“…In several reports, recurrences were diagnosed within the first 24 months [21,26,41]. Though early recurrences occurring within the first 6 months have been reported to have a less favorable prognosis [21], we -like others [36,41] -did not find a difference in outcome compared to recurrences occurring later.…”
Section: Discussioncontrasting
confidence: 31%
“…Radiation therapy remains the treatment of choice for patients with pelvic recurrences following primary surgery [21,46].…”
Section: Discussionmentioning
confidence: 99%
“…The prognosis of patients with recurrences following radical surgery is poor [5,21,22,42,44], reports with regard to prognostic factors are sparse. Radiation therapy has been the standard treatment for pelvic recurrences of carcinoma of the cervix after primary surgery [21,46].…”
The probability of controlling recurrence mostly depends on a small tumor burden with the possibility of brachytherapy and/or complete surgery. Aggressive treatment modalities like radiochemotherapy and/or higher radiation doses are needed, especially for recurrences with infiltration of the pelvic wall and/or with macroscopic tumor.
“…In several reports, recurrences were diagnosed within the first 24 months [21,26,41]. Though early recurrences occurring within the first 6 months have been reported to have a less favorable prognosis [21], we -like others [36,41] -did not find a difference in outcome compared to recurrences occurring later.…”
Section: Discussioncontrasting
confidence: 31%
“…Radiation therapy remains the treatment of choice for patients with pelvic recurrences following primary surgery [21,46].…”
Section: Discussionmentioning
confidence: 99%
“…The prognosis of patients with recurrences following radical surgery is poor [5,21,22,42,44], reports with regard to prognostic factors are sparse. Radiation therapy has been the standard treatment for pelvic recurrences of carcinoma of the cervix after primary surgery [21,46].…”
The probability of controlling recurrence mostly depends on a small tumor burden with the possibility of brachytherapy and/or complete surgery. Aggressive treatment modalities like radiochemotherapy and/or higher radiation doses are needed, especially for recurrences with infiltration of the pelvic wall and/or with macroscopic tumor.
“…Die Gesamtprognose der Beckenwandrezidive ist ausgesprochen schlecht mit 0-15% 5-Jahres-Überlebensrate [9,19,22]. Bessere Ergebnisse werden aus der Mayo-Klinik berichtet, wo ebenfalls eine intraoperative Bestrahlung nach maximalem chirurgischen Debulking eingesetzt wird [15].…”
Section: Pelvines Rezidiv An Der Beckenwandunclassified
“…Although therapy re sults seem to be favorable, relapses [18] occur in about 10-20% of the cases. Patients with tumor relapse, however, have a very poor prognosis: only 10-20% of them survive for 2 years after the diagnosis of relapse [18]. Therefore, the prevention of re lapses should be the main target of therapy.…”
Background: The present retrospective study attempts to evaluate the significance of nicotine abuse as a prognostic factor for cervical carcinoma in addition to factors such as histological type, adjuvant radiotherapy, age, histological grading, tumor infiltration of the corpus uteri, tumor size and lymph node metastases. Patients and Methods: Between 1981 and 1987, 163 patients operated at our department or referred to postoperative radiotherapy fulfilled the inclusion criteria: histopathological stage lb (International Federation of Gynecology and Obstetrics, FIGO) radical hysterectomy with pelvic lymphadenectomy, and known history of smoking. Results: Univariate and multivariate analyses confirmed that in addition to the factors tumor size [tumor infiltration of the cervix > 2/3 vs. < 2/3: relative risk (RR) = 4.48; 95% CI = 1.28 -15.72] and pelvic lymph node metastases (positive vs. negative: RR = 3.63; 95% CI = 1.53-8.60). nicotine abuse (yes vs. no: RR = 3.03; 95% CI = 0.14-0.75) is of significant importance for the relapse-free survival. Conclusion: Therefore smokers suffering from cervical carcinoma should be considered as a high-risk group.
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