Recurrent Gustatory Sweating (Frey Syndrome) After Intracutaneous Injection of Botulinum Toxin Type A

Laccourreye, O.; Akl, Elie A.; Gutiérrez-Fonseca, Raimundo; Garcia, Dominique; Brasnu, Daniel; Bonan, Brigitte

doi:10.1001/archotol.125.3.283

Cited by 101 publications

(60 citation statements)

References 8 publications

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“…In studies with a longer follow-up, the effectiveness was temporary and recurrence rate was higher. 20,41,43 However, because the severity of recurrent Frey syndrome is reduced when compared with the severity of the initial Frey syndrome and because recurrent Frey syndrome remains amenable to reinjection of botulinum toxin A, intracutaneous injection of botulinum toxin A is suggested to be the first-line treatment option in patients with Frey syndrome. 20,43 Botulinum toxin A treatment appears to be effective in almost all patients, minimally invasive, well tolerated and long-lasting (>6 months) and can be repeated.…”

Section: Treatmentmentioning

confidence: 99%

Management of frey syndrome

2007

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Almost all patients who undergo parotidectomy will to some extent develop Frey syndrome (auriculotemporal syndrome or gustatory sweating) after surgery, because of aberrant regeneration of cut parasympathetic fibers between otic ganglion and subcutaneous vessels. However, only the minority of these patients needs treatment. The syndrome consists of gustatory sweating, flushing, and warming over the preauricular and temporal areas. Thick skin flap and partial superficial parotidectomy are the most important techniques to minimize the risk of developing symptomatic Frey syndrome. Intracutaneous injection of botulinum toxin A is an effective, long-lasting, and well-tolerated treatment of Frey syndrome. If recurrence occurs, the treatment can be repeated.

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Section: Treatmentmentioning

confidence: 99%

Management of frey syndrome

2007

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“…Schulze-Bonhage et al [30], Bjerkhoel and Trobbe [4], Laccourreye et al [24] and Arad-Cohen and Blitzer [2] have confirmed the effectiveness of the treatment with their data. The longest follow-up was reported by Laccourreye et al [25] and exceeded a period of 3 years, demonstrating a linear regression in the effectiveness of BT, although no factors appeared to be statistically related to the duration of the result. On the other hand, the severity of the recurrent Frey's syndrome was diminished 20%-90% compared to the initial status.…”

Section: Discussionmentioning

confidence: 76%

Treatment of Frey’s syndrome using botulinum toxin type A

Rodopoulou¹,

Keramidas²,

Metaxotos³

et al. 2001

Eur J Plast Surg

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Of 49 patients to undergo parotidectomy during the past 6 years in our department, 18 (36.7%) subsequently noticed gustatory sweating. Of those 18, ten (20.4%) considered the sweating to be severe and very uncomfortable. Nine of the patients underwent Minor's starch iodine test and Frey's syndrome was confirmed. These patients were treated with an intracutaneous injection of 2.5 IU of botulinum toxin A (Botox, Allergan, USA) into the affected skin area. It was necessary to reinject the medicine into a small temporal hair-covered area in one patient, in whom Minor's test did not appear clearly positive. The patients were subsequently evaluated with Minor's test at 1 week, and then at 2, 6, 12 and 14 months, and were shown to be free of symptoms without any side effects. This preliminary report confirms that an intracutaneous injection of BT is an effective and safe treatment option for Frey's syndrome. Further follow-up of the patients will be required to evaluate the duration of the therapeutic effect.

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“…One patient had transient facial paresis following BT treatment on day 3. Laccourreye et al 14 , in a follow-up study of 33 FS patients treated with BT, found recurrence rates of 27% in ther first year, 63% in the second and 92% in the thirdy year, by means of clinical assessment and Minor iodine-starch test. Nevertheless, patients reported prolonged improvement and recurrence remained amenable to reinjection of BT.…”

Section: Discussionmentioning

confidence: 97%

Botulinum toxin for treatment of Frey's syndrome: report of two cases

Teive¹,

Troiano²,

Robert

et al. 2003

Arq. Neuro-Psiquiatr.

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Frey's syndrome is a phenomenon of hemifacial flushing and sweating after gustatory stimulus, usually secondary to surgical trauma over the parotid gland, although other injury mechanisms may be seen. It is accepted as a result of aberrant regeneration of facial autonomic nerve fibers. Treatment evolved from ineffective medical and surgical approaches to botulinum toxin. We evaluate the effectiveness and safety of botulinum toxin in the treatment of this complication in two patients.

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Recurrent Gustatory Sweating (Frey Syndrome) After Intracutaneous Injection of Botulinum Toxin Type A

Cited by 101 publications

References 8 publications

Management of frey syndrome

Management of frey syndrome

Treatment of Frey’s syndrome using botulinum toxin type A

Botulinum toxin for treatment of Frey's syndrome: report of two cases

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