Recurrent proximal esophageal stricture associated with dysplasia in squamous cell papillomatosis

Esophageal papillomatosis complicated by squamous cell carcinoma in situ

“…Several cases in the literature describe esophageal papillomas that spontaneously regress or remain static with minimal treatment 8,17–19 . ESP has also been reported to cause esophageal stricture 20 . One report describes papillomatosis of the distal esophagus that, over the course of two years, spread through the bronchial tree and ultimately caused the patient's death 21 .…”

“…The association between ESP, HPV and the risk of ESCC is less obvious in ‘low risk’ areas such as Europe and the United States. Clinicians in these ‘low risk’ areas faced with ESP have managed these lesions conservatively, even in some cases where the lesions were large or multiple 18,20,25 . Conversely, the literature contains one report of adenocarcinoma and two reports of SCC in ESP treated with esophagectomy in ‘low risk’ areas 4,5,22 …”

“…8,[17][18][19] ESP has also been reported to cause esophageal stricture. 20 One report describes papillomatosis of the distal esophagus that, over the course of two years, spread through the bronchial tree and ultimately caused the patient's death. 21 Adenocarcinoma of the esophagus has been found within a squamous papilloma that was removed at flexible endoscopy.…”

“…Clinicians in these 'low risk' areas faced with ESP have managed these lesions conservatively, even in some cases where the lesions were large or multiple. 18,20,25 Conversely, the literature contains one report of adenocarcinoma and two reports of SCC in ESP treated with esophagectomy in 'low risk' areas. 4,5,22 We present a case of squamous cell carcinoma in situ within a large squamous papilloma of the esophagus, diagnosed after esophagectomy.…”

Oesophageal papillomatosis, not amenable to endoscopic therapies, treated with oesophagectomy

“…Waluga et al 7 and Reynoso et al 8 reported a poorly differentiated squamous cell carcinoma of the oesophagus and an oesophageal squamous cell carcinoma in situ, respectively (in oesophagectomy specimens) in the settings of oesophageal squamous papillomatosis. Narayani and Young9 also reported development of high-grade dysplasia in the setting of oesophageal papillomatosis. The most prevalent location of oesophageal papillomas was reported in the distal oesophagus (similar to our case) 3…”