Recurring Phyllodes Tumor in Aberrant Breast Tissue of the Vulva

Tbakhi, Abdelghani; Df, Cowan; Kumar, Devesh; Kyle, D. Braden

doi:10.1097/00000478-199309000-00013

Cited by 41 publications

(39 citation statements)

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“…19,20 Giger et al 20 demonstrated strong NY-BR-1 expression by the phyllodes tumor of the vulva with similar strong expression from nearby mammary-like anogenital glands, suggesting that the phyllodes tumor of the vulva likely originate from these glands. The involvement of hormones in the development of phyllodes tumors of the vulva is suggested by reports that correlate the appearance of tumor with the onset of puberty 14 and rapid growth during 17-b-estradiole treatment for menopausal symptoms. 20,21 The presence of similar tumors in prostate and seminal vesicles with a different immunohistochemical pattern suggest alternate mechanisms for these locations.…”

Section: Pathogenesismentioning

confidence: 99%

“…The prognosis of this neoplasm is uncertain, with local recurrence being the most common complication. [12][13][14] However, none of the reports of this entity, to our knowledge, has yet shown evidence of metastatic potential associated with its breast counterpart, despite a case report showing phyllodes tumor of the vulva with histologic features suggestive of malignancy. 15 In this report, we review the literature on clinical and pathologic findings of this rare entity.…”

mentioning

confidence: 98%

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Phyllodes Tumor of Vulva: A Brief Diagnostic Review

Lee

Nodit

2014

Archives of Pathology &Amp; Laboratory Medicine

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Phyllodes tumors of the vulva are rare proliferations that share morphologic similarities with breast neoplasms. Their histogenetic origin is elusive and may be associated with specialized mammary-like glands of the vulva. Because of their rarity, the clinical and pathologic features, classification, and therapy are not well defined, and their biologic behavior is difficult to predict by histology alone. Immunohistochemical expression of estrogen and progesterone receptors and breast markers provide further support for a common origin. Surgical resection is the current mainstay of therapy and is definitive in most cases.

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Section: Pathogenesismentioning

confidence: 99%

mentioning

confidence: 98%

Phyllodes Tumor of Vulva: A Brief Diagnostic Review

Lee

Nodit

2014

Archives of Pathology &Amp; Laboratory Medicine

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“…The most common anatomical sites were the labium majus and minus, but the interlabial sulcus and mons pubis were reported once. They were usually solitary except the case reported by Tbakhi et al (1). All the tumors were microscopically identical to its counterpart in the breast, with a characteristic biphasic phenotype of phyllodes tumor and leaf-like configuration (1-7).…”

Section: Discussionmentioning

confidence: 79%

“…It is also known to occur in various other anatomical sites, including the vulva, prostate and axilla (1)(2)(3)(4)(5)(6)(7)(8)(9). The tumor has epithelial and stromal components.…”

Section: Introductionmentioning

confidence: 99%

Phyllodes tumor of the vulva: report of two cases

Özbudak¹,

Akkaya²,

Akkaya³

et al. 2013

TJPATH

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Ectopic breast tissue can occur anywhere along the primitive embryonic milk line and can be the site of the same pathologic processes found in the normal breast. Phyllodes tumor is an extremely rare fibroepithelial neoplasm that occurs in ectopic breast tissue of the vulva. To date, only 8 cases of phyllodes tumor in the vulva have been reported in the literature. This paper presents two additional case of benign phyllodes tumor in the vulva. The first patient was a 43-year-old woman, presenting with a lesion on the left anterior mons pubis that had increased in size in the last three months. The second patient was a 50-year-old woman, presenting with a two-month history of a mass in the right labium majus. The patients underwent excisional biopsy. The histological examination of both specimens revealed a characteristic pattern of benign phyllodes tumor. In conclusion, the pathologists need to be aware that the lesion can occur in this location. Herein, the concepts about the histogenesis of phyllodes tumor in the vulva are discussed and a brief review of the previously reported cases is given. Key Words: Vulva, Phyllodes tumor ÖZEktopik meme dokusu ilkel embriyonik sütyolu boyunca herhangi bir yerde ortaya çıkabilir ve normal memede izlenebilen aynı patolojik durumlar ektopik meme dokusunda da görülebilir. Fillods tümör vulvadaki ektopik meme dokusunda oluşan nadir bir fibroepitelyal neoplazidir. Literatürde bugüne kadar 8 olgu bildirilmiştir. Bu makalede literatüre ek olarak iki ayrı vulvar fillods tümör vakası sunulmuştur. İlk olgu, sol ön mons pubiste boyutu son üç ayda artış gösteren bir lezyon ile kliniğe başvurmuş 43 yaşında kadın hastadır. İkinci olgu 50 yaşında kadın hasta olup, iki aydır varolan sağ labium majusta kitle ile başvurmuştur. Mevcut lezyonlara eksizyonel biopsi yapılmış ve örneklerin patolojisi benign fillods tümör ile uyumlu rapor edilmiştir. Sonuç olarak, fillods tümörün vulva lokalizasyonunda da karşılaşabilecek bir antite olduğu unutulmamalıdır. Burada, vulvar fillods tümörün histogenezi ile ilgili kavramlar tartışılmış ve olgularımız daha önce bildirilen olgular eşliğinde sunulmuştur.

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“…Since then, only occasional cases have been reported by Tbahkhi et al [3] and Rose et al [4]. Of these, only 9 women were not pregnant or puerperal at the time their lesions were excised [1].…”

Section: Introductionmentioning

confidence: 99%