Recurrent cancer of the breast.Analysis of frequency, distribution, and mortality at the University of California Hospital, 1918 to 1947, inclusive

The 20th century is marked by significant advances regarding the management of breast cancer. A clear trend towards less aggressive surgical operation was constantly noted. Modified radical mastectomy gradually replaced radical mastectomy during the second half of the 20th century, while during the last two decades breast-conservation therapy became the treatment of choice for the treatment of breast cancer. This type of therapy includes segmental mastectomy (either quadrantectomy or lumpectomy) with axillary lymph node dissection, followed by postoperative irradiation. Other significant advances during the 20th century include the introduction of systemic therapy (chemotherapy, hormonal therapy) and radiation therapy. Better patient follow-up, statistical analysis, development of staging systems and the introduction of frozen section, the development and wide use of mammography (including screening mammography), breast reconstruction following mastectomy and the development of newer diagnostic methods [including breast magnetic resonance imaging and the advanced breast biopsy instrumentation (ABBI)] are other advances that contributed to a better management of breast cancer patients. Sentinel lymph node biopsy has been introduced during the 1990 s in an attempt to reduce morbidity due to axillary lymph node dissection. Despite these advances, breast cancer remains a significant problem and represents a field of active and intense research.

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“…Similar results had been reported by many other groups, including Shimkin et al . (1952), Smithers et al .…”

Section: Introductionsupporting

confidence: 92%

Breast cancer surgery: an historical narrative. Part III. From the sunset of the 19th to the dawn of the 21st century

Sakorafas¹,

Safioleas²

2010

European Journal of Cancer Care

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“…Patients with skeletal metastases have a higher response rate to endocrine therapy (Taylor, 1962) and a more favourable overall prognosis (Shimkin et al, 1954;Papaioannou et al, 1967;Cutler et al, 1969) than those with visceral secondaries.…”

mentioning

confidence: 98%

Oestrogen-receptor status and sites of metastasis in breast cancer

Campbell¹,

Blamey²,

Elston³

et al. 1981

Br J Cancer

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Summary.-The oestrogen receptor (RE) status of the primary tumour has been assessed in 466 of a consecutive series of 550 patients with primary operable breast cancer.All patients were followed up (without treatment) until the development of recurrence or metastases. Distant metastases have so far occurred in 124 patients and 82 have had symptomatic local or regional recurrence.A significant correlation exists between the RE status of the primary tumour and subsequent patterns of metastasis.Symptomatic metastases to regional lymph nodes are more common with REcancers. There is no significant difference in either time of onset or total incidence of distant metastases between patients with RE+ and RE-tumours. Distribution of distant metastases is inflenced by RE status: RE+ tumours tend to recur in bone, RE-tumours show affinity for viscera.

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Chest-Wall Resection for Locally Recurrent Breast Cancer

Snyder¹

1968

Arch Surg

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Recurrent cancer of the breast.Analysis of frequency, distribution, and mortality at the University of California Hospital, 1918 to 1947, inclusive

Cited by 36 publications

References 7 publications

Breast cancer surgery: an historical narrative. Part III. From the sunset of the 19th to the dawn of the 21st century

Breast cancer surgery: an historical narrative. Part III. From the sunset of the 19th to the dawn of the 21st century

Oestrogen-receptor status and sites of metastasis in breast cancer

Chest-Wall Resection for Locally Recurrent Breast Cancer

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