Recurrent cerebral metastasis from a cardiac myxoma: case report and review of literature

Rodrigues, Desiderio; Matthews, Nigel Shaun; Scoones, David; Aziz, Farooq; Nath, Fred

doi:10.1080/02688690601000394

Cited by 10 publications

(9 citation statements)

References 4 publications

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“…Bone and brain metastases from glandular cardiac myxomas have been reported in the recent literature. [31][32][33][34][35][36][37][38] The most frequent metastatic site for cardiac myxomas is cerebrum. 33 Several reports have reviewed cerebral metastasis cases.…”

Section: Discussionmentioning

confidence: 99%

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Clinical profile of cardiac myxoma: 11 years experience of 90 cases

Rahman¹,

Ali²,

Kabir³

et al. 2016

Bangladesh Heart J

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Introduction: Cardiac myxoma is a benign neoplasm that represents the most common primary tumour of the heart. Because of nonspecific symptoms, early diagnosis may be a challenge. Although the left atrium is the most commonly involved site of origin in 75% of cases, it can arise from any of the cardiac chambers. Symptoms from a cardiac myxoma are more pronounced when the myxomas are left-sided, racemosus, and over 5 cm in diameter. Symptoms are produced by mechanical interference with cardiac function or embolization. Being intravascular and friable, myxomas account for most cases of tumor embolism. The site of embolism is dependent upon the location (left or right atrium) and the presence of an intracardiac shunt. Most atrial myxomas are benign and can be removed by surgical resection.Objectives: To see clinical presentation and echocardiographic profile of cardiac myoxomas.Methods: 90 cardiac myxoma patients who admitted both in cardiology and cardiac surgery departments of National Institute of Cardiovascular Diseases (NICVD), Dhaka from August 2003 to July, 2014 were studied clinically and by echocardiogram. Clinical histories were reviewed, noting age, gender, and clinical presentation.Results: There were 30 males and 60 females, ages ranged from 17 to 76 years. The commonest clinical feature was dyspnoea (94.44%), followed by palpitation (76.67%), chest discomfort (74.44%), constitutional symptoms (50%), pedal oedema (20%), syncope (14.44%), and embolization (7.7%). The mean duration of symptoms was 09.7 months.Conclusion: The clinical presentation of cardiac myxoma is often nonspecific, so high index of clinical suspicion is important for its early and correct diagnosis. The size and appearance of the myxomas correlated with the presenting symptoms.Bangladesh Heart Journal 2016; 31(1) : 18-22

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Section: Discussionmentioning

confidence: 99%

“…33 Several reports have reviewed cerebral metastasis cases. 34,35 Since most myxomas are located in the left atrium, systemic embolism is particularly frequent. The tumor fragments metastasized to cerebral vessel walls may penetrate through the vessel wall, forming intra-arterial metastases.…”

Section: Discussionmentioning

confidence: 99%

Clinical profile of cardiac myxoma: 11 years experience of 90 cases

Rahman¹,

Ali²,

Kabir³

et al. 2016

Bangladesh Heart J

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“…Bone and brain metastases from glandular cardiac myxomas have been reported in the recent literature. [30][31][32][33][34] The most frequent metastatic site for cardiac myxomas is cerebrum. 32 Several reports have reviewed cerebral metastasis cases.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Myxoma- A Study of 10 Cases

Murarkar¹,

Sulhyan²,

Deshmukh³

et al. 2018

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BACKGROUND Myxoma is the most common primary tumour of the heart in adults with age range of 30 to 60 years. About 90% of them are situated in left atrium. Here we present a study of 10 cases of cardiac myxomas. MATERIALS AND METHODS A retrospective analysis of 10 cases of cardiac myxomas received in Department of Pathology, Government Medical College, Miraj between December 2007 to November 2016 was done. All the surgical specimens were fixed in 10% formalin. After fixation, gross examination was done which included size, shape, color, consistency and cut surface. The gross histopathological tissue sampling was done as per the standard procedures. After routine tissue processing the slides were stained with haematoxylin and eosin. RESULTS On gross examination all the specimens were received in multiple pieces of varying sizes. The external surface of all pieces were smooth and whitish. Cut surface of all specimens were gelatinous and few showed dark brown areas. Microscopy of all the cases showed similar histomorphological features. Sections showed a well circumscribed tumour composed of oval to spindle or stellate shaped (myxoma) cells having bland vesicular nuclei and eosinophilic cytoplasm arranged singly as well as in syncytium, cords, solid clusters and at places forming rings in close association with the blood vessels. The cells were set in abundant myxoid and hyalinised stroma. Some sections showed extensive areas of haemorrhage, focal areas of fibrosis, focal dense infiltration by mononuclear cells, polymorphs and haemosiderophages. CONCLUSION Myxoma is the most common cardiac tumour with left atrium being the commonest site.

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“…The natural history of these lesions, including the types of patients more susceptible, the risk of hemorrhage, the optimum monitoring strategy, and triggers for surgical intervention are all unknown. Patients presenting with cerebral hemorrhage of unknown etiology should undergo cardiac imaging to rule out atrial myxoma, as up to 50% of patients with myxomas present initially with stroke [3,4,10,18,29,30].…”

Section: Discussionmentioning

confidence: 99%

Rupture of Cerebral Myxomatous Aneurysm Months After Resection of the Primary Cardiac Tumor

et al. 2010

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Recurrent cerebral metastasis from a cardiac myxoma: case report and review of literature

Abstract: We report the case of a 65-year-old patient who had complete excision of an atrial myxoma and subsequently presented to our unit with recurrent cerebral metastasis. The case demonstrates that cardiac myxoma despite benign histological appearance is capable of metastatic spread.

Cited by 10 publications

References 4 publications

Clinical profile of cardiac myxoma: 11 years experience of 90 cases

Clinical profile of cardiac myxoma: 11 years experience of 90 cases

Cardiac Myxoma- A Study of 10 Cases

Rupture of Cerebral Myxomatous Aneurysm Months After Resection of the Primary Cardiac Tumor

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Recurrent cerebral metastasis from a cardiac myxoma: case report and review of literature

Abstract: We report the case of a 65-year-old patient who had complete excision of an atrial myxoma and subsequently presented to our unit with recurrent cerebral metastasis. The case demonstrates that cardiac myxoma despite benign histological appearance is capable of metastatic spread.

Cited by 10 publications

References 4 publications

Clinical profile of cardiac myxoma: 11 years experience of 90 cases

Clinical profile of cardiac myxoma: 11 years experience of 90 cases

Cardiac Myxoma- A Study of 10 Cases

Rupture of Cerebral Myxomatous Aneurysm Months After Resection of the Primary Cardiac Tumor

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Clinical profile of cardiac myxoma: 11 years experience of 90 cases

Clinical profile of cardiac myxoma: 11 years experience of 90 cases