Recurrent hydrochlorothiazide-induced pulmonary edema

Mas, A. Gelabert; Jordana, R.; Vallés, Juana; Cervantes, Manuel

doi:10.1007/s001340050581

Cited by 16 publications

(10 citation statements)

References 9 publications

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“…In addition, some patients receive mechanical ventilation. [8][9][10] Although some patients were administered corticosteroids, 8,11,12 the use of these agents is not supported by clinical evidence. Most patients respond to treatment and discontinuation of hydrochlorothiazide, with symptoms resolving in a mean of 3.5 ± 0.6 days.…”

Section: Discussionmentioning

confidence: 99%

Hydrochlorothiazide‐Induced Noncardiogenic Pulmonary Edema: An Underrecognized Yet Serious Adverse Drug Reaction

et al. 2005

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Noncardiogenic pulmonary edema is a rare but potentially life-threatening complication of hydrochlorothiazide therapy. We describe three patients who developed this serious adverse reaction. A 64-year-old woman developed dypsnea and hypotension within 60 minutes of taking a single dose of hydrochlorothiazide 25 mg. She was admitted to the critical care unit with acute respiratory failure and subsequent multiple-organ dysfunction. The second patient was a 56-year-old woman who experienced sudden onset of shortness of breath that developed 10 minutes after taking a single dose of hydrochlorothiazide 25 mg. The third was a 59-year-old woman who developed sudden onset of shortness of breath, nausea, vomiting, and diarrhea after her first dose of hydrochlorothiazide-triamterene. All three women had a history of a similar, albeit minor, reaction to a thiazide diuretic. Review of the literature identified 36 additional cases of noncardiogenic pulmonary edema after thiazide use. The patients developed symptoms 10-150 minutes after ingestion of hydrochlorothiazide or another thiazide. Symptoms can occur on first exposure to the drug or in patients taking the drug intermittently. Of interest, 90% of documented cases occurred in women. With the increasing use of thiazide diuretics in the treatment of hypertension, clinicians need to be aware of the possible association of these drugs with the development of noncardiogenic pulmonary edema.

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Section: Discussionmentioning

confidence: 99%

Hydrochlorothiazide‐Induced Noncardiogenic Pulmonary Edema: An Underrecognized Yet Serious Adverse Drug Reaction

et al. 2005

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“…It is based mainly on the temporal relationship between ingestion of the drug and development of symptoms provided that the cardiogenic origin of pulmonary congestion is excluded. In several cases described, the correct diagnosis was made upon unintentional hydrochlorothiazide rechallenge [2,6].…”

Section: Discussionmentioning

confidence: 96%

Hydrochlorothiazide induced pulmonary edema—a rare side effect of common diuretic drug

Solař¹,

Ceral²,

Kvasnička³

2006

International Journal of Cardiology

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“…En el caso de las recurrencias, la gravedad del cuadro clínico aumenta 10,11 . En nuestra paciente no podemos asegurar que esto sea una recurrencia, ya que no existe documentación fiable del primer episodio, suponemos que fue leve ya que revirtió la sintomotalogía a las pocas horas.…”

Section: Discussionunclassified

“…En cuanto a la patogenia, se ha postulado la existencia de un mecanismo inmunológico (reacción antígeno-anticuerpo) que no ha podido ser demostrado. Probablemente se trate de una reacción idiosincrática similar a las descritas por otros fármacos como narcóticos y salicilatos 10,11 . Algunos autores han observado un descenso en la concentración de IgG y complemento lo que hace sospechar un deposito de IgG en la membrana alveolar.…”

Section: Discussionunclassified

Edema pulmonar agudo por uso de tiazidas, ¿existe falla cardíaca?: Comunicación de un caso

Andresen

M²,

E³

et al. 2007

Rev. méd. Chile

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Acute pulmonary edema caused by thiazides is uncommon and of difficult diagnosis. It is considered an idiosyncratic reaction and the physiopathology or cardiac function changes are not well known. We report a 60 year-old female with a thiazide induced acute pulmonary edema who was followed with serial measurements of type B n-terminal natriuretic peptide fraction as marker for cardiac dysfunction. There was a significant elevation of the peptide, not associated to evidences of ventricular dysfunction. Its normalization paralleled the resolution of the clinical picture.

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Recurrent hydrochlorothiazide-induced pulmonary edema

Abstract: Hydrochlorothiazide-induced pulmonary edema is an unusual but life-threatening adverse reaction. It causes hypoxemia, hypotension, tachycardia, fever, and occasionally electrocardiographic and echocardiographic abnormalities. The mechanism of production is, probably, idiosyncratic.

Cited by 16 publications

References 9 publications

Hydrochlorothiazide‐Induced Noncardiogenic Pulmonary Edema: An Underrecognized Yet Serious Adverse Drug Reaction

Hydrochlorothiazide‐Induced Noncardiogenic Pulmonary Edema: An Underrecognized Yet Serious Adverse Drug Reaction

Hydrochlorothiazide induced pulmonary edema—a rare side effect of common diuretic drug

Edema pulmonar agudo por uso de tiazidas, ¿existe falla cardíaca?: Comunicación de un caso

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