 0.55 °C, respectively.…”

Section: Resultsmentioning

confidence: 81%

Dual-light defined in situ oral mucosal lesion therapy through a mode switchable anti-bacterial and anti-inflammatory mucoadhesive hydrogel

Liu

et al. 2023

Biomater. Sci.

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“…Previous studies demonstrated the modulation of M1/M2 polarization of microglia under NIR treatment. [16,[45][46][47] Stepanov et al observed that red/NIR light significantly increased the percentage of M2 macrophages secreting VEGF and promoting endothelial cell proliferation. [45] Leden et al showed that low-energy density 808-nm light altered M1/M2 polarization and reduced the release of pro-inflammatory factors.…”

Section: Discussionmentioning

confidence: 99%

Exosomes Derived from M2 Microglial Cells Modulated by 1070‐nm Light Improve Cognition in an Alzheimer's Disease Mouse Model

Chen,

Bao,

Xing

et al. 2023

Advanced Science

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Near‐infrared photobiomodulation has been identified as a potential strategy for Alzheimer's disease (AD). However, the mechanisms underlying this therapeutic effect remain poorly characterize. Herein, it is illustrate that 1070‐nm light induces the morphological alteration of microglia from an M1 to M2 phenotype that secretes exosomes, which alleviates the β‐amyloid burden to improve cognitive function by ameliorating neuroinflammation and promoting neuronal dendritic spine plasticity. The results show that 4 J cm−2 1070‐nm light at a 10‐Hz frequency prompts microglia with an M1 inflammatory type to switch to an M2 anti‐inflammatory type. This induces secretion of M2 microglial‐derived exosomes containing miR‐7670‐3p, which targets activating transcription factor 6 (ATF6) during endoplasmic reticulum (ER) stress. Moreover, it is found that miR‐7670‐3p reduces ATF6 expression to further ameliorate ER stress, thus attenuating the inflammatory response and protecting dendritic spine integrity of neurons in the cortex and hippocampus of 5xFAD mice, ultimately leading to improvements in cognitive function. This study highlights the critical role of exosomes derive from 1070‐nm light‐modulated microglia in treating AD mice, which may provide a theoretical basis for the treatment of AD with the use of near‐infrared photobiomodulation.

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Red and near infrared light-stimulated angiogenesis mediated via Ca2+ influx, VEGF production and NO synthesis in endothelial cells in macrophage or malignant environments

Cited by 16 publications

References 88 publications

Comparing the Impact of NIR, Visible and UV Light on ROS Upregulation via Photoacceptors of Mitochondrial Complexes in Normal, Immune and Cancer Cells

Comparing the Impact of NIR, Visible and UV Light on ROS Upregulation via Photoacceptors of Mitochondrial Complexes in Normal, Immune and Cancer Cells

Dual-light defined in situ oral mucosal lesion therapy through a mode switchable anti-bacterial and anti-inflammatory mucoadhesive hydrogel

Exosomes Derived from M2 Microglial Cells Modulated by 1070‐nm Light Improve Cognition in an Alzheimer's Disease Mouse Model

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