Oestrogen-receptor status and sites of metastasis in breast cancer

Campbell, F. C.; Blamey, R. W.; Elston, C. W.; Nicholson, Robert Ian; Griffiths, K.; Haybittle, J. L.

doi:10.1038/bjc.1981.205

Cited by 78 publications

(26 citation statements)

References 9 publications

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“…The reasons for the preferential dissemination of breast cancer to bone marrow are unknown, but it is thought that simple explanations such as anatomy or blood supply are insufficient (Price, 1994). However, it is known that primary tumours that express oestrogen receptors (ER), monomeric laminin receptors, elevated levels of parathyroid-related protein or lack of c-erb-B2 are more likely to metastasize to bone (Campbell et al, 1981;Kallioniemi et al, 1991;Bundred et al, 1992;Ménard et al, 1994).…”

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confidence: 99%

Investigation of mammary epithelial cell-bone marrow stroma interactions using primary human cell culture as a model of metastasis

et al. 1997

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A model has been established using primary human cell culture to study the cell biology of breast cancer metastasis to bone marrow. Mammary epithelia were obtained in single cell suspension from tumour (macroscopically involved), benign (macroscopically uninvolved) and normal (reduction mammoplasty) breast tissue as well as from locally involved lymph nodes. Stromal layers were generated from long‐term cultures of human bone marrow or from mammary fibroblasts derived from normal or malignant tissue. The interaction between epithelia and stroma has been studied in terms of adhesion of the epithelia to the stroma and their subsequent growth in co‐culture. Our results show that when assayed up to 9 hr after plating, epithelial cells from malignant tissue (14 primary tumours and 9 metastases in lymph nodes) displayed a significant preference for adhesion to bone marrow stroma compared with mammary fibroblasts. In contrast, epithelial cells from 4 normal and 2 of 4 benign samples showed no significant preferential adherence. Subsequent co‐culture of mammary epithelia with each of the 3 stromal layers revealed that under serum‐free, in vitro conditions, bone marrow stromal layers did not provide an advantageous environment for colony growth, in contrast to their ability to provide a preferential substratum for adhesion. Int. J. Cancer 73:690–696, 1997. © 1997 Wiley‐Liss, Inc.

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confidence: 99%

Investigation of mammary epithelial cell-bone marrow stroma interactions using primary human cell culture as a model of metastasis

et al. 1997

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“…The degree of tumour differentiation is a strong correlate of tumour ER (Fisher et al, 1981;Alanko et al, 1984) and is another indicator of tumour aggressiveness. ER content has also been found to relate to the site of initial metastases (Campbell et al, 1981;Williams et al, 1987). It is likely that well differentiated ER + tumours will maintain a low growth rate even after the establishment of a metastasis, which is more often in bone, and tend to have a less aggressive course than metastases to visceral organs (Coleman & Rubens, 1987).…”

Section: Discussionmentioning

confidence: 99%

Oestrogen receptors, nodes and stage as predictors of post-recurrence survival in 457 breast cancer patients

Shek

Godolphin²,

Spinelli³

1987

Br J Cancer

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(Samaan et al., 1981). These subset inconsistencies and differences in RFS observed in early follow-up tend to disappear in the long-term (Howat et al., 1985;Raemaekers et al., 1985;Saez et al., 1983). This unclear role of ER in predicting RFS impacts on the question of whether overall survival is more favourable in ER+ than ER-tumours because of longer RFS, or longer post-recurrence survival (PRS), or both.The association of ER with PRS has been relatively less scrutinized. In a study based on 137 patients with recurrence, Howell et al. (1984) reported that ER+ patients showed a significantly longer survival after relapse than ER-patients. However, this effect was related to response to endocrine therapy. PRS was the same in ER+ nonresponders (n=19) as ER-nonresponders (n= 18) but both groups had significantly worse PRS than ER + responders (n = 24). Howat et al. (1985) in a relatively small study (n=51) found that PRS was better in ER+ patients and suggested this to be predominantly a result of better response to endocrine therapy given for recurrence.We also found a significant association of higher ER concentration and increased PRS among a subset (n=59) which had received endocrine therapy (Godolphin et al., 1981). The patients of that previous study have now been followed up to ten years. Additional patients whose primary tumours were diagnosed and analysed for ER

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“…These tumors may spread more easily, show higher osteolytic activity in vitro (34), and may be associated more frequently with bone metastases (33 (35)(36)(37)(38).…”

Section: Discussionmentioning

confidence: 99%

Estrogens and antiestrogens stimulate release of bone resorbing activity by cultured human breast cancer cells.

Valentin‐Opran¹,

Eilon²,

Saez³

et al. 1985

J. Clin. Invest.

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Patients with advanced breast cancer may develop acute, severe hypercalcemia when treated with estrogens or antiestrogens.In this study, we examined the effects of estrogens and related compounds on the release of bone resorbing activity by cultured human breast cancer cells in vitro. We found that the estrogen receptor positive breast cancer cell line MCF-7 releases bone resorbing activity in response to low concentrations of 17,Bestradiol. Bone resorbing activity was also released in response to the antiestrogen nafoxidine. Other steroidal compounds had no effect on the release of bone resorbing activity.

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Oestrogen-receptor status and sites of metastasis in breast cancer

Cited by 78 publications

References 9 publications

Investigation of mammary epithelial cell-bone marrow stroma interactions using primary human cell culture as a model of metastasis

Investigation of mammary epithelial cell-bone marrow stroma interactions using primary human cell culture as a model of metastasis

Oestrogen receptors, nodes and stage as predictors of post-recurrence survival in 457 breast cancer patients

Estrogens and antiestrogens stimulate release of bone resorbing activity by cultured human breast cancer cells.

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