Phyllodes tumor of the vulva: report of two cases

Abstract

Ectopic breast tissue can occur anywhere along the primitive embryonic milk line and can be the site of the same pathologic processes found in the normal breast. Phyllodes tumor is an extremely rare fibroepithelial neoplasm that occurs in ectopic breast tissue of the vulva. To date, only 8 cases of phyllodes tumor in the vulva have been reported in the literature. This paper presents two additional case of benign phyllodes tumor in the vulva. The first patient was a 43-year-old woman, presenting with a lesion on the left anterior mons pubis that had increased in size in the last three months. The second patient was a 50-year-old woman, presenting with a two-month history of a mass in the right labium majus. The patients underwent excisional biopsy. The histological examination of both specimens revealed a characteristic pattern of benign phyllodes tumor. In conclusion, the pathologists need to be aware that the lesion can occur in this location. Herein, the concepts about the histogenesis of phyllodes tumor in the vulva are discussed and a brief review of the previously reported cases is given. Key Words: Vulva, Phyllodes tumor ÖZEktopik meme dokusu ilkel embriyonik sütyolu boyunca herhangi bir yerde ortaya çıkabilir ve normal memede izlenebilen aynı patolojik durumlar ektopik meme dokusunda da görülebilir. Fillods tümör vulvadaki ektopik meme dokusunda oluşan nadir bir fibroepitelyal neoplazidir. Literatürde bugüne kadar 8 olgu bildirilmiştir. Bu makalede literatüre ek olarak iki ayrı vulvar fillods tümör vakası sunulmuştur. İlk olgu, sol ön mons pubiste boyutu son üç ayda artış gösteren bir lezyon ile kliniğe başvurmuş 43 yaşında kadın hastadır. İkinci olgu 50 yaşında kadın hasta olup, iki aydır varolan sağ labium majusta kitle ile başvurmuştur. Mevcut lezyonlara eksizyonel biopsi yapılmış ve örneklerin patolojisi benign fillods tümör ile uyumlu rapor edilmiştir. Sonuç olarak, fillods tümörün vulva lokalizasyonunda da karşılaşabilecek bir antite olduğu unutulmamalıdır. Burada, vulvar fillods tümörün histogenezi ile ilgili kavramlar tartışılmış ve olgularımız daha önce bildirilen olgular eşliğinde sunulmuştur.

Phyllodes tumour of the labia minora

“…Herein, we present a case of a benign appearing labial cyst which was pathologically determined to be consistent with a rare phyllodes tumour. Seventeen previously reported cases of vulvar phyllodes tumours have been reported in the literature2–12; however, our case represents the first reported tumour located in the labia minora. As these tumours are rarely found in the vulva, treatment and prognosis is less established13; we discuss the differential diagnosis, treatment and surveillance to be considered for these rare tumours.…”

Phyllodes Tumor of the Breast Metastasizing to the Vulva

“…Breast-like tumors of the vulva are rare. About 8 cases only of vulvar phyllodes tumors have been described [ 13 ]. Phyllodes tumors of the breast have been known to metastasize to other distant organs in the body but not to the vulvar area [ 14 ]; this case represents to the best of our knowledge the first reported case of a breast phyllodes tumor metastasizing to the vulvar area.…”

Fibroepithelial tumors of the anogenital mammary-like glands

“…Как и при патологии молочной железы, в аногенитальной области выделяют доброкачественные ЛО, пограничные (low grade) и злокачественные (high grade) [5]. В литературе описано всего 14 случаев доброкачественной ЛО аногенитальной области [46][47][48][49][50][51][52][53][54][55][56]. Подробная клинико-морфологическая характеристика ЛО АМПЖ представлена в таблице.…”

“…При перианальном расположении узла возможно кровотечение из прямой кишки [25]. Описаны единичные случаи множественных ФА [11,13,18,37] и ЛО аногенитальной области [46,47,53]. Хирургическое удаление является радикальным методом лечения в большинстве слу-чаев.…”

“…Клетки эпителиального компонента при иммуногистохимическом исследовании экспрессируют стероидные гормоны (ER, PR, AR), а также GCDFP-15, mammoglobin и маркеры, отражающие иммунофенотип эпителия молочной железы [11,22,26,31,53,55,60].…”