Recurrent Guillain-Barre Syndrome as a Complication of Immune Reconstitution in HIV

Mäkelä, P H; Howe, Laura D; Glover, S. C.; Ferguson, Ian T.; Pinto, Ashwin; Gompels, Mark

doi:10.1053/jinf.2001.0917

Cited by 38 publications

(29 citation statements)

References 12 publications

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“…Most inflammatory cases have been shown to be associated with additional or other coinfections of the CNS than with JC virus [47]. Additional neurologic manifestations of IRIS were described due to toxoplasmosis, cerebral cryptococcosis, intracerebral M. avium infection [48], Guillain-Barré syndrome [49], focal lesions, myelopathy, and encephalitis [1,2••]. Some of these cases may be separated from possible differential diagnoses, like coinfection or failure of HAART, in the specific CNS compartment.…”

Section: Diseases Of the Central Nervous Systemmentioning

confidence: 99%

Immune restoration inflammatory syndromes: The dark side of successful antiretroviral treatment

Stoll

Schmidt²

2003

Curr Infect Dis Rep

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The prevalence of cellular immunodeficiency has increased due to rising use of immunosuppressive therapies and the pandemic spread of HIV infection. More recently, the introduction of highly active antiretroviral therapy (HAART) in HIV has led to significant immune reconstitution, even in patients with previously long-lasting secondary immunodeficiency. HAART reduces morbidity and mortality in HIV infection and also changes the clinical course of prevalent subclinical opportunistic infections or autoimmune diseases. Atypical inflammatory disorders develop after initiation of HAART and have been summarized as "immune reconstitution syndrome," "immune restoration disease," and "immune restoration inflammatory syndrome." However, diagnostic criteria and standards of therapy are yet to be defined. The awareness for these diseases is of increasing importance from a clinical point of view. This review summarizes the variety of immunoreconstitution disorders and describes possible diagnostic pitfalls. We also propose possible therapeutic options.

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Section: Diseases Of the Central Nervous Systemmentioning

confidence: 99%

Immune restoration inflammatory syndromes: The dark side of successful antiretroviral treatment

Stoll

Schmidt²

2003

Curr Infect Dis Rep

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“…GBS may occur in HIV-infected patients at the time of seroconversion, even with normal CD4 counts, and can be the presenting symptom or seen in the setting of the immune reconstitution syndrome (13)(14)(15)(16). Nucleoside analogue reverse transcriptase inhibitors (NRTIs), a backbone component of HAART, have also been related to GBS in HIV-infected individuals in association with the immune reconstitution syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…Proposed mechanisms include a direct action of HIV on the nerve by neurotropic strains or formation of autoantibodies against myelin secondary to the abnormal immunoregulation caused by the HIV infection (20). In the setting of immune reconstitution syndrome, there is a reemergence of previously anergic lymphocytes upon viral suppression with HAART (13)(14)(15)(16). Cell-mediated immunity is known to play a major role in the pathogenesis of GBS.…”

Section: Discussionmentioning

confidence: 99%

Ascending Paralysis Associated with Hiv Infection

Afzal

Benjamin

Gummelt

et al. 2015

Baylor University Medical Center Proceedings

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“…Weitere neurologische Manifestationen im Rahmen eines IRIS wurden beschrieben im Zusammenhang mit Toxoplasmose, zerebraler Kryptokokkose, intrazerebraler Mycobacterium-avium-Infektion, Guillain-Barré-Syndrom, Parvovirus-B19-Infektion, fokalen Läsionen, Enzephalitis und Myelopathie des Rückenmarks [6,14,24,33].…”

Section: Erkrankungen Des Zentralen Nervensystemsunclassified

Immunrekonstitutionssyndrome (IRIS)

et al. 2004

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Increase of prevalence of certain immunodeficiencies is caused by more frequent use of immunosuppresive treatment, by advances in supportive care of immunodeficient individuals and by the pandemic spread of HIV-infection respectively. Highly active antiretroviral treatment (HAART) is able to reconstitute the impaired immunity in the HIV-infected individual and therefore to reduce morbidity and mortality. On the other hand paradoxical exacerbation of inflammatory or opportunistic diseases may develop during immunoreconstitution. By their distinct pathophysiological, clinical and therapeutic particularities these disease have been summarized as Immune Restoration Inflammatory Syndromes (IRIS). This review summarizes the variety of immunoreconstitution disorders and describes possible diagnostic pitfalls. Potential therapeutic options and an algorithm for the classification of the syndrome are proposed.

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Recurrent Guillain-Barre Syndrome as a Complication of Immune Reconstitution in HIV

Cited by 38 publications

References 12 publications

Immune restoration inflammatory syndromes: The dark side of successful antiretroviral treatment

Immune restoration inflammatory syndromes: The dark side of successful antiretroviral treatment

Ascending Paralysis Associated with Hiv Infection

Immunrekonstitutionssyndrome (IRIS)

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