Esophageal papillomatosis complicated by squamous cell carcinoma in situ

Reynoso, Jose; Davis, Richard E.; Daniels, Wayne W.; Awad, Ziad T.; Gatalica, Zoran; Filipi, Charles J.

doi:10.1111/j.1442-2050.2004.00438.x

Cited by 25 publications

(42 citation statements)

References 28 publications

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“…Development of extensive esophageal squamous papillomas, otherwise known as squamous papillomatosis of the esophagus, is even less common. Review of the English literature identifies only eight cases of papillomatosis of the esophagus (3)(4)(5)(6)(7)(8)(9)(10). The first reported case involved a patient who received treatment with laser evaporation and alpha-interferon, followed by bleomycin and etoposide phosphate (4).…”

Section: Lesion Note the Sharp Division Between Gastric Antral Type mentioning

confidence: 99%

“…Narayani et al (8) reported the development of high-grade dysplasia in a verrucous-appearing esophagus, with earlier biopsies showing changes only consistent with squamous papillomatosis. Reynoso et al (9) presented a case of squamous carcinoma in situ within esophageal papillomatosis, diagnosed after esophagectomy. Biopsies obtained endoscopically did not demonstrate carcinoma.…”

Section: Lesion Note the Sharp Division Between Gastric Antral Type mentioning

confidence: 99%

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Esophageal Papillomatosis Complicated by Squamous Cell Carcinoma

Attila¹,

Fu²,

Gopinath³

et al. 2009

Canadian Journal of Gastroenterology

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Esophageal papillomatosis is a very rare condition that is believed to have a benign clinical course. Recent reports underscore the potential development of a malignancy in association with squamous papillomatosis of the esophagus. A case of esophageal papillomatosis complicated by the development of esophageal invasive squamous cell carcinoma diagnosed after esophagectomy, despite multiple nondiagnostic endoscopic biopsies, is described. The patient also developed squamous cell carcinoma in the oral cavity and pyloric channel. The finding of extensive esophageal papillomatosis and unremitting dysphagia symptoms should prompt investigations into an underlying associated malignancy.

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Section: Lesion Note the Sharp Division Between Gastric Antral Type mentioning

confidence: 99%

Section: Lesion Note the Sharp Division Between Gastric Antral Type mentioning

confidence: 99%

Esophageal Papillomatosis Complicated by Squamous Cell Carcinoma

Attila¹,

Fu²,

Gopinath³

et al. 2009

Canadian Journal of Gastroenterology

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“…In 1995, Reed et al 5 described a case of a 75-year-old woman in whom an oesophageal papilloma was associated with adenocarcinoma of the oesophagus, marking the first reported case of the malignant potential of this previously believed benign lesion 6. Waluga et al 7 and Reynoso et al 8 reported a poorly differentiated squamous cell carcinoma of the oesophagus and an oesophageal squamous cell carcinoma in situ, respectively (in oesophagectomy specimens) in the settings of oesophageal squamous papillomatosis. Narayani and Young9 also reported development of high-grade dysplasia in the setting of oesophageal papillomatosis.…”

Section: Discussionmentioning

confidence: 99%

Oesophageal papillomatosis, not amenable to endoscopic therapies, treated with oesophagectomy

et al. 2014

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Oesophageal papillomatosis is a very rare entity, with only 10 cases (including ours) reported in the literature. We report a 51-year-old man with a 25-year history of dysphagia with solids and liquids who failed a trial of proton pump inhibitors and fluticasone. His initial endoscopy revealed a viliform mass with dense eosinophilic infiltrate without neoplasia. Endoscopic ultrasound examination revealed a 4×1.6×0.7 cm mucosal hemicircumferential lesion without regional adenopathy. Pathological findings from the oesophagectomy specimen confirmed oesophageal papillomatosis with no malignancy. Surveillance endoscopy 4 months later revealed the lesion had increased in size. Additional ablative therapies failed, and the patient underwent oesophagectomy. Surveillance CT of the chest and abdomen at 3 months and oesophagogastroduodenoscopy at 6 months were negative. This case illustrates that oesophageal squamous papillomatosis not amenable to medical therapy requires surgical treatment.

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“…Entzündung der Schleimhaut im Rahmen einer Refluxerkrankung werden diskutiert [7,9]. Im Uterus, in der Zervix, im Pharynx und in der Anorektal-Region gelten Papillome als Präkanzerose [8,10]. Wiederholt zeigten sich auch im Ösophagus Plattenepithelkarzinome im Rahmen einer Papillomatose, sodass ein Zusammenhang anzunehmen ist [8, 11 -14].…”

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“…Während bei Carr et al 1994 nur in einem von 23 Fällen der Nachweis gelang [7], beschrieb Odze et al 1993 den Nachweis von HPV in 13 von 26 Fällen [4]. Im Uterus, in der Zervix, im Pharynx und in der Anorektal-Region gelten Papillome als Präkanzerose [8,10] Der Zusammenhang zwischen ösophagealen Papillomen und der Ausbildung eines Plattenepithelkarzinoms im Ösophagus ist nicht gesichert, aber anzunehmen [8, 11 -14]. In einer großen retrospektiven Untersuchung mit 155 Patientien mit Papillomen entwickelte sich in zwei Fällen ein Plattenepithelkarzinom.…”

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Extensive Papillomatose des Ösophagus mit maligner Transformation des Plattenepithels

Borgulya¹,

Lorenz²,

Vieth³

et al. 2011

Z Gastroenterol

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While small solitary oesophageal papillomas are uncommon findings that are occasionally identified on routine upper endoscopies, extensive oesophageal papillomatosis is an extremely rare condition with only 9 cases reported in the English literature. We report the case of a 72-year-old woman who was referred for progressive dysphagia for solid food and clinical signs for a reflux disease. Upper endoscopy demonstrated bizarre villous alterations of the mucosa covering the oesophagus subtotally and a suspicious area within these alterations. Histological work-up of the biopsy samples revealed marked papillary hypertrophy and a squamous epithelial carcinoma in situ corresponding to the suspicious lesion. The patient underwent oesophagectomy with cervical gastroesophageal anastomosis and proximal remnants of papillomatous mucosa above the anastomosis were destroyed with endoscopic argon plasma coagulation. In the 2-year follow-up the patient showed limited recurrence of the papillomatosis in the remaining proximal oesophagus containing a circumscript carcinoma that was successfully treated by local endoscopic mucosectomy. Our case strongly underscores the risk of malignant transformation in large areas of papillomatous mucosa and shows that systematic surveillance is essential.

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Esophageal papillomatosis complicated by squamous cell carcinoma in situ

Cited by 25 publications

References 28 publications

Esophageal Papillomatosis Complicated by Squamous Cell Carcinoma

Esophageal Papillomatosis Complicated by Squamous Cell Carcinoma

Oesophageal papillomatosis, not amenable to endoscopic therapies, treated with oesophagectomy

Extensive Papillomatose des Ösophagus mit maligner Transformation des Plattenepithels

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