Recurrent Urinary Tract Infections are Associated With Frailty in Older Adults

Tang, M.; Quanstrom, Kathryn; Jin, Chengshi; Suskind, Anne M.

doi:10.1016/j.urology.2018.09.025

Cited by 23 publications

(26 citation statements)

References 11 publications

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“…Because the UCSF‐GUD does not include comorbidity, the number of medications was used as a proxy measurement. Use of number of mediations to this effect is consistent with our prior publications examining frailty in older adults 20,25,26 …”

Section: Methodssupporting

confidence: 83%

“…This is consistent with how we have performed similar analyses in prior studies. 20,25,26 Overall, 377 (78.9%) individuals had a TUGT the same day as their urodynamics testing, 41 (8.6%) had a TUGT taken within a month of urodynamics testing, 23 (4.8%) individuals had a TUGT taken within 2 months of urodynamics testing, 11 (2.3%) had a TUGT taken within 3 months of urodynamics testing, 9 (1.9%) had a TUGT taken within 4 months of urodynamics testing, 6 (1.3%) had a TUGT taken within 5 months of urodynamics testing, 1 (0.2%) had a TUGT taken within 6 months of urodynamics testing, and 10 (2.1%) had a TUGT taken more than 6 months of their urodynamics testing.…”

Section: Covariatesmentioning

confidence: 99%

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The association between frailty and detrusor overactivity in older adults

Song

Jin

Kamal

et al. 2020

Neurourology and Urodynamics

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Objective To explore the relationship between frailty, age, and detrusor overactivity (DO) in older adults presenting to an academic urology practice. Materials and Methods This study uses the University of California, San Francisco Geriatric Urology Database to examine all adults ages ≥65 years who underwent urodynamic testing from December 2015 to April 2019. All subjects had a timed up and go test (TUGT) as a measure of frailty and were categorized as fast (≤10 seconds), intermediate (11‐14 seconds), or slow (≥15 seconds), corresponding to not frail, pre‐frail, and frail, respectively. Urodynamic studies were reviewed for the presence of DO. Univariate and multivariate logistic regression were used to examine the relationship between frailty, age, and the presence of DO. Results In total, 549 older adults underwent urodynamics during the study period, and 48.5% had a study that demonstrated DO. Individuals with DO tended to be older (18.4% vs 11.0% were ≥80 years; P = .01) and more frail (19.5% vs 13.4% with TUGT ≥5 seconds; P < .01). Multivariate regression demonstrated that DO was associated with both pre‐frail and frail TUGT times (adjusted odds ratio [aOR], 2.1; 95% confidence interval [CI], 1.3‐3.4; P < .01 for TUGT 11‐14 seconds, and aOR, 2.1; 95% CI, 1.1‐4.0; P = .02 for TUGT ≥15 seconds). Age was not found to be significantly associated with DO (P's > .05). Conclusions Frailty, not age, is associated with DO among older adults undergoing urodynamics. Further research on the role of frailty in the evaluation and management of older adults with DO is warranted to best serve the needs of this population.

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Section: Methodssupporting

confidence: 83%

Section: Covariatesmentioning

confidence: 99%

The association between frailty and detrusor overactivity in older adults

Song

Jin

Kamal

et al. 2020

Neurourology and Urodynamics

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“…A prospective study by Tang et al (2019) collected data from an institutional review board approved database that includes the Timed Up and Go Test (TUGT) as a measure of frailty for all outpatient visits in their nononcologic urology clinical practice. The aim of the study was to investigate whether there is any association between frailty and recurrent Urinary Tract Infections (UTIs).…”

Section: Association Between Frailty and Urinary Tract Infectionsmentioning

confidence: 99%

“…They concluded that recurrent UTIs are significantly more frequent in frail patients irrespective of their age. Thus, frailty has to be considered as a more important factor in the treatment and follow up of patients with recurrent UTIs than advanced age 14 .…”

Section: Association Between Frailty and Urinary Tract Infectionsmentioning

confidence: 99%

“…The treatment of any anatomical or functional abnormalities that could be associated to UTIs in the frail is also a successful preventive measure if the patients are fit enough to undergo a corrective procedure. For example, a transurethral resection of the prostatic adenoma in males and correction of pelvic organ prolapse in women can prevent recurrent infections in these patients caused from increased post-void residual urine or incontinence 14 .…”

Section: Prevention Of Utis and Frailtymentioning

confidence: 99%

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Frailty associated urinary tract infections (FaUTIs)

Κωστακόπουλος¹,

Karakousis²,

Moschotzopoulos³

2021

JFSF

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Frailty syndrome is an age-related clinical condition in which someone is prone to negative health associated outcomes such as reduction in physical activity, disability and hospitalizations 1. In particular, frail individuals are vulnerable to all these outcomes when exposed to stressors, both endogenous and exogenous 1. These stressors may have different consequences concerning people with frailty to achieve complete recovery of their former health status 1. Nowadays, health care professionals have to deal with increasingly older patients and their decline in functioning among multiple systems of their body 2. Therefore, over the past 20 years, assessment tools and indexes have been developed in order to identify people who are at great risk for adverse health associated outcomes related to frailty 3,4. Moreover, these tools and indexes may allow us to detect frail individuals perioperatively and determine our treatment strategy for frail surgical patients in order to reduce postoperative complications 4,5. Urinary tract infections (UTIs) are infectious diseases which are very common in humans and are caused by bacteria entering urethra, developing in the bladder and spreading to kidneys. They can be located in any part of the urinary tract 6. Apart from uncomplicated UTIs which can resolve either spontaneously or with antibiotics, there are also more complicated forms such us catheter-associated UTI (CaUTI), recurrent UTI (rUTI), male UTIs 7. The accurate diagnosis of these infections and early treatment play a pivotal role due to risk of recurrence, septicaemia and long-term consequences 8. UTIs are a considerable cause of morbidity among elders 9. However, the global antibiotic use for UTIs and their recurrence has led to increased antibiotic resistance making their treatment particularly challenging 10 .

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Prevalence, antibiotic resistance pattern for bacteriuria from patients with urinary tract infections

Hossain,

Azad,

Shahid

et al. 2024

Health Science Reports

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Background and AimsAntibiotic resistance presents a significant global public health challenge, particularly for urinary tract infections (UTIs), and is notably severe in developing countries. Surveillance of the antimicrobial susceptibility patterns of UTI‐causing bacteria is crucial for effective treatment selection. This study aimed to analyze these patterns in bacteria isolated from the urine samples of patients at Mughda Medical College Hospital, Dhaka, Bangladesh.MethodsA retrospective study (January 2019 to December 2020) at Mugdha Medical College and Hospital, Dhaka, examined clinical and laboratory data from patients with positive urine cultures (≥105 CFU/mL). The study classified patients into four age groups: children (1–<18 years), young adults (18–<33 years), middle‐aged adults (33–50 years), and old adults (>50 years). The standard Kirby‐Bauer method was used to assess antibiotic sensitivity to 28 common antibiotics.ResultsAmong 243 positive urine cultures in both community‐ and hospital‐acquired UTIs, Escherichia coli was the most common uropathogen (65.84%), followed by Klebsiella spp. (12.34%), Enterococcus spp. (8.23%), and other types of bacteria.ConclusionOld adults are particularly vulnerable to UTIs, with E. coli being the predominant causative agent in the study region. The observed antimicrobial resistance patterns underscore the necessity of judicious antibiotic selection to effectively treat UTIs across different age groups.

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Recurrent Urinary Tract Infections are Associated With Frailty in Older Adults

Cited by 23 publications

References 11 publications

The association between frailty and detrusor overactivity in older adults

The association between frailty and detrusor overactivity in older adults

Frailty associated urinary tract infections (FaUTIs)

Prevalence, antibiotic resistance pattern for bacteriuria from patients with urinary tract infections

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