Recurrent laryngeal nerve alterations in developing spontaneously hypertensive rats

Abstract

Hypertension development impaired axon growth, affecting mainly the small myelinated fibers. Males and females were affected equally. The alterations of the endoneural blood vessels probably played an important role on the small fibers alterations.

Sensory and Motor Conduction Velocity in Spontaneously Hypertensive Rats: Sex and Aging Investigation

“…Our results showed differences in body weight between male and female SHR and WKY, being males havier than females in both strains. Similar findings were previously described in our laboratory (Licursi de Alcântara et al, 2008; Rodrigues et al, 2011; Sanada et al, 2012; da Silva et al, 2016) and others (Calhoun et al, 1995; Kauser and Rubanyi, 1995; Chen et al, 1997; Chandler and DiCarlo, 1998; Kähönen et al, 1998; Radin et al, 2002; Vlkovicová et al, 2005). Also, WKY animals from both sexes were heavier than SHR, compatible to previous literature reports (Calhoun et al, 1995; Kauser and Rubanyi, 1995; Chen et al, 1997; Chandler and DiCarlo, 1998; Kähönen et al, 1998; Bacáková and Kunes, 2000; Vlkovicová et al, 2005; Rodrigues et al, 2011; Sanada et al, 2012).…”

“…Previous reports suggested that hypertension could cause neuropathy in human beings (Chaco and Viskoper, 1971; Viskoper et al, 1971) but very little investigation on this issue was performed later. Laboratory animal models (Sabbatini et al, 1996; Fazan et al, 1999, 2001; Tomassoni et al, 2004; Fazan et al, 2005; Licursi de Alcântara et al, 2008; Rodrigues et al, 2011; Sanada et al, 2012; Nukada et al, 2016; da Silva et al, 2016) were investigated for the possibility of nerve fiber lesions in hypertension. For all these animal studies, the spontaneously hypertensive rats (SHR) were used for being considered a good model of human essential hypertension (Trippodo and Frohlich, 1981).…”