Recurrent Pantoprazole-Associated Pancreatitis

Murtaza, Ghulam; Khalid, Muhammad; Mungo, Nicolas

doi:10.1097/mjt.0000000000000567

Cited by 12 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While uncommon, these adverse effects also appear to be limited to geriatric human patients that undergo long-term therapy with pantoprazole ( 31 ). Pancreatitis and peripheral edema have also been reported in human patients treated with pantoprazole ( 32 – 34 ). A case of pantoprazole-induced hyperthermia was reported in a human patient, however, none of our study goats had elevated temperatures during the study ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report

et al. 2021

View full text Add to dashboard Cite

Background: Ruminant species are at risk of developing abomasal ulceration, but there is a lack of pharmacokinetic data for anti-ulcer therapies, such as the proton pump inhibitor pantoprazole, in goats.Objective: The primary study objective was to estimate the plasma pharmacokinetic parameters for pantoprazole in adult goats after intravenous administration. A secondary objective was to describe the pharmacokinetic parameters for the metabolite, pantoprazole sulfone, in goats.Methods: Pantoprazole was administered intravenously to six adult goats at a dose of 1 mg/kg. Plasma samples were collected over 36h and analyzed via reverse phase high performance liquid chromatography for determination of pantoprazole and pantoprazole sulfone concentrations. Pharmacokinetic parameters were determined by non-compartmental analysis.Results: Plasma clearance, elimination half-life, and volume of distribution of pantoprazole were estimated at 0.345 mL/kg/min, 0.7 h, and 0.9 L/kg, respectively following IV administration. The maximum concentration, elimination half-life and area under the curve of pantoprazole sulfone were estimated at 0.1 μg/mL, 0.8 h, and 0.2 hr*μg/mL, respectively. The global extraction ratio was estimated 0.00795 ± 0.00138. All animals had normal physical examinations after conclusion of the study.Conclusion: The reported plasma clearance for pantoprazole is lower than reported for foals, calves, and alpacas. The elimination half-life appears to be < that reported for foals and calves. Future pharmacodynamic studies are necessary for determination of the efficacy of pantoprazole on acid suppression in goats.

show abstract

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report

et al. 2021

View full text Add to dashboard Cite

show abstract

“…When used in humans for therapy, multiple adverse events have been reported from patients administered PPIs, mainly skin reactions, nephritis, pancytopenia, anaphylaxis, edema, hepatotoxicity, as well as biochemical changes such as hyponatremia and hypomagnesemia (8)(9)(10)(11)(12)(13)(14). Pantoprazole specifically has been associated with thrombocytopenia, hepatotoxicity, and pancreatitis (9,11,(15)(16)(17). Currently, there are limited data on the toxicity and adverse effects of pantoprazole in veterinary species.…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Clinical Investigation of the Safety and Adverse Effects of Pantoprazole in Hospitalized Ruminants

2020

View full text Add to dashboard Cite

Clinical safety data for the use of gastroprotectants in hospitalized ruminants is lacking. In human patients, multiple adverse effects are possible from the use of pantoprazole including hematologic and electrolyte abnormalities as well as anaphylaxis and edema. The medical records of all hospitalized cattle, goats, and sheep administered pantoprazole over an ∼5-year period were retrospectively analyzed for adverse effects. Seventy-nine eligible patients were observed. Hypomagnesemia was observed after pantoprazole administration in 10 cattle; however, no significant changes were noted when compared to baseline before pantoprazole administration. Significant changes were noted in serum indicators of hepatic and renal function; however, these represented downward trends that were most likely clinically insignificant. Anaphylaxis after pantoprazole administration was not observed; however, seven cattle displayed edema after pantoprazole administration. Veterinary clinicians should be aware of the potential for hypomagnesemia in hospitalized ruminants being administered pantoprazole and monitor patients accordingly. While these preliminary retrospective results indicate that pantoprazole may be a safe adjunctive therapy in hospitalized ruminants, additional studies are necessary to further determine the safety and toxicity of pantoprazole in ruminants.

show abstract

“…Though this drug has been reported to be a rare cause of acute pancreatitis, we believe that it's not the causative agent in our patient, because despite continuation of this drug, the patient recovered from the acute pancreatitis episode and showed improvement in the serum amylase levels. 11 We have observed that our patient had typical clinical features of acute pancreatitis, which is not a commonly recognized complication of kerosene ingestion, with an elevated serum amylase and lipase level. We recommend that treating physicians need to assess the serum amylase and lipase level for patients with kerosene poisoning, who develop abdominal pain.…”

Section: Discussionmentioning

confidence: 53%

Kerosene Poisoning Complicated by Acute Pancreatitis

Sanju

Tullu

Mondkar

et al. 2020

J Pediatr Intensive Care

View full text Add to dashboard Cite

A 6-year-old male child was brought to the emergency pediatric room with alleged history of accidental ingestion of approximately 15 mL kerosene oil. The child developed vomiting shortly after the consumption. Chest radiograph taken 6 hours after ingestion did not show any abnormalities. On the second day of hospital stay, the child started complaining of severe abdominal pain. His serum amylase and lipase levels were elevated significantly, suggesting the development of acute pancreatitis. He was investigated for the other possible causes of acute pancreatitis, which were normal. There is paucity of literature regarding occurrence of acute pancreatitis following kerosene poisoning, both in children, as well as adults, because of its rarity. A high index of suspicion should be kept in mind and a differential diagnosis of acute pancreatitis should be considered in cases of acute kerosene poisoning, who complain of pain in abdomen.

show abstract

Recurrent Pantoprazole-Associated Pancreatitis

Cited by 12 publications

References 4 publications

Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report

Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report

A Retrospective Clinical Investigation of the Safety and Adverse Effects of Pantoprazole in Hospitalized Ruminants

Kerosene Poisoning Complicated by Acute Pancreatitis

Contact Info

Product

Resources

About