Recurrent Subependymoma Treated with Radiosurgery

Ecker, Robert D.; Pollock, Bruce E.

doi:10.1159/000076662

Cited by 15 publications

(7 citation statements)

References 33 publications

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“…In hindsight, the radiation therapy received by our patient was injurious and is no longer part of modern management of subependymoma. In contrast, stereotactic radiosurgery has been used successfully for small diameter subependymoma [3, 7] with no tumour recurrence reported in a case following 54 months of follow-up [3]. Whether this could be considered as an alternative first-line treatment in subependymoma remains to be determined due to the lack of reported cases.…”

Section: Historical Perspectivementioning

confidence: 99%

Surgical management and long-term outcome of intracranial subependymoma

et al. 2018

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BackgroundIntracranial subependymomas account for 0.2–0.7% of central nervous system tumours and are classified as World Health Organization (WHO) grade 1 tumours. They are typically located within the ventricular system and are detected incidentally or with symptoms of hydrocephalus. Due to paucity of studies exploring this tumour type, the objective was to determine the medium- to long-term outcome of intracranial subependymoma treated by surgical resection.MethodsRetrospective case note review of adults with intracranial WHO grade 1 subependymoma diagnosed between 1990 and 2015 at the Walton Centre NHS Foundation Trust was undertaken. Tumour location, extent of resection (defined as gross total resection (GTR), sub-total resection (STR) or biopsy) and the WHO performance status at presentation and through follow-up were recorded.ResultsThirteen patients (7 males; 6 females) with a mean age of 47.6 years (range 33–58 years) and a median follow-up of 46 months (range 25–220 months) were studied. Eight patients had symptomatic tumours (headache, visual disturbance); five had incidental finding. Tumours were most commonly located in the fourth ventricle (n = 8). The performance status scores at diagnosis were 0 (n = 8) and 1 (n = 5). The early post-operative performance status scores at 6 months were 0 (n = 5) and 1 (n = 8) and at last follow-up were 0 (n = 11) and 1 (n = 2). There was no evidence of tumour re-growth following GTR or STR. The commonest complication was hydrocephalus (n = 3).ConclusionSubependymoma are indolent tumours. No patients exhibited a worsening of performance status at medium- to long-term follow-up and there were no tumour recurrence suggesting a shorter follow-up time may be sufficient. Surgical resection is indicated for symptomatic tumours or those without a clear imaging diagnosis. Incidental intraventricular subependymoma can be managed conservatively through MRI surveillance.

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Section: Historical Perspectivementioning

confidence: 99%

Surgical management and long-term outcome of intracranial subependymoma

et al. 2018

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“…Historically, a surgical cure for subependymomas has been achieved with gross total resection, with only a few reports of recurrence (5,7,12). These aggressive subependymomas can show local invasion and metastasis (7).…”

Section: Treatment and Prognosismentioning

confidence: 99%

Subependymomas: An analysis of Clinical and Imaging Features

et al. 2006

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Subependymomas are rare, representing only 0.51% of all central nervous system tumors operated on during an 8-year period at the University of Utah. Clinical symptoms were associated with tumor location: intracranial masses caused headaches, seizures, and neurological complaints, and spinal cord locations resulted in neurological deficit. The authors review the clinical presentation, management, and contemporary radiographic appearance of this rare tumor.

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“…21 Radiation therapy may be applied for the management of partially resected or recurrent tumours, but no consensus has been reached. 7,22 The scarcity of clinical information on subependymoma in a cat makes it difficult to predict postoperative prognosis; however, based on MRI findings, including a well-demarcated contrast-enhanced lesion and its location, extra-axial tumour was suspected, which made this case a candidate for surgical treatment. Although the lesion was thought accessible by dorsal midline approach followed by craniotomy of the caudal occipital bone and partial laminectomy of the atlas, this case was at increased risk of perioperative complications as in any cases with lesions compressing the brainstem and cervical spinal cord.…”

Section: Discussionmentioning

confidence: 99%

Surgical management of subependymoma in a cat

Sakamoto

Chambers

Fujimoto³

et al. 2022

Vet Record Case Reports

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A 10‐year‐old, domestic shorthair cat was presented with a 7‐month history of anorexia and 2‐month history of severe obtundation. Neurological examination revealed proprioceptive ataxia and decreased postural reactions in the four limbs. On magnetic resonance imaging, a contrast‐enhanced mass lesion dorsal to the obex region was found, causing cerebellar and brainstem compression. The mass was aspirated by an ultrasonic aspirator and complete removal was achieved. After surgery, the mental status and appetite of the cat was markedly improved. On histopathological examination, the mass was diagnosed as subependymoma. The cat was neurologically normal, and no recurrence was observed on magnetic resonance imaging 3 months postoperatively. There was no evidence of clinical recurrence at 8 month postoperative follow‐up by telephone interview. This is the first description of surgical management of subependymoma in a cat. Subependymoma is a benign tumour in cats, and the prognosis is expected to be good after surgical management as reported in humans.

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Recurrent Subependymoma Treated with Radiosurgery

Cited by 15 publications

References 33 publications

Surgical management and long-term outcome of intracranial subependymoma

Surgical management and long-term outcome of intracranial subependymoma

Subependymomas: An analysis of Clinical and Imaging Features

Surgical management of subependymoma in a cat

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