Recurrent pleomorphic salivary adenoma—the relevance of age at first presentation

McGregor, A.D.; Burgoyne, Margaret; Tan, Kok Chai

doi:10.1016/0007-1226(88)90048-3

Cited by 53 publications

(41 citation statements)

References 18 publications

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“…Of all patients under 30 years of age at first presentation, 42% subsequently developed recurrent disease [15].…”

Section: Discussionmentioning

confidence: 99%

Pleomorphic Adenoma of Parotid in a Young Patient

Patankar¹,

Ma²,

Shewale³

et al. 2013

JCR

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Abstract:Salivary gland tumors are rare, comprising less than 3% of all neoplasia of head and neck region. Pleomorphic adenoma, is the most common salivary gland tumor, accounting for about 60% to 80% of the benign tumors of the salivary glands and for 60% to 70% of all the parotid tumors. Pleomorphic adenoma exhibits wide cytomorphologic and architectural diversity. It is found more commonly between fifth and sixth decades of life, female to male ratio being 2:1. Early diagnosis of this benign neoplasm is important as it has a high rate of recurrence and chances of malignant transformation. Due to few symptoms and the possibility of extension into a hidden site, such as the parapharyngeal space, the tumor can grow for a long time before being diagnosed, and the potential risk of malignant transformation increases over the years with an incidence of 1-7%. We present a case of pleomorphic adenoma diagnosed early in a young patient.

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“…Of all patients under 30 years of age at first presentation, 42% subsequently developed recurrent disease [15].…”

Section: Discussionmentioning

confidence: 99%

Pleomorphic Adenoma of Parotid in a Young Patient

Patankar¹,

Ma²,

Shewale³

et al. 2013

JCR

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“…All recurrences occurred in parotid gland. All authors believed that the chances of recurrence are higher when the first incidence of PA appears before 30 years of age [14,15].…”

Section: Discussionmentioning

confidence: 99%

Pleomorphic Adenoma (Benign Mixed Tumour) of the Minor Salivary Glands of the Upper Lip

Debnath¹,

Adhyapok²

2010

J. Maxillofac. Oral Surg.

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Pleomorphic adenoma is the benign tumor of salivary glands, which originates from the myoepithelial cells and intercalated duct cells. This tumor is more common in major salivary glands. This case report describes a rare and unusual lesion in a 55-year-old female, which was diagnosed as pleomorphic adenoma of the minor salivary glands in the upper lip. The tumor was a circumscribed, submucosal nodule, about 2.0 cm in diameter and was characterized by slow growth and rubbery consistency. Complete excision was performed and the histopathological analysis showed an epithelial salivary gland tumor with islands of plasmacytoid cells, duct like structures, in a variable stroma with chondroid, fibrous and myxoid appearance. No recurrence was observed 1 year after the surgery.

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“…[6][7][8] The major risk factors for recurrence of benign mixed tumors include enucleation and rupture of the tumor at the time of surgical resection. 9 Other associations for increased risk of recurrence include hypocellular tumors, 10 younger age at initial presentation, 11 female patients, 12 and tumors that have already recurred. 13,14 Management recommendations for recurrent tumors include observation, local or extensive surgery, radiation therapy, or a combination of these.…”

Section: Discussionmentioning

confidence: 99%

“…Recurrences are more likely in patients who develop the primary tumor at an earlier age; the reason for this is not entirely clear. 11 Some variation of segmental parotidectomy with facial nerve dissection is the standard surgical approach to treat pleomorphic adenomas of the parotid gland. Enucleation of the tumor yielded the highest recurrence rate (30%) and is no longer a treatment option.…”

Section: Discussionmentioning

confidence: 99%