Recurrent Benign Intracranial Hypertension (Pseudotumor Cerebri) During Pregnancy

Elian, Marta; Ben-Tovim, N.; Bechar, M; Bornstein, B

doi:10.1097/00006250-196805000-00015

Cited by 13 publications

(5 citation statements)

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“…Consistent with the literature, our patients primarily developed symptomatic IIH within the rst two trimesters [7,8]. Some authors previously assumed that pregnancy may provoke or exacerbate IIH [30][31][32]. But Giuse et al [33] and Digre et al [7] found no correlation between pregnancy and the diagnosis of IIH.…”

Section: Discussionsupporting

confidence: 85%

WITHDRAWN: Clinical course and ophthalmologic findings in idiopathic intracranial hypertension and pregnancy: a retrospective cohort study

Knoche

Danyel

Varlet

et al. 2023

Preprint

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Background: Idiopathic intracranial hypertension (IIH) has its highest prevalence among women of childbearing age. Therefore, it inevitably coincides with pregnancy. Because of physiological maternal changes during pregnancy and because of limited safety data on the available pharmaceuticals, concerns regarding a potential worsening of the disease during pregnancy arise. The literature background is limited to few retrospective studies. The aim of this study was to explore the impact of pregnancy on the visual outcome and on the management of pregnant women with IIH. Methods In this cohort study, IIH patients with documented pregnancies were retrospectively identified by medical database screening. The diagnosis of IIH was based on the revised Friedman criteria. Patient records were reviewed for IIH clinical features, treatment strategy and adherence to therapy. The visual acuity, visual field defects and the grade of papilledema at baseline and after pregnancy were compared. Complications over the course of pregnancy and during delivery were recorded. Results The database screening identified 16 IIH patients (26.8 ± 5.7 years, median = 27 years) with 19 documented pregnancies. The clinical presentation of IIH during pregnancy was similar to that of non-pregnant IIH patients with visual disturbances in 100% and headaches in 94.8% of patients. When comparing the overall visual acuity and the visual field mean deviation at baseline and at follow-up, no significant differences were found. The visual acuity at baseline in women who were diagnosed with IIH during pregnancy was significantly lower than in women who had been diagnosed with IIH prior to conception but improved at the time of follow-up. Papilledema grading improved after pregnancy. The adherence to therapy was low with 68.8% of patients discontinuing therapy. Conclusions Pregnancy did not lead to lasting visual impairment in our cohort of IIH patients, although many patients discontinued therapy during pregnancy. Further prospective studies are necessary to improve the medical care for IIH patients in pregnancy.

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Section: Discussionsupporting

confidence: 85%

WITHDRAWN: Clinical course and ophthalmologic findings in idiopathic intracranial hypertension and pregnancy: a retrospective cohort study

Knoche

Danyel

Varlet

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Consistent with the literature, our patients primarily developed symptomatic IIH within the first two trimesters [7,8]. It was previously assumed that pregnancy may provoke or exacerbate IIH [30][31][32]. Contrarily, Giuseffi et al [33], Digre et al [6] and a larger Swedish register study [34] with 902 IIH patients found no correlation between pregnancy and the diagnosis of IIH.…”

Section: Discussionsupporting

confidence: 88%

Clinical Course and Ophthalmologic Findings in Idiopathic Intracranial Hypertension and Pregnancy

Knoche,

Danyel,

Varlet

et al. 2023

Brain Sciences

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Idiopathic intracranial hypertension (IIH) has its highest prevalence among women of childbearing age and therefore frequently coincides with pregnancy. This retrospective cohort study aimed to explore the impact of pregnancy on the clinical course, ophthalmologic findings and on the therapeutic management of IIH patients. Individual patient records were reviewed for neuro-ophthalmologic findings, treatment strategy, adherence to therapy and pregnancy complications. Sixteen patients with 19 documented pregnancies were identified. The visual acuity, visual field defects and the grade of papilledema at baseline and after pregnancy were compared. The visual acuity and visual field mean deviation at baseline and at follow-up after pregnancy did not significantly differ. Papilledema at baseline was more pronounced in patients who had been diagnosed with IIH during pregnancy than in patients with established IIH. In this cohort, the visual acuity and the visual field were not lastingly impacted by pregnancy. The adherence to therapy was low, with 69% discontinuing treatment or medication.

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“…Beim sog. Pseudotumor cerebri -charakterisiert durch erhöhten intrakraniellen Druck, Kopfschrnerzen, Papillenodern, Sehstorungen,jedoch fehiende lokalisierte neurologische Symptornatik 61 Während einige Veroffentlichungen einen moglichen Zusammenhang zwischen Schwangerschaft und Pseudotumor cerebri beschreiben (12,56), wird von den meisten Autoren em EinfluB bzw. em haufigeres Auftreten dieser Erkrankung während der Schwangerschaft eher verneint (18,42,49).…”

Section: ) Pseudotumor Cerebriunclassified

“…Gesichtsfeiddefekte drohen, empfiehlt er, ebenso wie Erdheirn, Greer und Elian die vorzeitige Entbindnng bzw. den Abbruch der Schwangerschaft, was zur Besserung der Syrnptornatik fuhren soil (12,14,22,56). Poweii dagegen beschreibt den Pseudotumor cerebri ais gewohnlich selbstlimitierende Erkrankung mit sehr guter Prognose.…”

Section: ) Pseudotumor Cerebriunclassified

Geburtsleitung und Indikationen zur Interruptio und Sectio caesarea bei Augenerkrankungen - eine Übersicht

Kuba¹,

Kroll²

1997

Klin Monatsbl Augenheilkd

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Recurrent Benign Intracranial Hypertension (Pseudotumor Cerebri) During Pregnancy

Cited by 13 publications

References 0 publications

WITHDRAWN: Clinical course and ophthalmologic findings in idiopathic intracranial hypertension and pregnancy: a retrospective cohort study

WITHDRAWN: Clinical course and ophthalmologic findings in idiopathic intracranial hypertension and pregnancy: a retrospective cohort study

Clinical Course and Ophthalmologic Findings in Idiopathic Intracranial Hypertension and Pregnancy

Geburtsleitung und Indikationen zur Interruptio und Sectio caesarea bei Augenerkrankungen - eine Übersicht

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