Dual-light defined <i>in situ</i> oral mucosal lesion therapy through a mode switchable anti-bacterial and anti-inflammatory mucoadhesive hydrogel

Liu, Huijie; Li, Qun; Xu, Yingying; Sun, Yue; Fan, Xin; Fang, Huaqiang; Hu, Binbin; Huang, Li; Lan, Lei; Wang, Xiaolei

doi:10.1039/d2bm01721k

Cited by 8 publications

(4 citation statements)

References 68 publications

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“…(Figure ). With the continuous development and improvement of the functionalization of hydrogels, more and more hydrogels are used in basic and clinical oral research, including periodontal treatment, − surgical treatment (e.g., oral cancer, wound healing after tooth extraction), − mucosal diseases (e.g., oral ulcers, stomatitis), − and dental hard tissue/endodontic diseases (tooth whitening, oral caries, root canal treatment, etc. ). − Next, we will focus on the application of hydrogels in the treatment of several typical dental hard tissue and endodontic diseases, give a detailed analysis, and make a summary.…”

Section: Properties and Applications Of Functional Hydrogelsmentioning

confidence: 99%

Recent Advances in Functional Hydrogels for Treating Dental Hard Tissue and Endodontic Diseases

Li,

Zhang,

Bao

et al. 2024

ACS Nano

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Section: Properties and Applications Of Functional Hydrogelsmentioning

confidence: 99%

Recent Advances in Functional Hydrogels for Treating Dental Hard Tissue and Endodontic Diseases

Li,

Zhang,

Bao

et al. 2024

ACS Nano

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“…Hydrogels can be injected In situ to fill defects, providing the advantages of targeted therapy, less invasiveness, high safety, and easy handling. Hyaluronic acid is a natural component extracted from living organisms and is widely used in biomedicine because of its safety and three-dimensional structure similar to that of biological tissues [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

A ROS-responsive loaded desferoxamine (DFO) hydrogel system for traumatic brain injury therapy

Qiu,

Zeng,

Zhang

et al. 2024

Biomed. Mater.

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Traumatic brain injury (TBI) produces excess iron, and increased iron accumulation in the brain leads to lipid peroxidation and reactive oxygen species (ROS), which can exacerbate secondary damage and lead to disability and death. Therefore, inhibition of iron overload and oxidative stress has a significant role in the treatment of TBI. Functionalized hydrogels with iron overload inhibiting ability and of oxidative stress inhibiting ability will greatly contribute to the repair of TBI. Herein, an injectable, post-traumatic microenvironment-responsive, ROS-responsive hydrogel encapsulated with deferrioxamine mesylate (DFO) was developed. The hydrogel is rapidly formed via dynamic covalent bonding between phenylboronic acid grafted hyaluronic acid (HA-PBA) and polyvinyl alcohol (PVA), and phenylboronate bonds are used to respond to and reduce ROS levels in damaged brain tissue to promote neuronal regeneration and recovery. The release of DFO from HA-PBA/PVA hydrogels in response to ROS further promotes neuronal regeneration and recovery by relieving iron overload and thus eradicating ROS. In the Feeney model of Sprague Dawley (SD) rats, HA-PBA/PVA/DFO hydrogel treatment significantly improved the behavior of TBI rats and reduced the area of brain contusion in rats. In addition, HA-PBA/PVA/DFO hydrogel significantly reduced iron overload to reduce ROS and could effectively promote post-traumatic neuronal recovery. Its effects were also explored, and notably, HA-PBA/PVA/DFO hydrogel can reduce iron overload as well as ROS, thus protecting neurons from death. Thus, this injectable, biocompatible and ROS-responsive drug-loaded hydrogel has great potential for the treatment of TBI. This work suggests a novel method for the treatment of secondary brain injury by inhibiting iron overload and the oxidative stress response after TBI.

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“…Tannic acid (TA) can interact with proteins, causing them to clump and adhere to each other, 41 and it can act as an adhesive agent for the wet oral mucosa, allowing hydrogels containing TA to adhere to the surface of the oral mucosa with greater strength. 42 In addition, TA has anti-inflammatory and astringent effects, shrinking tissues and reducing vascular permeability, which is effective in controlling bleeding and reducing pain. Therefore, TA can aid in reducing the area of impairment and promoting healing during the treatment of oral mucosal impairments.…”

Section: Introductionmentioning

confidence: 99%

Wet adhesive hydrogels based on niobium carbide for experimental research of oral mucosal impairment

Chen,

Ren,

et al. 2024

RSC Adv.

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Dual-light defined in situ oral mucosal lesion therapy through a mode switchable anti-bacterial and anti-inflammatory mucoadhesive hydrogel

Abstract: Oral mucosal ulcer is the most prevalent oral mucosal lesion, affecting the quality of life. Due to the moist and highly dynamic oral lining, the existing oral mucoadhesives are unable...

Cited by 8 publications

References 68 publications

Recent Advances in Functional Hydrogels for Treating Dental Hard Tissue and Endodontic Diseases

Recent Advances in Functional Hydrogels for Treating Dental Hard Tissue and Endodontic Diseases

A ROS-responsive loaded desferoxamine (DFO) hydrogel system for traumatic brain injury therapy

Wet adhesive hydrogels based on niobium carbide for experimental research of oral mucosal impairment

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