Recurrent Corneal Erosion Syndrome

Das, Sujata; Seitz, Berthold

doi:10.1016/j.survophthal.2007.10.011

Cited by 92 publications

(88 citation statements)

References 78 publications

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“…Nevertheless, the immunohistochemical data supports the clinical observation that, besides visual disturbances, most patients with LCD suffer from recurrent and slowly healing corneal epithelial erosions [8]. Clinically, patients with recurrent erosions reveal very weak adhesion of the corneal epithelium to the underlying stroma [9]. We focused on basement membrane constituents and cell-matrix adhesion molecules, since these components cooperate to anchor epithelial cells to the underlying stroma.…”

Section: Discussionmentioning

confidence: 79%

Alterations of epithelial adhesion molecules and basement membrane components in lattice corneal dystrophy (LCD)

Resch

Schlötzer‐Schrehardt

Hofmann-Rummelt

et al. 2009

Graefes Arch Clin Exp Ophthalmol

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Immunohistochemical and electron microscopic evidence of structural alterations was found in LCD compared to normal corneas concerning cell-matrix adhesion molecules and basement membrane components. These alterations were more pronounced in dystrophic corneas with subepithelial amyloid deposits than in those with stromal deposits. Histopathological findings may correspond to reduced cell-matrix interactions and partly explain delayed epithelial healing in patients with lattice corneal dystrophy.

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Section: Discussionmentioning

confidence: 79%

Alterations of epithelial adhesion molecules and basement membrane components in lattice corneal dystrophy (LCD)

Resch

Schlötzer‐Schrehardt

Hofmann-Rummelt

et al. 2009

Graefes Arch Clin Exp Ophthalmol

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“…However, we must be cautious in using PTK (or any other surgical technique) a short time after LASIK, even with the small ablation depth performed in our cases. 33,34 Our 2 patients comprise a small case series with short-term follow-up. Most studies show that EBMD tends to occur within the first 2 years after PTK, 28,31 but the fast, subjective visual improvement in our cases is promising.…”

Section: Discussionmentioning

confidence: 99%

Early phototherapeutic keratectomy for basement membrane dystrophy after laser in situ keratomileusis

García-González¹,

Teus²

2009

Journal of Cataract and Refractive Surgery

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Phototherapeutic keratectomy (PTK) was performed to treat preexisting silent epithelial basal membrane dystrophy 1 month after laser in situ keratomileusis in 2 patients (4 eyes). The symptoms resolved dramatically during the follow-up period, with the patients reporting an immediate subjective visual improvement. At the last follow-up visit, 3 months after PTK, the eyes were asymptomatic, the epithelium was regular, no corneal erosions recurred, and the visual acuity was normal with no fluctuations. No eye developed haze greater than grade 1. There was no postoperative hyperopic shift, and no eye lost lines of best spectacle-corrected visual acuity.

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“…It has been shown that excimer photorefractive keratectomy and laser in situ keratomileusis alter the wound healing response of the cornea [11]. The effects of PTK on wound healing have been described and are indeed desired in the treatment of RCE to improve the postoperative epithelial adhesion [5, 12], but there is no known effect of excimer laser treatment on the speed of corneal epithelialization. To avoid any bias between the groups, both groups were treated with the same laser settings under the same conditions, and care was taken to apply local anesthesia and fluorescein staining necessary for the photographs in equal dosages at the same time intervals.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to local medical treatment, bandage lenses, debridement and anterior stromal puncture, the condition can be treated with excimer laser phototherapeutic keratectomy (PTK) [2,3,4]. Due to low recurrence rates with few complications, this procedure is now widely recommended as treatment for RCE not responding to medical therapy [5]. …”

Section: Introductionmentioning

confidence: 99%

Corneal Re-Epithelialization following Phototherapeutic Keratectomy for Recurrent Corneal Erosion as in vivo Model of Epithelial Wound Healing

et al. 2009

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Background: This placebo-controlled double-blind study examined the suitability of recording corneal epithelialization after phototherapeutic keratectomy (PTK) as a model of epithelial wound healing. Methods: Eighteen patients with recurrent corneal erosion were randomized into 2 groups, and received PTK with a 7-mm ablation zone. Postoperatively, one group was treated with an ointment containing 5% dexpanthenol and the other with the ointment vehicle without dexpanthenol. The epithelial lesions were recorded by digital slit-lamp photographs with fluorescein staining at fixed intervals until epithelial closure. The size of the epithelial defect was measured, and the average time until epithelial closure was calculated. Reliability of measurements was tested by calculating Cronbach’s α from measurements at the same point in time. Results: Photographs could be taken at all scheduled examinations. The measured size of the epithelial defects showed a high reliability (Cronbach’s α = 0.994). The average time needed for epithelial closure was 57.5 h in the treatment group and 64.8 h in the placebo group (p = 0.177). Conclusions: Planimetric measurement of slit-lamp photographs of standardized epithelial defects is an adequate method for monitoring the progress of corneal epithelial wound healing. Although wounds treated with dexpanthenol showed a slightly shorter average healing time, the difference to the placebo was not significant.

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Recurrent Corneal Erosion Syndrome

Cited by 92 publications

References 78 publications

Alterations of epithelial adhesion molecules and basement membrane components in lattice corneal dystrophy (LCD)

Alterations of epithelial adhesion molecules and basement membrane components in lattice corneal dystrophy (LCD)

Early phototherapeutic keratectomy for basement membrane dystrophy after laser in situ keratomileusis

Corneal Re-Epithelialization following Phototherapeutic Keratectomy for Recurrent Corneal Erosion as in vivo Model of Epithelial Wound Healing

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