Recurrent <i>Scedosporium apiospermum</i> skin infection in a renal transplant recipient

Ezzedine, Khaled; Wissing, Karl Martin; Jacobs, Frédérique; Rodriguez, Herbas Maria; Malvy, Denis; Simonart, Thierry

doi:10.1111/j.1468-3083.2008.02722.x

Cited by 10 publications

(2 citation statements)

References 7 publications

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“…Many of these aggressive fungal infections require signifi cant surgical intervention and prolonged antifungal therapy. One case report of cutaneous S. apiospermum infection in a renal transplant recipient describes a relapsing infection after months of antifungal treatment, necessitating chronic treatment [ 41 ].…”

Section: Fungal Skin and Soft Tissue Infectionsmentioning

confidence: 99%

Skin and soft tissue infections in the transplant population

Kotton

2008

Curr Infect Dis Rep

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Solid organ and hematopoietic stem cell transplant recipients are more likely to develop skin and soft tissue infections, which may be caused by common or atypical pathogens. Skin and soft tissue anatomic abnormalities may act as portals of entry for infection, and may result from surgery, venous access, immunosuppressive medications, and other etiologies. Systemic infection may sometimes be recognized by investigation of skin manifestations. Many noninfectious processes of the skin and soft tissues can mimic infection, complicating the diagnosis. Prompt dermatologic consultation and skin biopsy are essential in this vulnerable population. Treatment of infection in transplant recipients may necessitate reduction of immunosuppression, in addition to other adjunctive therapies. Interesting and important new findings about skin and soft tissue infections in transplant recipients are the focus of this review.

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Section: Fungal Skin and Soft Tissue Infectionsmentioning

confidence: 99%

Skin and soft tissue infections in the transplant population

Kotton

2008

Curr Infect Dis Rep

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“…When the patient was pretreated with high-dose chemotherapy for bone marrow transplantation and was thus in a severely immunosuppressed state, the infection relapsed rapidly and became worse, showing that immunosuppression and agranulocytosis play important roles in the development of infection with invasive filamentous fungus. Ezzedine et al (23) believes that S. apiospermum infection occurring in the skin of immunosuppressed patients should be considered a potential invasive infection and should subsequently receive long-term treatment after the first recurrence. In the present case, after almost three months of treatment with voriconazole, the skin lesion was almost healed and the dissemination was stopped.…”

Section: A B C Dmentioning

confidence: 99%

Dermatic Scedosporium Apiospermum Infection after Autologous Bone Marrow Transplantation

Jiang

et al. 2013

Intern. Med.

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Infection with Scedosporium apiospermum (S. apiospermum) is rare, although it is associated with a high fatality rate, especially in immunosuppressed patients. A 23-year-old man with acute myelogenous leukemia (AML) (M2) who was pretreated with chemotherapy for autologous bone marrow transplantation developed a skin ulcer on the left groin. After a culture study demonstrated the presence of S. apiospermum, voriconazole was administered and the lesion rapidly improved. Since a diagnosis of S. apiospermum continues to depend on the results of a fungal culture and most isolates of S. apiospermum are resistant to amphotericin B, voriconazole should be considered as the first choice when "mold" is thought to be the causative organism.

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A case of cutaneous Scedosporium apiospermum infection in a patient on a janus kinase inhibitor

Born

Germanas

2023

Skin Health and Disease

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Scedosporium apiospermum is a mold that is usually found in soil and polluted water, but has also been linked to contaminated ambient air in hospitals. This fungus typically behaves as a rare opportunistic pathogen affecting immunocompromised patients in whom disseminated disease can readily occur, causing shock and multiorgan failure. We report the first case of cutaneous Scedosporium apiospermum infection in a patient with rheumatoid arthritis treated with a Janus kinase inhibitor. We also reviewed other cutaneous manifestations of Scedosporium apiospermum reported between 2003 and 2022.

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Recurrent Scedosporium apiospermum skin infection in a renal transplant recipient

Abstract: 7 Calleja C, Pascussi JM, Mani JC, Maurel P, Vilarem MJ. The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor. Nat Med 1998; 4: 92-96. 8 Tsankov N, Krasteva M. On rifampin treatment of psoriasis.

Cited by 10 publications

References 7 publications

Skin and soft tissue infections in the transplant population

Skin and soft tissue infections in the transplant population

Dermatic Scedosporium Apiospermum Infection after Autologous Bone Marrow Transplantation

A case of cutaneous Scedosporium apiospermum infection in a patient on a janus kinase inhibitor

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